Results 61 to 70 of about 42,294 (241)

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Penyidikan Efek Samping Haloperidol Dan Chlorpromazine : Studi Kasus Pada Pasien Rawat Inap Rumah Sakit Jiwa Daerah Dr. Amino Gondohutomo Semarang Periode 2005 [PDF]

, 2007
Haloperidol and chlorpromazine antipsycotic were used for broad and so long time. That drugs used could shown undesire side effect. Objective of this study was to investigate haloperidol and chlorpromazine side effect, especially was to know relative ...
susilowati, S. (sri)
core  

Cardiovascular Autonomic Dysfunction Is the Most Common Cause of Syncope in Paced Patients

Frontiers in Cardiovascular Medicine, 2019
Introduction: Syncope and orthostatic intolerance in paced patients constitute a common clinical dilemma. We, thus, aimed to determine the etiology of syncope and/or symptoms of orthostatic intolerance in paced patients.Methods: Among 1,705 patients with
Ekrem Yasa, Ekrem Yasa, Fabrizio Ricci, Fabrizio Ricci, Fabrizio Ricci, Hannes Holm, Hannes Holm, Torbjörn Persson, Olle Melander, Olle Melander, Richard Sutton, Richard Sutton, Artur Fedorowski, Artur Fedorowski, Viktor Hamrefors, Viktor Hamrefors   +15 more
doaj   +1 more source

Heart rate and blood pressure response improve the prediction of orthostatic cardiovascular dysregulation in persons with chronic spinal cord injury

Physiological Reports, 2020
Unstable blood pressure after spinal cord injury (SCI) is not routinely examined but rather predicted by level and completeness of injury (i.e., American Spinal Injury Association Impairment Scale AIS classification).
Siqi Wang, Jill M. Wecht, Bonnie Legg Ditterline, Beatrice Ugiliweneza, Matthew T. Maher, Alexander T. Lombard, Sevda C. Aslan, Alexander V. Ovechkin, Brielle Bethke, Jordan T. H. Gunter, Susan J. Harkema   +10 more
doaj   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Impairments in hemodynamic responses to orthostasis associated with frailty : results from The Irish Longitudinal Study on Ageing (TILDA) [PDF]

, 2018
Objectives To characterize the relationships between orthostatic blood pressure (BP) and heart rate recovery and frailty in an older population. Design Cross‐sectional study. Setting Two health centers in the Republic of Ireland.
Fan, Chie Wei, Finucane, Ciarán, Kenny, Rose Anne, O’Connell, Matthew, Romero-Ortuno, Roman, Savva, George M.   +5 more
core   +5 more sources

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Frequency Distribution of Orthostatic Hypotension, Nocturnal Hypertension, and Postprandial Hypotension in Patients with Parkinson's Disease: A Case- Control Study

مجله دانشکده پزشکی اصفهان, 2012
Background: Orthostatic hypotension is a common autonomic dysfunction in Parkinson's disease. Major hypotheses proposed in the etiology of orthostatic hypotension include sympathetic denervation and treatment with dopaminergic drugs.
Ahmad Chitsaz, Mohammad Saadatnia, Maliheh Khalili Bandali   +2 more
doaj  

Orthostatic Cerebral Hypoperfusion Syndrome (OCHOS)

Frontiers in Aging Neuroscience, 2016
Objective: Orthostatic dizziness without orthostatic hypotension is common but underlying pathophysiology is poorly understood. This study describes orthostatic cerebral hypoperfusion syndrome (OCHOS). OCHOS is defined by: 1) Abnormal orthostatic drop of
Peter eNovak
doaj   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source