Results 181 to 190 of about 26,964 (227)
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Hypolipidemic therapy for the metabolic syndrome
Pharmacological Research, 2006The metabolic syndrome appears to affect a significant proportion of the population and is associated with increased risk for development of cardiovascular disease as well as of type-2 diabetes. No single treatment for the metabolic syndrome as a whole yet exists.
CIGNARELLA, ANDREA +3 more
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Journal of Medicinal Chemistry, 1980
More than 110 derivatives of alkoxycinnamic acids were synthesized and their hypolipidemic activities were evaluated in a screening system with rats. Cinnamic acids, alpha-methylcinnamic acids, and their various esters with a higher p-alkoxy substituent were found to possess hypolipidemic activities higher than or comparable to that of clofibrate.
T, Watanabe +5 more
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More than 110 derivatives of alkoxycinnamic acids were synthesized and their hypolipidemic activities were evaluated in a screening system with rats. Cinnamic acids, alpha-methylcinnamic acids, and their various esters with a higher p-alkoxy substituent were found to possess hypolipidemic activities higher than or comparable to that of clofibrate.
T, Watanabe +5 more
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Hypolipidemic Drugs and Lipoprotein Metabolism
1972Insight into the mechanism of action and efficacy of hypolipidemic drugs has awaited the development of the current concepts of lipid transport (1). Fundamental is the fact that the blood fats-- cholesterol, phospholipid, and triglyceride-- do not circulate free in the plasma.
R I, Levy, T, Langer
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Mechanism of Action of Hypolipidemic Drugs
1975Drugs may decrease serum lipid levels by impairing lipid absorption, lipoprotein synthesis or release, or by stimulating lipid or lipoprotein catabolism (45). Recent data point out, however, that agents such as Clofibrate (CPIB), generally thought to act only by inhibiting lipid and lipoprotein synthesis and release (3), may also affect lipid ...
C R, Sirtori +2 more
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Synthesis of Potential Hypolipidemic Agents
Journal of Pharmaceutical Sciences, 1969Derivatives of 2-(p-chlorophenoxy)-2-methylpropionic acid (I) and 2-(p-chlorophenylthio)-2-methylpropionic acid (II) have been synthesized for the purpose of studying their potential hypolipidemic activity.
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Presse medicale (Paris, France : 1983), 1987
All types of hyperlipoproteinaemia must be corrected to prevent or delay the atheroma they produce, or even bring about its regression. A dietetic regimen is prescribed first to be completed, if necessary, by a medicinal treatment. Once instituted, these treatments must be pursued indefinitely, the return to normal lipid levels being a sign of their ...
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All types of hyperlipoproteinaemia must be corrected to prevent or delay the atheroma they produce, or even bring about its regression. A dietetic regimen is prescribed first to be completed, if necessary, by a medicinal treatment. Once instituted, these treatments must be pursued indefinitely, the return to normal lipid levels being a sign of their ...
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HYPOLIPIDEMIC DRUGS AND HYPERLIPOPROTEINEMIA
Annals of the New York Academy of Sciences, 1971R I, Levy, T, Langer
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[Aryloxy- and arylthioalkylamine hypolipidemic agents].
Il Farmaco; edizione scientifica, 1983Aryloxy and arylthioalkylamines related respectively to clofibrate and 2-(3,5-di-t-butyl-4-hydroxyphenylthio)hexanoic acid, a derivative of an active probucol metabolite, were prepared and pharmacologically screened as hypolipidemic substances. Some of them showed interesting antilipemic activity but also, unfortunately, high acute toxicity.
DURANTI E +5 more
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Hypolipidemic alkoxybenzoic acids
Journal of Medicinal Chemistry, 1976V G, DeVries +3 more
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