Results 41 to 50 of about 187,796 (197)

Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Calcium phosphate biomineralization has traditionally been considered a protein‐regulated process. This review highlights the emerging role of nucleic acids, which interact with mineral phases through adsorption, coprecipitation, and templating, thereby influencing crystal nucleation and growth.
Fanny Duhalde, Jessem Landoulsi, Xavier Houard   +2 more
wiley   +1 more source

Familial hypophosphatemic rickets

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2010
Rickets is the failure of mineralization of osteoid and newly formed bones in a child skeleton. It is commonly associated with vitamin D deficiency; however, it can be because of a decrease in the serum phosphate levels leading to inadequate ...
Sattur A, Naikmasur V, Shrivastava R, Babshet M   +3 more
doaj  

Vimseltinib for patients with tenosynovial giant cell tumor: A multicenter, open‐label, phase 2 trial

Cancer, Volume 132, Issue 17, 1 September 2026.
Abstract Background Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm caused by dysregulation of the colony‐stimulating factor 1 (CSF1) gene. Patients report substantial pain, stiffness, and declining physical function; those whose disease is not amenable to surgery require systemic therapy.
Silvia Stacchiotti, Jean‐Yves Blay, Piotr Rutkowski, Hans Gelderblom, Alejandro Falcón, Axel Le Cesne, Jayesh Desai, Emanuela Palmerini, César Serrano, Kristen N. Ganjoo, Gina Z. D’Amato, Christopher W. Ryan, Breelyn A. Wilky, Virginia Ferraresi, Ramy Saleh, Vinod Ravi, Albiruni Abdul Razak, Antonio Casado Herráez, Mahbubl Ahmed, Nicholas M. Bernthal, Michiel van de Sande, Mehdi Brahmi, Bartlomiej Szostakowski, Jasmine Sen, Nicholas A. Zeringo, Brooke Harrow, Supraja Narasimhan, Amanda Saunders, Maitreyi G. Sharma, Matthew L. Sherman, Andrew J. Wagner, William D. Tap   +31 more
wiley   +1 more source

Type 5 Diabetes Mellitus: Pathophysiology, Clinical Phenotype, and Nutritional Management

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Type 5 Diabetes Mellitus (T5DM) is an emerging diabetes phenotype linked to chronic undernutrition. It predominantly affects young, lean individuals in low‐ and middle‐income countries. After its formal recognition by the International Diabetes Federation in 2025, T5DM resurfaced as a clinically relevant insulin‐deficient phenotype.
İrem Nur Şahin Anılgan, Aslıhan Atar‐Uğurlu   +1 more
wiley   +1 more source

Hypophosphatemia Associated with Intravenous Iron Therapies for Iron Deficiency Anemia: A Systematic Literature Review

, 2020
John A Glaspy,1 Michelle Z Lim-Watson,2 Michael A Libre,3 Swagata S Karkare,3 Nandini Hadker,3 Aleksandra Bajic-Lucas,2 William E Strauss,2 Naomi V Dahl2 1UCLA School of Medicine, Los Angeles, CA, USA; 2AMAG Pharmaceuticals, Inc., Waltham, MA, USA ...
Glaspy JA, Hadker N, Bajic-Lucas A, Lim-Watson MZ, Karkare SS, Libre MA, Strauss WE, Dahl NV   +7 more
core  

Familial Ménière's disease: clinical and genetic aspects [PDF]

, 2009
Background and purpose:Mre's disease is not uncommon, with an incidence in Caucasians of about one in 2000. The incidence peaks in the fifth decade. Cases are usually isolated or sporadic, but in perhaps five per cent other family members are affected ...
Morrison, A W, Morrison, G A J, Bailey, M.E.S.   +2 more
core   +1 more source

Hypophosphatemic Rickets in Patients from Bichoric Biamniotic Twins: A Case Report

Педиатрическая фармакология
Background. X-linked dominant hypophosphatemic rickets (X-linked hypophosphatemia, XLH) is a disease caused by mutations in the PHEX gene (located at the Xp22.1 locus), which encodes an enzyme bound to the cell surface that cleaves the protein phosphate ...
Anna S. Nechaeva, Emma S. Grigoryan, Tatyana V. Turti, Tatiana E. Privalova, Nato D. Vashakmadze, Nina A. Krasnoshchekova   +5 more
doaj   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Importance about use of high-throughput sequencing in pediatric: case report of a patient with Fanconi-Bickel syndrome

BMC Pediatrics
Background Fanconi-Bickel syndrome is characterized by hepatorenal disease caused by anomalous glycogen storage. It occurs due to variants in the SLC2A2 gene.
Hugo Hernán Abarca-Barriga, María Cristina Laso-Salazar, Diego Orihuela-Tacuri, Jenny Chirinos-Saire, Anahí Venero-Nuñez   +4 more
doaj   +1 more source

Costello Syndrome Associated With Somatic Mosaicism of Rare p.Gly13Asp HRAS Variant: Expanding the Phenotypic Spectrum

Molecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.
We report a case of a 22‐year‐old woman with predominantly cutaneous involvement in whom whole‐exome sequencing from both blood‐ and hair‐derived DNA samples identified somatic mosaicism for the rare HRAS p.Gly13Asp variant. This case expands the phenotypic spectrum of Costello syndrome and underscores the importance of multitissue genomic analysis ...
Jovan Lalosevic, Katarina Djordjevic, Mirjana Gajic‐Veljic, Sonja Pavlovic, Vladimir Gasic, Marina Andjelkovic, Milos Nikolic   +6 more
wiley   +1 more source