Results 131 to 140 of about 359,117 (344)

Procedural Characteristics and Safety of Slender Percutaneous Coronary Intervention: Slender Is Better

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Objectives We aimed to examine the procedural characteristics and safety profile of slender percutaneous coronary interventions (PCI) using a 5 Fr or smaller sheath. Background Smaller catheter size has been associated with fewer complications in PCI.
Fuminobu Yoshimachi, Kyohei Yamaji, Shun Kohsaka, Yota Kawamura, Satoshi Kasai, Toshiharu Fujii, Hirofumi Nagamatsu, Kazushige Amano, Yuka Karasawa, Shinichiro Yamada, Yoshihisa Nakagawa, Yuji Ikari   +11 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Prophylactic, manually titrable variable rate norepinephrine infusion for prevention of hypotension during spinal anesthesia for cesarean section: A randomized, double blind, controlled study

Journal of Obstetric Anaesthesia and Critical Care
Background and Aims: Norepinephrine is recently being investigated for mitigation of spinal-induced hypotension. Our study aimed at evaluating the role of manually titrated infusion of norepinephrine in preventing hypotension in patients undergoing lower
Vikram Bedi, Chanchel Mary Thomas, Suman Goyet, Santosh Choudhary, Riyaz Ahamed Kader Batcha, Reena Verma   +5 more
doaj   +1 more source

E-infrastructures fostering multi-centre collaborative research into the intensive care management of patients with brain injury [PDF]

, 2009
Clinical research is becoming ever more collaborative with multi-centre trials now a common practice. With this in mind, never has it been more important to have secure access to data and, in so doing, tackle the challenges of inter-organisational data ...
Piper, I., Sinnott, R.O.
core  

An adolescent girl with signs and symptoms of anaphylaxis and negative immunologic workup: a case report. [PDF]

, 2020
BackgroundThe increasing incidence of allergies and allergic reactions among children and adults has become a major public health concern. The etiology of allergic reactions can often be confirmed based on a detailed history and supportive testing ...
Bauer, Maureen, Frank, Guido KW, Green, Sarah, Hicks, Allison, Hilsendager, Chelsea   +4 more
core  

Tocilizumab Dosing for Management of T Cell‐Engaging Bispecific Antibody‐Related CRS in Patients With R/R B‐Cell NHL

Clinical Pharmacology &Therapeutics, EarlyView.
Tocilizumab dosing for management of T cell‐engaging bispecific antibody‐related CRS in patients with R/R B‐cell NHL. The recent surge in T‐cell‐engaging and chimeric antigen receptor (CAR) T‐cell therapies is changing the landscape of cancer therapy.
Candice Jamois, David C. Turner, Leonid Gibiansky, Feifei Li, Jean‐Francois Menuet, Leonardo Roque Pereira, Linda Lundberg, Elena Guerini, David J. Carlile, James Relf, Michael C. Wei, Antonia Kwan, Nicolas Frey, Susan Grange   +13 more
wiley   +1 more source

Infant Death due to Cannabis Ingestion

Drug Testing and Analysis, EarlyView.
ABSTRACT A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness.
Donata Favretto, Antonello Cirnelli, Roberto Pertile, Raffaella Stimamiglio, Clara Cestonaro, Oriana Cuman, Anna Pagliaro, Fabio Mattiazzi, Cristina Basso, Maddalena Galeazzi   +9 more
wiley   +1 more source

The Physiological Basis for Vitamin C as a Potential Treatment for Sepsis [PDF]

, 2019
Accounting for one third of all hospital patient deaths in America, sepsis remains one of the most deadly and complicated conditions that healthcare providers treat.
Johnston, Jennifer
core   +1 more source

Lifileucel tumor‐infiltrating lymphocyte cell therapy in patients with unresectable or metastatic mucosal melanoma after disease progression on immune checkpoint inhibitors

Cancer Communications, EarlyView.
Harriet Kluger, Götz Ulrich Grigoleit, Sajeve Thomas, Evidio Domingo‐Musibay, Jason A Chesney, Miguel F Sanmamed, Theresa Medina, Mirjana Ziemer, Eric Whitman, Friedrich Graf Finckenstein, Brian Gastman, Jeffrey Chou, Xiao Wu, Giri Sulur, Rana Fiaz, Rongsu Qi, Amod A Sarnaik   +16 more
wiley   +1 more source

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source