Cutaneous alpha-synuclein deposition informs autonomic function in individuals with early-stage multiple system atrophy. [PDF]
Trujillo P +9 more
europepmc +1 more source
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz +2 more
wiley +1 more source
Stage-dependent clinical burden in hospitalized Parkinson's disease with a positive bedside orthostatic hypotension screen: a retrospective cross-sectional analysis. [PDF]
Ma H +5 more
europepmc +1 more source
Orthostatic Hypotension and Falls [PDF]
openaire +2 more sources
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji +6 more
wiley +1 more source
Mechanism-Based Therapy With Ampreloxetine for Neurogenic Orthostatic Hypotension in Multiple System Atrophy: A Randomized Withdrawal Trial. [PDF]
Freeman R +8 more
europepmc +1 more source
Adjunctive aripiprazole may provide modest improvements in lipid parameters and body weight in clozapine‐treated patients with schizophrenia, but evidence for glucose and waist circumference outcomes remains limited. Larger, long‐term randomized controlled trials are needed.
Avtaar Singh, Soban Sadiq
wiley +1 more source
Exercise-Associated Syncope: A Narrative Review of Pathophysiology, Clinical Classification, and the Diagnostic Role of the Head-Up Tilt Test. [PDF]
Asteguieta S, Lopez C, Diaz C.
europepmc +1 more source
Integrating Conventional and Emerging Approaches in Cardiovascular Risk Assessment and Management
Conventional risk factors (hypertension, dyslipidaemia, diabetes, smoking, obesity and physical inactivity) account for roughly 70% of population‐attributable cardiovascular risk and anchor a proposed three‐tier pathway: universal low‐cost assessment (Tier 1), selective testing such as hsCRP or PRS where it would change management (Tier 2) and resource‐
Sana Rasheed +4 more
wiley +1 more source
Postural orthostatic tachycardia syndrome in adolescents with ME/CFS - a case control study. [PDF]
Leone A +6 more
europepmc +1 more source

