Results 91 to 100 of about 318,025 (287)

The DMHGABA Neurons Play a Crucial Role in The Regulation of Cold‐Induced White Adipose Browning through DMH to LPO Projection

Advanced Science, EarlyView.
GABAergic neurons in the dorsomedial hypothalamus (DMHGABA neurons) act as a key neuronal population controlling cold exposure‐induced white adipose tissue browning. DMHGABA neurons regulate the browning through DMH to the lateral preoptic area (LPO) projection.
Zhijie Su, Yujia Hou, Bingwei Wang, Qian Zhou, Wen Yang, Bingbing Guo, Chenyu Zhang, Miao Zhao, Xiaoning Yang, Jiarui Liu, Xiangyang Xie, Lihua Qin, Weiguang Zhang, Wei L. Shen, Ruimao Zheng   +14 more
wiley   +1 more source

Panic-like defensive behavior but not fear-induced antinociception is differently organized by dorsomedial and posterior hypothalamic nuclei of Rattus norvegicus (Rodentia, Muridae)

Brazilian Journal of Medical and Biological Research, 2012
The hypothalamus is a forebrain structure critically involved in the organization of defensive responses to aversive stimuli. Gamma-aminobutyric acid (GABA)ergic dysfunction in dorsomedial and posterior hypothalamic nuclei is implicated in the origin of ...
A.F. Biagioni, J.A. Silva, N.C. Coimbra
doaj   +2 more sources

MicroRNAs are involved in the hypothalamic leptin sensitivity

Epigenetics, 2018
The central nervous system monitors modifications in metabolic parameters or hormone levels (leptin) and elicits adaptive responses such as food intake and glucose homeostasis regulation. Particularly, within the hypothalamus, pro-opiomelanocortin (POMC)
Adel Derghal, Mehdi Djelloul, Myriam Azzarelli, Sébastien Degonon, Franck Tourniaire, Jean-François Landrier, Lourdes Mounien   +6 more
doaj   +1 more source

Vagal Blocking for Obesity Control : a Possible Mechanism-Of-Action [PDF]

, 2016
14 September 2016 Erratum to: Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action Helene Johannessen, David Revesz, Yosuke Kodama, Nikki Cassie, Karolina P Skibicka, Perry Barrett, Suzanne Dickson, Jens Holst, Jens Rehfeld, Geoffrey van ...
Adan, Roger, Barrett, Perry, Ben-Menachem, Elinor, Cassie, Nikki, Chen, Duan, Dickson, Suzanne, Holst, Jens, Johannessen, Helene, Kodama, Yosuke, Kulseng, Bård, Rehfeld, Jens, Revesz, David, Skibicka, Karolina P, van der Plasse, Geoffrey, Zhao, Chun-Mei   +14 more
core   +1 more source

Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2‐Mediated Mitochondrial Fusion and UCP1‐Mediated Lipid Browning in ccRCC

Advanced Science, EarlyView.
Thyroid hormone receptor β1 (TRβ) downregulation correlates with poor prognosis in clear cell renal cell carcinoma (ccRCC). Restoration of TRβ and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha suppresses tumor progression in ccRCC through Uncoupling protein 1 mediated tumor cell “slimming” and optic atrophy 1/mitofusin 2 ...
Xiangui Meng, Tiexi Yu, Fang Lv, Weiquan Li, Hongmei Yang, Xiaoping Zhang, Wen Xiao   +6 more
wiley   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Secretin-dependent signals in the ventromedial hypothalamus regulate energy metabolism and bone homeostasis in mice

Nature Communications
Secretin, though originally discovered as a gut-derived hormone, is recently found to be abundantly expressed in the ventromedial hypothalamus, from which the central neural system controls satiety, energy metabolism, and bone homeostasis.
Fengwei Zhang, Wei Qiao, Ji-an Wei, Zhengyi Tao, Congjia Chen, Yefeng Wu, Minghui Lin, Ka Man Carmen Ng, Li Zhang, Kelvin Wai-Kwok Yeung, Billy Kwok Chong Chow   +10 more
doaj   +1 more source

Seven-tesla magnetic resonance imaging of the nervus terminalis, olfactory tracts, and olfactory bulbs in COVID-19 patients with anosmia and hypogeusia

Frontiers in Radiology
IntroductionLinking olfactory epithelium to the central nervous system are cranial nerve 1, the olfactory nerve, and cranial nerve “0,” and the nervus terminalis (NT).
Claudia F. E. Kirsch, Claudia F. E. Kirsch, Claudia F. E. Kirsch, Syed Ali Khurram, Daniel Lambert, Puneet Belani, Puneet S. Pawha, Akbar Alipour, Shams Rashid, Mackenzie T. Herb, Sera Saju, Yijuan Zhu, Bradley N. Delman, Hung-Mo Lin, Priti Balchandani   +14 more
doaj   +1 more source

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

Recent Research on Mechanisms of Feeding Regulation in Chicks

The Journal of Poultry Science
Food intake affects poultry productivity. A complete understanding of these regulatory mechanisms provides new strategies to improve productivity. Food intake is regulated by complex mechanisms involving many factors, including the central nervous system,
Takaoki Saneyasu
doaj   +1 more source