Results 91 to 100 of about 9,342 (275)

Targeted Alkaline Phosphatase Therapy Enhances Alveolar Bone Healing in X‐Linked Hypophosphatemia in Mice

Journal of Periodontal Research, EarlyView.
Effects of exogenous tissue‐nonspecific alkaline phosphatase (TNAP) were analyzed in the Hyp mouse model of X‐linked hypophosphatemia (XLH). Maxillary first molars were extracted from wild‐type (WT) and Hyp mice at 6 weeks, and collagen gel ± TNAP was placed in sockets. In one group of Hyp mice, submucosal injections of TNAP or saline were delivered at
Aonjittra Phanrungsuwan, Bella Donnelly, José Luis Millán, Brian L. Foster   +3 more
wiley   +1 more source

Hypophosphatasia: Phenotypic Variability and Possible Croatian Origin of the c.1402G>A Mutation of TNSALP Gene [PDF]

, 2009
Hypophosphatasia is a metabolic bone disease characterized by bone and teeth hypomineralization due to defective function of tissue-nonspecific alkaline phosphatase (TNSALP).
Danijela Petkovi}, Davor Begovi}, Etienne Mornet, Feodora Stipoljev, Ivo Bari}, Kristina Poto~ki, Ksenija Fumi}, Ramad `, Vladimir Sarnavka   +8 more
core   +1 more source

Acidosis Is a Key Regulator of Osteoblast Ecto-Nucleotidase Pyrophosphatase/Phosphodiesterase 1 (NPP1) Expression and Activity [PDF]

, 2015
Previous work has shown that acidosis prevents bone nodule formation by osteoblasts in vitro by inhibiting mineralisation of the collagenous matrix.
Arnett, T R, Hajjawi, M O R, Key, M L, Millan, J L, Orriss, I R   +4 more
core   +2 more sources

Safety, pharmacokinetics, and pharmacodynamics of efzimfotase alfa, a second-generation enzyme replacement therapy: phase 1, dose-escalation study in adults with hypophosphatasia

Journal of Bone and Mineral Research
Hypophosphatasia (HPP) is a rare, inherited metabolic disease caused by deficient activity of tissue-nonspecific alkaline phosphatase (TNSALP). Efzimfotase alfa (ALXN1850) is a second-generation TNSALP enzyme replacement therapy in development for HPP ...
K. Dahir, Amy Shannon, Derek Dunn, W. Voegtli, Qunming Dong, Jawad Hasan, Rajendra Pradhan, Ryan Pelto, Wei-Jian Pan   +8 more
semanticscholar   +1 more source

Hypophosphatasia [PDF]

Archives of Disease in Childhood, 1957
A M, MACDONALD, R A, SHANKS
  +6 more sources

The Clinical Picture of Patients Suffering from Hypophosphatasia—A Rare Metabolic Disease of Many Faces

Diagnostics, 2022
Hypophosphatasia (HPP) is a rare, and usually diagnosed with delay, genetic disease caused by a mutation in the alkaline phosphatase liver/bone/kidney type (ALPL) gene.
Izabela Michałus, Aneta Gawlik, Katarzyna Wieczorek-Szukała, Andrzej Lewiński   +3 more
doaj   +1 more source

Detection of early osteogenic commitment in primary cells using Raman spectroscopy [PDF]

, 2017
Major challenges in the development of novel implant surfaces for artificial joints include osteoblast heterogeneity and the lack of a simple and sensitive in vitro assay to measure early osteogenic responses.
Clarkin, C E, Emery, R, Mahajan, S, Pitsillides, A A, Smith, S J   +4 more
core   +1 more source

The oral microbiota and periodontal health in orthodontic patients

Periodontology 2000, EarlyView.
Abstract The oral microbiota develops within the first 2 years of childhood and becomes distinct from the parents by 4 years‐of‐age. The oral microbiota plays an important role in the overall health/symbiosis of the individual. Deviations from the state of symbiosis leads to dysbiosis and an increased risk of pathogenicity.
Brandon W. Peterson, Geerten‐Has Tjakkes, Anne‐Marie Renkema, David J. Manton, Yijin Ren   +4 more
wiley   +1 more source

Could Some Patients With Fibromyalgia Potentially Have Hypophosphatasia? A Retrospective Single‐Center Study

ACR Open Rheumatology, 2023
Hypophosphatasia (HPP) is a rare disease characterized by incomplete or defective bone mineralization due to a mutation in the alkaline phosphatase (ALP) gene causing low levels of ALP.
Patil A Injean, John Tan, Sandy Lee, Christina Downey   +3 more
semanticscholar   +1 more source

FGF2 promotes Msx2 stimulated PC‐1 expression via Frs2/MAPK signaling [PDF]

, 2010
PC‐1 is an enzymatic generator of pyrophosphate and a critical regulator of tissue mineralization. We previously showed that fibroblast growth factor‐2 (FGF2) specifically induces PC‐1 expression in calvarial pre‐osteoblasts and that this occurs via a ...
Hatch, Nan E., Hudson, Mark, Kim, Sungsu, Li, Yan, Liu, Jin   +4 more
core   +1 more source