Results 71 to 80 of about 3,965 (174)

A Phase II Pilot Study of Anti‐PD‐L1, Durvalumab, and a PARP Inhibitor, Olaparib in Patients With Metastatic Triple‐Negative Breast Cancer With or Without Germline BRCA Mutation

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Immunostimulatory effects of PARP inhibitors could increase sensitivity to immune checkpoint inhibitors. The previous Phase II trial (MEDIOLA) reported clinical benefits of durvalumab and olaparib (D + O) in patients with germline BRCA‐mutated (gBRCAm) HER2‐negative metastatic breast cancer.
Takeo Fujii, Ashley Cimino‐Mathews, Stanley Lipkowitz, Min‐Jung Lee, Jayakumar Nair, Britanny Brooke Solarz, Alexandra Zimmer, Bernadette Redd, Elliot B. Levy, Shraddha Rastogi, Nahoko Sato, Ann McCoy, Seth M. Steinberg, Jung‐Min Lee   +13 more
wiley   +1 more source

Treatment of Peripheral Precocious Puberty [PDF]

, 2015
There are many etiologies of peripheral precocious puberty (PPP) with diverse manifestations resulting from exposure to androgens, estrogens, or both. The clinical presentation depends on the underlying process and may be acute or gradual.
Eugster, Erica A., Schoelwer, Melissa
core   +1 more source

A Phase 1 Trial of Fimepinostat in Children and Adolescents With Relapsed and Refractory Solid and CNS Tumors

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Fimepinostat, an oral dual inhibitor of histone deacetylase (HDAC) and phosphatidylinositol‐4,5‐bisphosphate 3‐kinase (PI3K), has shown activity in preclinical models of Myc‐driven pediatric malignancies. This Phase 1 trial aimed to determine the recommended pediatric Phase 2 dose (RPP2D), describe the toxicity profile, and evaluate
David S. Shulman, Kieuhoa T. Vo, Frank M. Balis, Holly Lindsay, Rochelle Bagatell, Andrew E. Place, Susan N. Chi, Suzanne Shusterman, Suzanne Ezrre, Jeffrey Czaplinski, Ketki Bhushan, Pei‐Chi Kao, Wendy B. London, Steven G. DuBois   +13 more
wiley   +1 more source

Unmasking Hereditary Fructose Intolerance: Turning a Rare Diagnosis Into a Path for Healing

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Early diagnosis of children with hereditary fructose intolerance, which can be achieved by proper history taking, thorough clinical examination, response to diet, and histopathological examination, followed by effective management with a lifelong fructose, sucrose, and sorbitol‐free diet, ensures good prognosis and normal life.
Rajat Kumar Shah, Sajjad Ahmed Khan, Bijita Aryal, Aakash Khatiwada, Binita Gurubacharya, Shamin Parajuli   +5 more
wiley   +1 more source

Beyond Nutritional Deficiency: Persistent Rickets as a Manifestation of Vitamin D‐Dependent Rickets Type II in a Toddler

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Vitamin D‐dependent rickets type II (VDDR‐II) is a rare hereditary disorder caused by mutations in the vitamin D receptor gene, resulting in resistance to active vitamin D and impaired calcium absorption. We report a 2‐year and 6‐month‐old female toddler presenting with persistent rickets, delayed motor milestones, dental abnormalities, and ...
Abhisek Jha, Anil Yadav, Uma Shankar Jha, Preethuja Shah, Rohan Kumar Shah, Kuldeep Timilsina, Prabha Jha, Aabish Dahal, Saugat Bagale   +8 more
wiley   +1 more source

Molecular cloning of ion channels in Felis catus that are related to periodic paralyses in man: a contribution to the understanding of the genetic susceptibility to feline neck ventroflexion and paralysis [PDF]

, 2014
Neck ventroflexion in cats has different causes; however, the most common is the hypokalemia associated with flaccid paralysis secondary to chronic renal failure.
Castillo, Victor A., Dias-da-Silva, Magnus Régios, Kunii, Ilda Shizue, Maciel, Rui Monteiro de Barros, Paninka, Rolf M., Reche, Archivaldo, Simoes, Denise M. N., Zapata, Marlyn   +7 more
core   +4 more sources

Renal Fanconi Syndrome and Hypophosphatemic Rickets in the Absence of Xenotropic and Polytropic Retroviral Receptor in the Nephron. [PDF]

, 2017
Tight control of extracellular and intracellular inorganic phosphate (Pi) levels is critical to most biochemical and physiologic processes. Urinary Pi is freely filtered at the kidney glomerulus and is reabsorbed in the renal tubule by the action of the ...
Baron, R., Gautschi, I., Haenzi, B., Hu, D.Z., Katanaev, V., Katanaeva, N., Koesters, R., Nikolaeva, S., Pradervand, S., Rotman, S., Schild, L.   +10 more
core   +1 more source

Pharmacogenomic and structural analysis of constitutive G-protein coupled receptor activity [PDF]

, 2007
Premi a l'excel·lència investigadora. Àmbit de les Ciències de la Salut. 2008G-protein coupled receptors (GPCRs) respond to a chemically diverse plethora of signal transduction molecules.
Aldo Jongejan, Alewijnse AE, Ariens EJ, Brown EM, Cesarman E, Chen F, Clark AJ, Clark AJ, Cobbs CS, Furchgott RF, Furchgott RF, Garcia-Borron JC, Henk Timmerman, Henry F. Vischer, Leonardo Pardo, Mannstadt M, Martine J. Smit, Murphy PM, Nauta WT, Rauser L, Reiter EO, Remko A. Bakker, Rob Leurs, Rossier O, Samama P, Scheer A, Stephenson RP, Tabs S, Weiner DM, Wieland K   +29 more
core   +3 more sources

What are the causes of hypomagnesemia? [PDF]

, 2005
The causes of magnesium depletion and hypomagnesemia are decreased gastrointestinal (GI) absorption and increased renal loss. Decreased GI absorption is frequently due to diarrhea, malabsorption, and inadequate dietary intake.
Latessa, Robyn A., Mouw, David R., Sullo, Elaine J.   +2 more
core  

Penyakit Ginjal Kronis pada Anjing dan Kucing: Manajemen Terapi dan Diet [PDF]

, 2017
Chronic kidney disease is a progressive impairment of renal function and irreversible. The kidneys fail to maintain metabolism and fluid and electrolyte balance, causing uremia.
Indarjulianto, S. (Soedarmanto), Nururrozi, A. (Alfarisa), Yanuartono, Y. (Yanuartono)   +2 more
core   +3 more sources