Results 11 to 20 of about 1,450 (179)

Splenic structural and functional abnormalities in individuals with NR5A1/SF-1 variants [PDF]

Endocrine Connections
Purpose: Steroidogenic factor 1 (SF-1), encoded by NR5A1, is essential for spleen development and function. NR5A1 variants have been linked to abnormal spleen development.
Khadidja Fouatih, Camille Roussel, Maryse Cartigny, Muriel Houang, Lise Duranteau, Zeina Chakhtoura, Anne-Sophie Lambert, Marie-Agathe Trouvin, Barbara Girerd, Ekaterina Belozertseva, Delphine Borgel, Stephanie Franchi-Abella, Jérôme Bouligand, Maureen Lopez, Kenneth Chappell, Pierre Buffet, Ines Belguith, Claire Bouvattier, Abd El Kader Ait Tayeb   +18 more
doaj   +3 more sources

Autosplenectomy in a Patient With Autoimmune Polyglandular Syndrome Type 2 (APS-2) [PDF]

Case Reports in Endocrinology
Autoimmune glandular syndrome type 2 is a complex genetic condition where a triad of endocrinopathies is involved, namely, Addison’s disease, type 1 diabetes, and/or autoimmune thyroid disorder.
Luqman S. Fauzi, Airin Jyoty, Yashwin Sredharan, Manohara Kenchaiah   +3 more
doaj   +3 more sources

Impaired IgM Memory B Cell Function Is Common in Coeliac Disease but Conjugate Pneumococcal Vaccination Induces Robust Protective Immunity [PDF]

Vaccines
Coeliac disease (CD) is associated with hyposplenism, an acquired impairment of spleen function associated with reduced IgM memory B cells and increased susceptibility to serious pneumococcal infection.
Olivia G. Moscatelli, Amy K. Russell, Lee M. Henneken, Melinda Y. Hardy, Nadia Mazarakis, Rachel Higgins, Jesse Ekin, Harry McLeod, Paul Simkin, Paul V. Licciardi, Vanessa L. Bryant, Jason A. Tye-Din   +11 more
doaj   +4 more sources

Hyposplenism and Gastrointestinal Diseases: Significance and Mechanisms [PDF]

Digestive Diseases, 2021
<b><i>Background:</i></b> Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders.
Abhinav Mathur, Mairi H. McLean, Huan Cao, Mark A. Vickers   +3 more
openaire   +5 more sources

Hyposplenism as a cause of pneumococcal meningoencephalitis in an adult patient with coeliac disease

Italian Journal of Medicine, 2013
Introduction: Coeliac disease can be associated with hyposplenism and splenic atrophy, which may increase the patient’s risk for fatal infections caused by Streptococcus pneumoniae or Pneumococcus.
Paolo Caraceni, Barbara Benazzi, Giacono Caio, Giacomo Zaccherini, Marco Domenicali, Umberto Volta   +5 more
doaj   +2 more sources

Epidemiology and Characterization of Immunological Disorders in Children Diagnosed With Pneumococcal Invasive Disease. [PDF]

Int J Pediatr
Aim A substantial proportion of children hospitalized with invasive pneumococcal infection are subjected to immune evaluations, to detect immunological disorders (ID). The literature lacks thorough analysis of the necessity and effectiveness of these evaluations for previously healthy children with such infections.
Shahar C, Livni G, Marcus N, Pasternak Y.   +3 more
europepmc   +2 more sources

Dextrocardia in Heterotaxy Syndrome (Polysplenia Variant) in a 36-Year-Old Ethiopian Woman: A Case Report and Literature Review. [PDF]

Case Rep Cardiol
Background Heterotaxy syndrome—polysplenia variant (left isomerism) with dextrocardia is a rare constellation of laterality defects characterized by left‐isomerism, multiple splenic nodules, and associated vascular and visceral anomalies. This report describes an adult Ethiopian woman who presented with nonspecific abdominal pain and was found to have ...
Tukeni KN, Dekema RJ, Shukri MK, Mohammed JY, Jima MD, Kebede ML.   +5 more
europepmc   +2 more sources

Hyposplenism in systemic lupus erythematosus: biological and radiological characteristics and its association with increased risk of infection [PDF]

RMD Open
Objective This study aimed to evaluate the prevalence of hyposplenism in patients with systemic lupus erythematosus (SLE) and its association with an increased risk of infection.Methods This single-centre study included patients with SLE who underwent a ...
Zahir Amoura, Alexis Mathian, Miguel Hie, Bruno Pereira, François Chasset, Raphael Lhote, Micheline Pha, Julien Haroche, Fleur Cohen Aubart, Matthias Papo, Ludovic Trefond, Samia Boussouar, Karim Maloum, Catherine Settegrana   +13 more
doaj   +2 more sources

Underrecognised Functional Hyposplenism Associated With Chronic Graft‐Versus‐Host Disease: A Case Report [PDF]

eJHaem
eJHaem, Volume 6, Issue 2, April 2025.
Kaori Uchino, Yuya Nakagami, Megumi Enotomoto, Nozomi Shimizu, Kenichi Kondo, Takahiro Yamamoto, Yukie Sugita, Hideshige Seki, Sakura Saigusa, Yusuke Iida, Saki Shinohara, Soichi Takasugi, Tomohiro Horio, Satsuki Murakami, Shohei Mizuno, Kazuhiro Ikegame, Ichiro Hanamura, Akiyoshi Takami   +17 more
doaj   +3 more sources

Protein S Enhances the Phagocytosis of Phosphatidylserine-Exposing Erythrocytes: Implications in Sickle Cell Disease. [PDF]

Am J Hematol
ABSTRACT The major anticoagulant Protein S (PROS1) also contributes to the phagocytosis of apoptotic cells by bridging exposed phosphatidylserine (PtdSer) to the MerTK receptor on macrophages (efferocytosis). Whether PROS1 is involved in the splenic clearance of PtdSer‐positive senescent and altered erythrocytes such as erythrocyte ghosts (eryghosts ...
Auditeau C, Fricot A, Gauthier R, Sissoko A, Cacan Z, Gounou C, Joseph L, Manceau S, Allali S, Dussiot M, Marin M, Lavergne A, Khamari M, Moog S, Bianchini E, Claer L, Laurance S, Brousse V, Eymieux S, Roingeard P, Amireault P, Trovati Maciel T, Brisson A, Buffet P, Saller F, Borgel D, Roussel C.   +26 more
europepmc   +2 more sources