Results 121 to 130 of about 3,679,356 (272)

Epigenetic analyses suggest different pathways during pregnancy for development of Type 1 diabetes in children with high versus low‐neutral human leukocyte antigen‐risk

Journal of Internal Medicine, EarlyView.
Abstract Background and objective The development of Type 1 diabetes (T1D) is shaped by genetic predisposition and epigenetic regulation. Human leukocyte antigen (HLA) risk alleles are major genetic determinants, but the epigenetic landscape in relation to disease onset remains unclear.
Shamila D. Alipoor, Angelica Ahrens, Julia Åkesson, Thomas Hillerton, Mika Gustafsson, Maria Lerm, Johnny Ludvigsson   +6 more
wiley   +1 more source

The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells [PDF]

, 2015
The USFDA approved "epigenetic drug", Decitabine, exerts its effect by hypomethylating DNA, demonstrating the pivotal role aberrant genome-wide DNA methylation patterns play in cancer ontology.
AF Cashen, AP McGovern, AT Fathi, B Chowdhury, C Plass, C Stresemann, CG Spruijt, DP Genereux, E Jabbour, E Pronier, G Ficz, GA Otterson, H Zhang, JA Plumb, JK Christman, JR Graff, K Ghoshal, K Moran-Crusio, K Patel, K Schneider, KD Robertson, L Schermelleh, LB Sontag, M Oka, M Tahiliani, M-L Chen, ME Figueroa, MM Suzuki, MW Kellinger, NJ Farinha, PA Jones, PA Jones, RL Momparler, S Ito, S Kriaucionis, S Mizuno, S Oz, SA Kim, SB Baylin, SJ Collins, SJ Collins, SMC Langemeijer, W Blum, Y Cui   +43 more
core   +1 more source

Epigenetic Regulation in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch, Arne Sönke Schäfer, Denica Kuzmanova, Dominique S. Michaud   +3 more
wiley   +1 more source

A phase 1 clinical trial of vorinostat in combination with decitabine in patients with acute myeloid leukaemia or myelodysplastic syndrome [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108599/1/bjh13016 ...
Bredeson, Christopher, Eid, Joseph E., Frankel, Paul, Gojo, Ivana, Goldberg, Stuart L., Issa, Jean‐pierre, Kirschbaum, Mark, Kujawski, Lisa A., Lubiniecki, Gregory M., Marks, Peter, Sun, Xing, Tosolini, Alessandra, Yang, Allen   +12 more
core   +1 more source

A stage‐dependent seed defense response to explain efficient seed transmission of Xanthomonas citri pv. fuscans to common bean

Plant, Cell &Environment, EarlyView.
Abstract Although seed represents an important means of plant pathogen dispersion, the seed–pathogen dialogue remains largely unexplored. A multiomic approach was performed at different seed developmental stages of common bean (Phaseolus vulgaris L.) during asymptomatic colonization by Xanthomonas citri pv.
Armelle Darrasse, Łukasz Paweł Tarkowski, Martial Briand, David Lalanne, Nicolas W. G. Chen, Matthieu Barret, Jerome Verdier   +6 more
wiley   +1 more source

The blind men and the AML elephant:can we feel the progress? [PDF]

, 2016
The pharmacological therapy of non-promyelocytic acute myeloid leukemia (AML) has remained unchanged for over 40 years with an anthracycline–cytarabine combination forming the backbone of induction treatments.
A Wanquet, AK Burnett, AK Burnett, AK Burnett, AK Burnett, AK Burnett, AK Burnett, AM Perry, D Garfield, DW Milligan, EL Korn, Experts in Chronic Myeloid Leukemia, F Ravandi, F Ravandi, F Turturro, H Dombret, HF Fernandez, I Gojo, J Loke, K Wheatley, K Wheatley, LR Silverman, M Lübbert, M Weil, MR Luskin, MW Drummond, NI Cherny, P Fenaux, P Greenberg, P Paschka, PB Bach, PF Bross, RC Young, RK Hills, S Amadori, S Castaigne, SH Petersdorf, SY Zafar, ZY Wang   +38 more
core   +3 more sources

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Chromatin remodeling agents for cancer therapy [PDF]

, 2008
Alterations in chromatin structure profoundly influence gene expression during normal cellular homeostasis and malignant transformation. Methylation of cytosines within CpG islands located in promoter and proximal coding regions facilitates recruitment ...
Cinti, Caterina, Estenoz, Mariela, Giordano, Roberto, La Sala, Dario, Magnano, Anna   +4 more
core   +1 more source

Integrating polygenic and methylation risk scores for pleural mesothelioma risk stratification

International Journal of Cancer, Volume 158, Issue 11, Page 2866-2879, 1 June 2026.
What's new? Asbestos exposure is a major risk factor for pleural mesothelioma (PM). Most asbestos‐exposed individuals do not develop PM, suggesting that it arises from a complex interplay between environmental and genetic factors. This study examined the utility of polygenic risk scores (PRS) and methylation risk scores (MRS) in incorporating genetic ...
Khadija Sana Hafeez, Carla Debernardi, Alessandra Allione, Elton Jalis Herman, Simonetta Guarrera, Daniela Ferrante, Anna Aspesi, Marika Sculco, Marta La Vecchia, Carlotta Sacerdote, Federica Grosso, Christina M. Lill, Giovanna Masala, Marcela Guevara, Matthias B. Schulze, Salvatore Panico, Yaszan Asgari, Seehyun Park, Giovanna Tagliabue, Anne Tjønneland, Antonio Agudo, Elisabete Weiderpass, Corrado Magnani, Irma Dianzani, Paolo Vineis, Elisabetta Casalone, Giuseppe Matullo   +26 more
wiley   +1 more source

A case of atypical prolonged hematologic toxicity with azacitidine in Chronic Myelomonocytic Leukemia (CMML), review of literature and a proposal of management

Mediterranean Journal of Hematology and Infectious Diseases, 2012
Hypomethylating drugs are useful and approved in the management of myelodysplastic syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML). However, phase 2 and 3 studies that assessed these agents in MDS, have included only a small number of CMML ...
Elena Elli, Caterina Cecchetti, Angelo Belotti, Lorenza Borin, Enrico Maria Pogliani   +4 more
doaj   +3 more sources