Results 11 to 20 of about 7,020 (201)

Ontogenesis of Gonadotropin-Releasing Hormone Neurons: A Model for Hypothalamic Neuroendocrine Cell Development [PDF]

Frontiers in Endocrinology, 2013
The vertebrate hypothalamo-pituitary-gonadal (HPG) axis is the anatomical framework responsible for reproductive competence and species propagation.
Erica L Stevenson, Kristina M Corella, Wilson CJ Chung, Wilson CJ Chung   +3 more
doaj   +2 more sources

Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia [PDF]

, 2012
Background Glucocorticoids play a major role in the treatment of acute lymphoblastic leukaemia (ALL). However, supraphysiological doses may cause suppression of the hypothalamic-pituitary-adrenal (HPA) axis.
Abdu, Agwu, Albert, Bessho, Birkebaek, Böttner, Christensen, Cunha, Dickstein, Einaudi, Felder-Puig, Felner, Grimes, Henzen, Hettmannsperger, Hurwitz, Igarashi, Krasner, Kuperman, Laupacis, Lightner, Maghnie, Mahachoklertwattana, Nyhlén, Pawlaczyk, Petersen, Planey, Poele, Pruckner, Rao, Rix, Rubnitz, Schlaghecke, Shah, Shibata, Shulman, Silva, Tijn, Tordjman, Vanderschueren-Lodeweyckx, Waage, Wheeler   +41 more
core   +7 more sources

Investigating genotype‐to‐phenotype correlation in CHARGE syndrome by deep phenotyping and multiparametric clustering

Clinical Genetics, Volume 104, Issue 4, Page 466-471, October 2023., 2023
Unsupervised machine learning and clustering in patients with CHARGE syndrome revealed a tendency towards mild/atypical phenotypes due to very distal CHD7 variants. RNA studies detected bi‐allelic expression whatever the location of the variant, indicating absence of NMD.
Jérémy Dana, Guillaume Dorval, Christine Saint Martin, Kahina Belhous, Raphael Levy, Sandrine Marlin, Isabelle De Bie, Manon Mautret‐Godefroy, Antonio Rausell, Marlène Rio, Elise Boucher‐Brischoux, Tania Attié‐Bitach, Nathalie Boddaert, Véronique Pingault   +13 more
wiley   +1 more source

Condition of neuro-hormonal systems in traumatic brain injury and influence of Carbacetam

Patologìâ, 2017
Use of GABA-ergic modulators in the traumatic brain injury (TBI) is actively investigated; their positive influence on brain circulation, inhibition of glutamate excitotoxicity, decrease of free radical damage, improvement of metabolism and power supply ...
S. V. Ziablitsev, O. O. Starodubska
doaj   +1 more source

Behavioral, neurological, and psychiatric frailty of autobiographical memory

WIREs Cognitive Science, Volume 14, Issue 3, May/June 2023., 2023
The five long‐term memory systems and their assumed brain bases. Abstract Autobiographical‐episodic memory is considered to be the most complex of the five long‐term memory systems. It is autonoetic, which means, self‐reflective, relies on emotional colorization, and needs the features of place and time; it allows mental time traveling. Compared to the
Hans J. Markowitsch, Angelica Staniloiu
wiley   +1 more source

Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A. [PDF]

PLoS Biology, 2014
Neuropilin-1 (Nrp1) guides the development of the nervous and vascular systems, but its role in the mature brain remains to be explored. Here we report that the expression of the 65 kDa isoform of Sema3A, the ligand of Nrp1, by adult vascular endothelial
Paolo Giacobini, Jyoti Parkash, Céline Campagne, Andrea Messina, Filippo Casoni, Charlotte Vanacker, Fanny Langlet, Barbara Hobo, Gabriella Cagnoni, Sarah Gallet, Naresh Kumar Hanchate, Danièle Mazur, Masahiko Taniguchi, Massimiliano Mazzone, Joost Verhaagen, Philippe Ciofi, Sébastien G Bouret, Luca Tamagnone, Vincent Prevot   +18 more
doaj   +1 more source

Mendelian Disorders in an Interstitial Cystitis/Bladder Pain Syndrome Cohort

Advanced Genetics, Volume 4, Issue 1, March 2023., 2023
Exome data for 109 individuals with interstitial cystitis/bladder pain syndrome is analyzed for Mendelian disorders. Two genes identified within the cohort, ATP2C1 and ATP2A2, are associated with dermatological phenotypes. Further evaluation with larger numbers is needed, though genetically screening individuals with IC/BPS may be useful in diagnosing ...
Elicia Estrella, Shira Rockowitz, Marielle Thorne, Pressley Smith, Jeanette Petit, Veronica Zehnder, Richard N. Yu, Stuart Bauer, Charles Berde, Pankaj B. Agrawal, Alan H. Beggs, Ali G. Gharavi, Louis Kunkel, Catherine A. Brownstein   +13 more
wiley   +1 more source

Oxytocin at physiological concentrations evokes adrenocorticotropin (ACTH) release from corticotrophs by increasing intracellular free calcium mobilized mainly from intracellular stores. Oxytocin displays synergistic or additive effects on ACTH-releasing factor or arginine vasopressin-induced ACTH secretion, respectively [PDF]

, 1992
The potency of oxytocin (OT) in evoking ACTH secretion by isolated, superfused rat adenohypophyseal corticotrophs and its enhancement by CRF and arginine vasopressin (AVP) were analyzed.
Dayanithi, G., Föhr, K. J., Gratzl, Manfred, Link, H.   +3 more
core   +1 more source

Role of PACAP in female fertility and reproduction at gonadal level - recent advances

Frontiers in Endocrinology, 2012
Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide, first isolated from hypothalamic extracts, but later shown in peripheral organs, such as endocrine glands, gastrointestinal system, cardiovascular system and ...
Dora eReglodi, Andrea eTamas, Miklos eKoppan, Donat eSzogyi, Laura eWelke   +4 more
doaj   +1 more source

Organic Cation Transporter 3: A Cellular Mechanism Underlying Rapid, Non-Genomic Glucocorticoid Regulation of Monoaminergic Neurotransmission, Physiology, and Behavior [PDF]

, 2018
Corticosteroid hormones act at intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) to alter gene expression, leading to diverse physiological and behavioral responses.
Gasser, Paul J., Lowry, Christopher A.
core   +2 more sources