Results 21 to 30 of about 19,505 (219)

Study of prescribing patterns of hypolipidemic agents in a tertiary care teaching hospital in North India

National Journal of Physiology, Pharmacy and Pharmacology, 2017
Background: Lipid-lowering agents are now the cornerstone of treatment used to reduce the risk of coronary events. Since there is wide variation in selection and use of these drugs, drug utilization studies help to evaluate and analyze drug therapy from ...
Seema Gupta, Rajesh Kumar, Dharminder Kumar, Sanjeev Bhat, Dinesh Kumar, Nusrat Kareem Bhat, Surbhi Mahajan   +6 more
doaj   +1 more source

Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3-b] Pyrrole Derivatives

Molecules, 2022
Novel pyrrolo [2,3-b] pyrrole derivatives were synthesized and their hypolipidemic activity was assessed in hyperlipidemic rats. The chemical structures of the new derivatives were confirmed through spectral analysis.
Moumen S. Kamel, Amany Belal, Moustafa O. Aboelez, E. Kh. Shokr, H. Abdel-Ghany, Hany S. Mansour, Ahmed M. Shawky, Mahmoud Abd El Aleem Ali Ali El-Remaily   +7 more
doaj   +1 more source

A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials [PDF]

, 2017
There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease.
Agresti, C., Buscarinu, Maria Chiara, Calo', Giorgia, Eleuteri, Cecilia, Ferrari, F., Mechelli, Rosella, Olla, S., Ristori, Giovanni, Romano, Silvia, Salvetti, Marco, Umeton, Renato, Veroni, Chiara   +11 more
core   +2 more sources

The Use of Primary Care Electronic Health Records for Research: Lipid Medications and Mortality in Elderly Patients

Pharmacy, 2019
General practice electronic health record (EHR) data have significant potential for clinical research. This study demonstrates the feasibility of utilising longitudinal EHR data analysis to address clinically relevant outcomes and uses the relationship ...
Adam J. Hodgkins, Judy Mullan, Darren J. Mayne, Andrew Bonney   +3 more
doaj   +1 more source

Medicinal plants with cholesterol-lowering effect marketed in the Buenos Aires-La Plata conurbation, Argentina : An Urban Ethnobotany study [PDF]

, 2015
Fil: Hurrell, Julio Alberto. Laboratorio de Etnobotánica y Botánica Aplicada (LEBA). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Puentes, Jeremías P..
Arenas, Patricia Marta, Hurrell, Julio Alberto, Puentes, Jeremías P.   +2 more
core   +2 more sources

Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus [PDF]

, 2014
In hepatitis C virus infection, replication of the viral genome and virion assembly are linked to cellular metabolic processes. In particular, lipid droplets, which store principally triacylglycerides (TAGs) and cholesterol esters (CEs), have been ...
Hague, Charlotte V., Liefhebber, Jolanda M.P., McLauchlan, John, Wakelam, Michael J.O., Zhang, Qifeng   +4 more
core   +1 more source

Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes [PDF]

, 2006
Background: PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host ...
C Hubeau, RB Moss, P Reineck, AA Ionescu, LS Nixon, ME Poynter, P Delerive, SW Chung, BM Forman, W Wahli, JD Tugwood, JM Shipley, A Madej, JP Despres, N Marx, B Staels, Z Israelian-Konaraki, A Trifilieff, MA Birrell, M Roulet, PM Farrell, AP Sampson, JT Zakrzewski, J Carlstedt-Duke, SD Freedman, SM Loitsch, KA Kreuzer, JL Su, JD Dignam, TP Dean, K Balough, TZ Khan, A Augarten, F Akbiyik, I Inoue, DC Jones, P Greally, E Dagli, TA Waldmann, JH Parmentier, K Beier, C Andersson, M Ollero, H Pall, G Chinetti, PR Devchand, N Marx, AE Lovett-Racke, A Linden, F McAllister, RB Moss, RB Moss, C Hubeau, RU Sorensen   +53 more
core   +1 more source

The ansamycins: hypolipidemic agents stimulating cholesterol removal by nonclassical mechanisms.

Journal of Lipid Research, 1994
The ansamycins CGP 43371 and CGS 24565 are derivatives of the antibiotic rifamycin that reduce plasma cholesterol levels in both primate and nonprimate species.
J C Gibson, W H Lee, J R Piccolo
doaj   +1 more source

Chemical Genetics of Acetyl-CoA Carboxylases [PDF]

, 2013
Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for ...
Deliang Cao, Dixian Luo, Gebo Wen, Jianghua Liu, Jing Zhong, Jingjing Tan, Qinghai Zhang, Renxian Cao, Xuyu Zu, Ying Wu   +9 more
core   +2 more sources

MODELING OF MICE AS TEST ANIMALS FOR A PRECLINICAL STUDY OF HYPOLIPIDEMIC AGENTS

Jurnal Farmasi Sains dan Praktis, 2023
Animal models suitable for preclinical research are necessary for the discovery of hypolipidemic agents. Various publications have presented alternative dyslipidemia animal models, but identifying a feasible and stable method would serve as a solid ...
Setiyo Budi Santoso, Widarika Santi Hapsari, Renny Setyowati   +2 more
doaj   +1 more source