Results 1 to 10 of about 6,181 (105)

Systemic anti-cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy. [PDF]

Int J Cancer
What's new? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Higgins C, Gauthier LR, Smith BH, Colvin L.   +3 more
europepmc   +2 more sources

Novel Active Homo-Aza (Lactam) Steroidal Antimetabolites for the Treatment of Human Pancreatic and Colorectal Cancer [PDF]

Pharmaceuticals
Background: Colorectal and pancreatic cancers remain therapeutically challenging, with limitations in efficacy and limitations due to toxicity from conventional antimetabolites such as 5-fluorouracil (5-FU), methotrexate (MTX), and gemcitabine (GEM ...
Konstantinos E. Alifieris, Panagiotis Dalezis, Sofia Sagredou, Ioanna A. Anastasiou, Maria Deligiorgi, Christos Siokatas, Nikolaos Spanakis, Konstantinos Almpanakis, Maria Voura, Kyriakos Orfanakos, Mihalis Panayiotidis, Vasiliki Sarli, Dimitrios T. Trafalis   +12 more
doaj   +2 more sources

Subsequent pregnancies after a diagnosis of pregnancy-associated cancer. [PDF]

Acta Obstet Gynecol Scand
Approximately 1 in 15 women diagnosed with pregnancy‐associated cancer went on to have a subsequent pregnancy, with markedly higher probabilities in those diagnosed before the age of 35 and those who did not undergo antineoplastic treatments. Abstract Introduction Pregnancy‐associated cancer is a rare but clinically significant event.
Esposito G, Peccatori FA, Franchi M, Trojano G, Corrao G, La Vecchia C, Parazzini F, Cantarutti A.   +7 more
europepmc   +2 more sources

Trends in antineoplastic drug use, cost and prescribing patterns among patients with lung cancer in nine major cities of China, 2016–2020: a retrospective observational study based on inpatient and outpatient hospital data

BMJ Open, 2023
Objectives It is unclear whether the use of antineoplastic drugs for patients with lung cancer in China has changed after the implementation of the national drug price negotiation in 2016 and continual update of clinical guidelines.
Yi Liu, Lixin Zhou, Xiaohong Zhang, Feng Yang, Rongrong Fan, Jingyuan Shang, Lin Huang, Yanguo Liu, Chunyan Zhang, Li'an Zu, Yufei Feng   +10 more
doaj   +1 more source

Antineoplastics Encapsulated in Nanostructured Lipid Carriers

Molecules, 2021
Ideally, antineoplastic treatment aims to selectively eradicate cancer cells without causing systemic toxicity. A great number of antineoplastic agents (AAs) are available nowadays, with well-defined therapeutic protocols.
Gustavo Henrique Rodrigues da Silva, Ludmilla David de Moura, Fabíola Vieira de Carvalho, Gabriela Geronimo, Talita Cesarim Mendonça, Fernando Freitas de Lima, Eneida de Paula   +6 more
doaj   +1 more source

Polimorfismos genéticos asociados a toxicidad en el tratamiento con 5-fluorouracilo en pacientes con cáncer colorrectal

Oncología, 2022
Introduction: Colorectal cancer is the most common malignancy of the digestive tract. The treatment is based basically on administering antitumor medications, like 5-fluorouracil (5-FU), which belongs to the antimetabolites, antineoplastic agents ...
Cristina Benavides Tutillo, Gabriela Molina Pinos , Maritza Ochoa Castro   +2 more
doaj   +1 more source

The Role of Chemotherapy in the Treatment of Hodgkin’s Disease

Revista Brasileira de Cancerologia, 2023
Trabalho apresentado no Simpósio Internacional sobre Doença de Hodgkin, realizado no Instituto Nacional de Câncer no Rio de Janeiro — 16 a 20 de Janeiro de 1967. Transcrição da gravação, revisto o original pelo autor.
David A. Karnofsky
doaj   +1 more source

Xeloda as first-line therapy of metastatic colorectal cancer-our experience [PDF]

Archive of Oncology, 2002
BACKGROUND: Results of phase III clinical studies comparing efficacy of Xeloda vs. standard 5-FU/FA protocols as first line therapy of metastatic colorectal carcinoma (MCRC), have shown better efficacy of Xeloda, with less toxic adverse effects, apart ...
Kovčin Vladimir, Ješić Rada, Krivokapić Zoran V., Andrić Zoran, Pavlović Aleksandra   +4 more
doaj   +1 more source

Study of the use possibility of the chemical-biological adduct of the 1,1-bis-[5-bromopyrimidine-2’,4’-diono-1’-il]-2-bromo-2’-chloroethylene and bacterial lectin for the treatment of the Pliss’ lymphosarcoma

Zaporožskij Medicinskij Žurnal, 2015
Aim. Study of the pyrimidine metabolism antimetabolites that can be preformed compounds in the link of biosynthetic processes and can brake tumour’s growth is a more successful, perspective finding direction of new antitumor medications.
O. V. Welchinska
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source