Results 171 to 180 of about 10,287 (203)

Lentysine: A new hypolipidemic agent from a mushroom

Life Sciences, 1970
Abstract The actions of lentysine on the serum and liver lipids in rats have been investigated. Lentysine markedly reduced serum cholesterol, phospholipids and triglycerides, both in intact rats and in animals fed a high fat diet. However, this substance showed no effect on liver lipid levels.
A. Tensho, T. Takenawa, Y. Tsukitani, H. Kikuchi, Kohki Yoshida, T. Rokujo, T. Kamiya   +6 more
openaire   +3 more sources

Metabolic Effects of a New Hypolipidemic Agent, Ciprofibrate

Journal of Pharmaceutical Sciences, 1979
Ciprofibrate, a new orally effective hypolipidemic agent like clofibrate, suppressed tyloxapol-induced hypercholesterolemia in rats. Ciprofibrate at 10 mg/kg was effective. Clofibrate required a dosage of 180 mg/kg to suppress the tyloxapol effect. Norepinephrine-induced free fatty acid release was inhibited by clofibrate in rats in accordance with ...
A. L. Beyler, Aaron Arnold, John P. McAuliff   +2 more
openaire   +3 more sources

Studies of hypolipidemic agents. 1. Synthesis and hypolipidemic activities of alkoxycinnamic acid derivatives

Journal of Medicinal Chemistry, 1980
AbstractAlkoxyzimtsäurederivate der Strukturen (I) bis (VIII) werden dargestellt und an Ratten auf hypolipidämische Wirkung untersucht.
K. Hayashi, T. Watanabe, S. Yoshimatsu, S. Takeyama, K. Sakai, K. Takashima   +5 more
openaire   +4 more sources

Hypolipidemic Agents

2006
Publisher Summary Drugs that lower the concentration of lipoproteins in the plasma by inhibiting their production in the organism or by removing them from the plasma are called hypolipidemic or antisclerotic drugs. Atherosclerosis is a condition of the organism characterized by elevated levels of atherogenic lipoproteins in blood plasma, lipid ...
V.J. Hruby, R.S. Vardanyan
openaire   +2 more sources

Synthesis of Potential Hypolipidemic Agents

Journal of Pharmaceutical Sciences, 1969
Derivatives of 2-(p-chlorophenoxy)-2-methylpropionic acid (I) and 2-(p-chlorophenylthio)-2-methylpropionic acid (II) have been synthesized for the purpose of studying their potential hypolipidemic activity.
openaire   +3 more sources

Biological Activity of the Hypolipidemic Agent, N2-n-Butylindazolone

Journal of Pharmaceutical Sciences, 1984
Previously, a series of N-substituted indazolone derivatives proved to be effective hypolipidemic agents in rodents. The most effective agent, N2-n-butylindazolone, at 20 mg/kg/d was shown to suppress the levels of cytoplasm acetyl coenzyme A required for cholesterol and fatty acid synthesis as well as sn-glycerol-3-phosphate acyl transferase and ...
Steven D. Wyrick, Iris H. Hall, P. J. Voorstad, W.L. Williams   +3 more
openaire   +3 more sources

Syntheses and Biological Evaluation of Alkanediamines as Antioxidant and Hypolipidemic Agents

Bioorganic & Medicinal Chemistry, 2001
A new series of compounds belonging to N,N'- [bis (1-aryl-6-hydroxy-hex-2-ene-1-one-3-yl)-1,n-alkanediamines (2-5a-f) have been synthesized and evaluated for antioxidant and hypolipidemic activities. Amongst all the synthesized compounds, seven compounds namely 2c, 2e, 4c, 5b, 5c, 5e and 5f exhibit potent antioxidant activity. These compounds have also
Raja Roy, Ramesh Chander, Amiya P. Bhaduri, Bhawani S. Joshi, Ashok Kumar Khanna, Sanjay Batra   +5 more
openaire   +3 more sources

Comparative study of several hypolipidemic agents related to clofibrate

Atherosclerosis, 1974
Abstract Clofibrate and 3 related drugs (13.437 SU, GP 45.699 and MK 185) have been tested in man with the same protocol and by the same medical team. Comparison of the results of these clinical trials shows that the 4 drugs have common effects with regard to lipidemia, but differ in their action on uricemia and tolerance to antivitamin K: All of ...
V. Beaumont, Buxtorf Jc, Bernard Jacotot, Beaumont Jl   +3 more
openaire   +3 more sources

Hypolipidemic agents alter hepatic mitochondrial respiration in vitro

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1995
The direct effects of three different classes of structurally diverse hypolipidemic agents on respiration were studied in mitochondria isolated from donor Sprague-Dawley rats. Two classes of peroxisome proliferators (i.e. plasticizers and hypolipidemic hormones and drugs) and one class of peroxisome inhibitors (i.e.
David S. Chance, Michael McIntosh
openaire   +3 more sources

[Aryloxy- and arylthioalkylamine hypolipidemic agents].

Il Farmaco; edizione scientifica, 1983
Aryloxy and arylthioalkylamines related respectively to clofibrate and 2-(3,5-di-t-butyl-4-hydroxyphenylthio)hexanoic acid, a derivative of an active probucol metabolite, were prepared and pharmacologically screened as hypolipidemic substances. Some of them showed interesting antilipemic activity but also, unfortunately, high acute toxicity.
DURANTI E, BONIFAZI, PAOLA, SALVATORI A, BALSAMINI, CESARINO, PERUZZI G, CANTONI, ORAZIO   +5 more
openaire   +2 more sources