Results 61 to 70 of about 69,158 (295)
Clinical Pharmacology in Drug Development, EarlyView.Abstract Endogenous oxytocin plays an important role in lactation, but its effectiveness as an exogenous galactagogue has been modest due to dose‐limiting side effects related to off‐target effects at the vasopressin V2 receptor. Merotocin (FE 202767) is a short‐acting peptidic oxytocin receptor agonist with the potential to aid mothers experiencing ...
Yu Bagger +4 more
wiley +1 more source
Disturbances of sodium in critically ill adult neurologic patients: A clinical review [PDF]
, 2006 Disorders of sodium and water balance are common in critically ill adult neurologic patients. Normal aspects of sodium and water regulation are reviewed. The etiology of possible causes of sodium disturbance is discussed in both the general inpatient and
Crocker, M +3 more
core
Etiology, Clinical Approach, and Therapeutic Consequences of Hyponatremia
Kidney and DialysisA perturbation in the water balance rather than any change in salt content is the main cause of hyponatremia, the most frequent electrolyte abnormality, defined as a serum sodium concentration 120 mEq/L) or severe (Na < 120 mEq/L) hyponatremia, and is ...
Goce Spasovski
doaj +1 more source
Association of hyponatremia with bone mineral density and fractures: a narrative review
Therapeutic Advances in Endocrinology and Metabolism, 2023 Recent studies suggest a possible association of hyponatremia with osteoporosis, falls and bone fractures. The objectives of this narrative review were to further explore this association and the related pathophysiological mechanisms and to suggest a ...
Ploutarchos Tzoulis +1 more
doaj +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams +7 more
wiley +1 more source
Adverse reactions of amiodarone [PDF]
, 2019 Adverse drug reaction is defined by the World Health Organization as any response to a drug that is noxious and unintended and occurs at a dose normally used in man.
Calvosa, Leonardo +5 more
core +1 more source
Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma
Medicina, 2021 Background and Objectives: Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and ...
Katharina Jäckle +6 more
doaj +1 more source
Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy
ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo +7 more
wiley +1 more source
JK Science, 2021 Background: Community-acquired pneumonia (CAP) is one of the most common infectious diseases and is an important cause of mortality and morbidity worldwide. Studies have shown hyponatremia to be a common electrolyte abnormality in pneumonia. The current
Mumina Ramzan +2 more
doaj
Hyponatremia in Liver Cirrhosis
The Korean Journal of Gastroenterology, 2018 Hyponatremia is a commonly observed complication that is related to hypoalbuminemia and portal hypertension in patients with advanced liver cirrhosis. Hyponatremia in patients with liver cirrhosis is mostly dilutional hyponatremia and is defined when the
Cheolmin Jang, Young Kul Jung
doaj +1 more source