Results 61 to 70 of about 10,875 (185)

Amino acid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemic agents: synthesis and biological evaluation. [PDF]

RSC Adv, 2021
Zhang X, Liu DY, Shang H, Jia Y, Xu XD, Tian Y, Guo P.   +6 more
europepmc   +1 more source

Investigating the Antidiabetic Effects of Calotropis procera: Preclinical Assessment

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Calotropis Procera In vitro/Diabetic rodent model Improved β‐cell function, reduced hepatic gluconeogenesis antioxidant activity. ABSTRACT Diabetes mellitus (DM) is a metabolic disease characterized by persistent hyperglycemia, oxidative stress, and inflammation, often leading to severe complications.
Yu‐Cheng Kuo, Musa I. Ajibola, Halimat Y. Lukman, Bashir Lawal, Lung‐Ching Chen, Sheng‐Liang Huang, Olawale David Ajayi, Sunday Amos Onikanni, Saheed Sabiu, Leandro Miranda‐Alves, Hsu‐Shan Huang   +10 more
wiley   +1 more source

Synergistic Anti‐Obesity Effect of Akkermansia muciniphila AKM Lab‐01 and Garcinia cambogia Extract via Gut Microbiota Remodeling in Diet‐Induced Obese Mice

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Combined administration of pasteurized Akkermansia muciniphila (AKM Lab‐01) and Garcinia cambogia extract (GCE) alleviates high‐fat‐diet‐induced obesity in mice by reducing adiposity, metabolic disturbances, and adipose inflammation, while remodeling gut microbiota and adipose transcriptome, revealing a gut‐host metabolic axis that underpins the ...
Baojia Huang, Zhipeng Chen, Wenbin Xue, Zilun Pu, Yalin Zhou, Sherlyn Sze Ning Koay, Ping Kong, Yingying Zhao, Lihong Tai, Zhou Lan, Yibo Xian, Amanda Juan Chen   +11 more
wiley   +1 more source

A Proof-of-Concept for a Hypolipidemic Brown Trout Model

Toxics
The impacts of hypolipidemic pharmaceuticals on fish lipid metabolism remain unexplored. However, data points to similar effects and mechanisms of action between fish and humans.
Tiago Lourenço, Eduardo Rocha, José Fernando Gonçalves, Maria João Rocha, Tânia Vieira Madureira   +4 more
doaj   +1 more source

Lipid-Lowering Effects of Ethyl 2-Phenacyl-3-aryl-1H-pyrrole- 4-carboxylates in Rodents

Molecules, 2004
A series of substituted 2-phenacyl-3-phenyl-1H-pyrrole-4-carboxylates were prepared from substituted acetophenones in 6 steps. The final condensations between a chloroenal and an aminoketone were carried out under neutral conditions in parallel to yield ...
Bruce S. Burnham, John T. Gupton, Keith Krumpe, John R. Lukens, Robert B. Miller, Joshua D. Berkowitz, Bryan J. McCranor, Kam Suet Lam, Josephine Glersaye, Ulander Miott, Brett M. Taylor, Donna L. Wilson, Shahzad Rifat, Gerard A. Dalglish, Daniel C. Smith, Michael A. Evans, Anthony Argenti, Adam Getzel, Kathy O'Toole-Colin, Justin M. Holub   +19 more
doaj   +1 more source

Reconceptualizing Dyslipidemia: Diversity of Lipid Imbalances and Their Clinical Implications; A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims The traditional definition of dyslipidemia focuses on isolated lipid changes (LDL‐C, HDL‐C, triglycerides) and may not fully capture the biological complexity or clinical variability of lipid imbalances. Recent evidence challenges this narrow view, suggesting that dyslipidemia involves broader disruptions in lipid ...
Ali Mansoursamaei, Amirhossein Yadegar, Fatemeh Mohammadi, Seyed Arsalan Seyedi, Soghra Rabizadeh, Sahar Karimpour Reyhan, Alireza Esteghamati, Manouchehr Nakhjavani   +7 more
wiley   +1 more source

Barbaloin Attenuates Cisplatin‐Induced Hippocampal Neurotoxicity by Suppressing Oxidative Stress, Neuroinflammation, and Apoptosis: In Vivo and In Silico Evidence

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Important Aloe vera phytonutrient, barbaloin, inhibits the neurotoxic effects of cisplatin on hippocampus, which involves reducing oxidative stress, neuroinflammation, and apoptosis, thereby restoring the balance of neurotransmitters and cognition. The generated docking structures with 100‐ns molecular dynamics simulations show stable energy‐minimized ...
Rahamat Unissa Syed, Rihab Akasha, Nancy Mohammad Elafandy, Sally Hassan Abobaker, Afrah Nashmi Al‐Shammari, Lama Abdullah Altwalah, Rawabi Mohammed Menwer Aldafeeri, Amira Ibrahim Mohammed Ahmed Alfaki, Mohd Sajjad Ahmad Khan, Ashgan A. Ahmed   +9 more
wiley   +1 more source

Pharmacological investigation of bezafibrate, a hypolipidemic agent. (2). Mechanism of the hypolipidemic action of bezafibrate in rats.

Folia Pharmacologica Japonica, 1988
The mechanism of the hypolipidemic action of bezafibrate was investigated in rats. Bezafibrate decreased the incorporation of 14C-acetic acid into the liver and serum triglyceride and inhibited liver acetyl CoA carboxylate activity. Bezafibrate increased liver beta-oxidation, but it had no effect on lipolysis and triglyceride secretion from the liver ...
KUSAMA, Hiroshi, NISHIYAMA, Masahiko, MATSUBARA, Yasuhito, IKEDA, Shigeru   +3 more
openaire   +3 more sources

Six‐ and Twelve‐Month Changes in Body Composition and 24‐h Energy Expenditure After a Very Low‐Calorie Ketogenic Diet

Obesity, Volume 34, Issue 8, Page 1558-1568, August 2026.
ABSTRACT Objective This study assessed changes in body composition and 24‐h energy metabolism at 6 and 12 months after initiation of a 1‐month very low‐calorie ketogenic diet (VLCKD) in women with obesity. Methods Seventeen women with obesity who completed a 1‐month VLCKD underwent a 4‐week transition phase with carbohydrate reintroduction, followed by
Alessio Basolo, Paolo Piaggi, Valentina Angeli, Paola Fierabracci, Chiara Bologna, Giordano Paolucci, Guido Salvetti, Luca Chiovato, Jonathan Krakoff, Alberto Landi, Ferruccio Santini   +10 more
wiley   +1 more source

Apiotrichum‐Centered Fungal Interaction Network Disturbance Correlates With Increased Arterial Stiffness

Aging Cell, Volume 25, Issue 8, August 2026.
Apiotrichum‐centered gut fungal network disturbance correlates with increased arterial stiffness. Five driver genera including Apiotrichum, Mycothermus, Flavocillium, Hyaloscypha, and Microscypha regulate the interaction shift. Thirty‐nine metabolites comprising organic acids, fatty acyls, and sucrose target vasoconstriction regulators CYP11B2, ROCK2 ...
Jiarui Chen, Jialin He, Bingqi Ye, Jialu Yang, Ludi Liu, Jingmeng Ju, Sinan Li, Benjie Li, Min Xia, Yan Liu   +9 more
wiley   +1 more source