Results 91 to 100 of about 245,222 (354)

Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression

Advanced Science, EarlyView.
Genome‐wide analyses indicate that reduced ventral diencephalon and thalamus volumes, along with decreased functional connectivity within the triple network (DMN/CEN/SN), are uniquely associated with the risk of major depression (MD) onset, compared to other similar severe psychiatric disorders.
Ming‐Min Xu, Nan Li, Yi‐Wen Lv, Wen‐Miao Yang, Zhi‐Yun Yu, Yi‐Min Zhang, Yu Guo, Xiao‐Yin Chen   +7 more
wiley   +1 more source

Oral supplementation with ginseng polysaccharide promotes food intake in mice

Brain and Behavior, 2019
Introduction Ginseng polysaccharide (GPS, same as Panax polysaccharide) is a kind of polysaccharide extracted from ginseng. It has been reported that GPS has the ability to activate innate immunity, regulates blood sugar balance, and improves antioxidant
Jiawen Wang, Yongxiang Li, Pei Luo, Yuhuang Chen, Qianyun Xi, Hanyu Wu, Weijie Zhao, Gang Shu, Songbo Wang, Ping Gao, Xiaotong Zhu, Yongliang Zhang, Qingyan Jiang, Lina Wang   +13 more
doaj   +1 more source

Optogenetic identification of a rapid-eye-movement (REM) sleep modulatory circuit in the hypothalamus

Nature Neuroscience, 2013
Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, but their effects on REM ...
S. Jego, S. Glasgow, C. G. Herrera, Mats I. Ekstrand, S. Reed, Richard Boyce, J. Friedman, D. Burdakov, A. Adamantidis   +8 more
semanticscholar   +1 more source

Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep

Advanced Science, EarlyView.
The Hu sheep diverged from the Small‐tailed Han sheep ≈1330 years ago, and subsequently migrated from northern to warm and humid southern regions. The genes BMPR1B, UNC5C, and GRID2 play a synergistic role in the superior reproductive traits of Hu sheep.
Zexuan Liu, Na Zhang, Zilong Wen, Haitao Wang, Tingting Li, Runlin Ma, Menghua Li, Daxiang Wang, Haiping Shu, Xun Huang, Jianlin Han, Yiqiang Zhao, Qiuyue Liu   +12 more
wiley   +1 more source

Comparative Single‐Cell Transcriptomic Landscape Reveals the Regulatory Mechanisms of Lactation during Selective Breeding in Asian Water Buffalo

Advanced Science, EarlyView.
In this study, a comprehensive single‐cell transcriptome atlas of river and swamp buffalo, encompassing 12 tissues and 397,011 cells, is constructed. Differential expression analyses identify metabolic and secretory tissues and cell types that mediate the divergence of milk production.
Dongmei Dai, Jingfang Si, Li Jiang, Bo Han, Kailai Wang, Xue Wang, Shihui Yan, Yichang Yin, Wei Chen, Huaming Mao, Alfredo Pauciullo, Shang‐Tong Li, Lingzhao Fang, Yi Zhang   +13 more
wiley   +1 more source

Secretin-dependent signals in the ventromedial hypothalamus regulate energy metabolism and bone homeostasis in mice

Nature Communications
Secretin, though originally discovered as a gut-derived hormone, is recently found to be abundantly expressed in the ventromedial hypothalamus, from which the central neural system controls satiety, energy metabolism, and bone homeostasis.
Fengwei Zhang, Wei Qiao, Ji-an Wei, Zhengyi Tao, Congjia Chen, Yefeng Wu, Minghui Lin, Ka Man Carmen Ng, Li Zhang, Kelvin Wai-Kwok Yeung, Billy Kwok Chong Chow   +10 more
doaj   +1 more source

TDP-43 pathology in the basal forebrain and hypothalamus of patients with amyotrophic lateral sclerosis

Acta Neuropathologica Communications, 2014
IntroductionAmyotrophic lateral sclerosis is a neurodegenerative disease characterized clinically by motor symptoms including limb weakness, dysarthria, dysphagia, and respiratory compromise, and pathologically by inclusions of transactive response DNA ...
M. Cykowski, H. Takei, P. Schulz, S. Appel, S. Powell   +4 more
semanticscholar   +1 more source

Worth the Effort: Lessons for Discovery and Care From an Unusual Case of Gorlin Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gorlin‐Goltz Syndrome (GGS) is a rare autosomal dominant genetic disorder encompassing a diverse range of clinical manifestations, including congenital anomalies and predisposition to cancer. Pathogenic variants in PTCH1 and SUFU account for up to 79% and 6% of cases, respectively. Currently, an estimated 15%–27% of individuals with a clinical
V. Taliercio, J. Zhao, S. E. Boyden, R. Mao, P. Bayrak‐Toydemir, A. Pflaum, J. Palumbos, A. Andrews, E. E. Baldwin, C. Welt, Mackenzie Fait, Undiagnosed Diseases Network, L. D. Botto, D. Viskochil   +13 more
wiley   +1 more source

Energy imbalance alters Ca2+ handling and excitability of POMC neurons

eLife, 2017
Satiety-signaling, pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the hypothalamus play a pivotal role in the regulation of energy homeostasis.
Lars Paeger, Andreas Pippow, Simon Hess, Moritz Paehler, Andreas C Klein, Andreas Husch, Christophe Pouzat, Jens C Brüning, Peter Kloppenburg   +8 more
doaj   +1 more source

Case Report: Unusual Neurological Features of Leigh Syndrome due to m.8993T>G Pathogenic Variant in the MT‐ATP6 Gene

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel, Julie McLaughlin, Marta Frigeni   +2 more
wiley   +1 more source