Results 31 to 40 of about 14,917 (240)
Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]
, 2017 Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana +5 more
core +1 more source
Oncogenic Roles and Inhibitors of DNMT1, DNMT3A, and DNMT3B in Acute Myeloid Leukaemia
Biomarker Insights, 2019 Epigenetic alteration has been proposed to give rise to numerous classic hallmarks of cancer. Impaired DNA methylation plays a central role in the onset and progression of several types of malignancies, and DNA methylation is mediated by DNA ...
Kah Keng Wong +2 more
doaj +1 more source
Haematologica, 2010 Hypomethylating agents have recently been shown to improve the outcome of patients with myelodysplastic syndrome. A meta-analysis and systematic review was carried out of randomized controlled trials comparing treatment with hypomethylating agents to ...
Ronit Gurion +6 more
doaj +1 more source
A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers [PDF]
, 2016 The azanucleosides azacitidine and decitabine are currently used for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) in patients not only eligible for intensive chemotherapy but are also being explored in other ...
Buschbeck, Marcus +5 more
core +2 more sources
Novel therapeutic strategies: hypomethylating agents and beyond [PDF]
Hematology, 2012 Abstract The treatment of symptomatic and high-risk myelodysplastic syndrome (MDS) spans several therapeutic goals and options. Key to the successful therapy of these heterogeneous diseases is careful characterization and diagnosis, including clinical, cytogenetic, biological, and molecular evaluation of individual patients.
openaire +2 more sources
Clinical Results of Hypomethylating Agents in AML Treatment [PDF]
Journal of Clinical Medicine, 2014 Epigenetic changes play an important role in the development of acute myeloid leukemia (AML). Unlike gene mutations, epigenetic changes are potentially reversible, which makes them attractive for therapeutic intervention. Agents that affect epigenetics are the DNA methyltransferase inhibitors, azacitidine and decitabine.
Cruijsen, Marjan +3 more
openaire +3 more sources
The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer [PDF]
, 2014 PURPOSE: To investigate SGI-110 as a "chemosensitizer" in ovarian cancer and to assess its effects on tumor suppressor genes (TSG) and chemoresponsiveness-associated genes silenced by DNA methylation in ovarian cancer.
Azab, Mohammad +15 more
core +1 more source
Clinical Case Reports, 2020 The genomic landscape of AITL is characterized by mutation of epigenetic modifiers. This gene expression pattern resembles myeloid diseases and shows a potential role for hypomethylating agents as possible therapy for AITL.
Isabel Iturrate +7 more
doaj +1 more source
Myelodysplastic syndromes: Where do we stand?
Asian Journal of Oncology, 2016 Myelodysplastic syndromes (MDS) are fairly common hematological disorder of elderly. They are a group of clonal malignant hematopoietic stem cell disorders characterized by dysplastic morphology, variable cytopenia and a variable threat of transformation
Nitin Sood +5 more
doaj +1 more source
Epigenetic targeting of ovarian cancer stem cells [PDF]
, 2014 Emerging results indicate that cancer stem-like cells contribute to chemoresistance and poor clinical outcomes in many cancers, including ovarian cancer.
Cardenas, Horacio +8 more
core +2 more sources