Results 91 to 100 of about 11,363 (224)

The effects of hypolipidemic agents derived from procetofenic acid on the activity of superoxide dismutase and glutathione peroxidase and on malonyl dialdehyde production of rat liver

, 1984
Male and female rats were treated with hypolipidemic agents derived from procetofenic acid, namely fenofibrate ( procetofene ), cholestyrammonium alpha-(4-p-chlorobenzoyl-phenoxy)-isobutyrate (Alfa-1081) and alpha-(4-p-chlorobenzoyl-phenoxy)-isobutyryl ...
Borzatta V, Rotilio G, Barbanti M., Rossi L, Ciriolo MR, Cristofori M, MAVELLI, Irene   +6 more
core  

New compounds with a dihydropyridine framework as promising hypolipidemic and hepatoprotective agents

Research Results in Pharmacology
Introduction: To solve the problem of complex and safe pharmacological correction of metabolic disorders, including hyperlipidemia, hyperglycemia, and liver lesions is currently very important. With this in mind, the new derivatives of cyanothioacetamide
Elena S. Ketova, Anna V. Myazina, Elena Yu. Bibik, Sergey G. Krivokolysko   +3 more
doaj   +1 more source

Liensinine Ameliorating Oxidative Damage to Vascular Endothelium In Vitro via Upregulating eNOS and Nrf2/HO‐1 Signaling

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
The present studies of network pharmacology, molecular docking and molecular dynamics simulation indicated that liensinine might ameliorate oxidative damage to vascular endothelium (ODVE) by regulating the targets of Nrf2, which is encoded by the NFE2L2 gene. Then the in vitro study further showed that liensinine exhibited an obvious protection against
Feng Gao, Fengjiao Deng, Qiaowei Du, Tianya Xia, Yayi Deng, Shuang Liu, Bin Yu, Chenxiao Shan   +7 more
wiley   +1 more source

Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121)

, 2011
YS-121 [2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid] is the result of target-oriented structural derivatization of pirinixic acid.
Gabler, Matthias, Matthias Gabler, Schubert-Zsilavecz, Manfred, Manfred Schubert-Zsilavecz   +3 more
core   +1 more source

Association Between Estimated Glucose Disposal Rate and Biological Aging Among U.S. Adults: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Biomarkers of biological aging, including homeostatic dysregulation (HD), Klemera–Doubal method biological age (KDM‐BA), and phenotypic age (PA), provide multidimensional quantification of the aging process. Although insulin resistance correlates with accelerated aging, the connection between biological aging and the ...
Mengjie Zhao, Jing Cao, Mengxuan Li, Jiwei Zhang, Wantong Zhang, Qiuyan Li   +5 more
wiley   +1 more source

C4 Functionalization of the Isoquinoline Core via Oxidative Radical Substitution

ChemistrySelect, Volume 11, Issue 21, 4 June 2026.
The isoquinoline ring can be easily functionalized at C‐4 through a radical‐oxidative substitution process. The resulting products can be readily cyclized under basic conditions, facilitating the construction of pyranones fused to the isoquinoline scaffold. ABSTRACTIn this work, we report a straightforward synthetic procedure that enables the selective
Oscar Coral, Cesar A. Mujica‐Martinez, Alfredo Vázquez   +2 more
wiley   +1 more source

Novel euglycemic and hypolipidemic agents: Pyridine containing unsaturated thiazolidinediones

, 1999
403-406Pyridyl containing 2,4-thiazolidinediones having cyclic amine as linker have been synthesized. Both unsaturated thiazolidinedione 6 and saturated thiazolidinedione 5 and their various salts have been evaluated in db/db mice for euglycemic ...
Bhushan, Vidya, Rao, P Bheema, Reddy, K Anantha, Reddy, N Jaipal, Reddy, A Sekar, Rajagopalan, R, Lohray, B B, Vikramadithyan, Reeba K   +7 more
core  

Are We Using Ezetimibe As Much As We Should?

Biomarker Insights
Lipid-lowering therapies, particularly non-statin regimens, are underutilized as ~2/3 of patients with atherosclerotic cardiovascular (CV) disease (CVD) are not optimally managed, and do not attain target low-density lipoprotein cholesterol (LDL-C ...
Antonis A Manolis, Theodora A Manolis, Dimitri P Mikhailidis, Antonis S Manolis   +3 more
doaj   +1 more source

Systemic retinoids for treatment of recalcitrant IgA pemphigus

Orphanet Journal of Rare Diseases, 2018
IgA pemphigus is an exceedingly rare autoimmune blistering disorder, caused by IgA autoantibodies against desmosomal proteins. No treatment option has been found to be universally effective.
Franziska Schauer, Johannes Steffen Kern, Dimitra Kiritsi   +2 more
doaj   +1 more source

Hydroxytyrosol nicotinate, a new multifunctional hypolipidemic and hypoglycemic agent

Biomedicine & Pharmacotherapy, 2018
Hydroxytyrosol (HT) is a natural polyphenol antioxidant that exists in olive oil. In the study of multifunctional hypolipidemic of nicotinic derivatives, we found that hydroxytyrosol nicotinate (HT-N) incorporation of niacin with HT displayed ?-glucosidase inhibitory activities in vitro, such as yeast ?-glucosidase (IC50?=?117.72??M) and rat intestinal
Yun-Dong, Xie, Zi-Zhang, Chen, Na, Li, Wen-Fang, Lu, Yan-Hong, Xu, Yuan-Yuan, Lin, Li-Hua, Shao, Qiu-Tang, Wang, Li-Ying, Guo, Yu-Qiong, Gao, Guang-De, Yang, Yi-Ping, Li, Xiao-Li, Bian   +12 more
openaire   +2 more sources