Results 91 to 100 of about 204,951 (302)

Analysis of circular RNA (circRNA) characteristics and identification of key circRNAs in the hypothalamus during sexual maturation in female goats [PDF]

Animal Bioscience
Objective Precocious puberty can shorten reproductive cycles, enhance reproductive capacity, and reduce feeding costs. Consequently, precocious livestock are widely utilized in cross-breeding.
Qing Li, Jianmin Wang, Yanyan Wang, Peipei He, Lu Zhang, Tianle Chao   +5 more
doaj   +1 more source

The rate-limiting step for glucose transport into the hypothalamus is across the blood–hypothalamus interface [PDF]

, 2009
Specialized glucosensing neurons are present in the hypothalamus, some of which neighbor the median eminence, where the blood–brain barrier has been reported leaky.
Rolf Gruetter, HongXia Lei, Gruetter, R., Lei, Hongxia, Lei, H., Poitry-Yamate, C., Carol Poitry‐Yamate, Poitry-Yamate, Carole, Gruetter, Rolf   +8 more
core   +2 more sources

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Molecular Mechanism of Hypothalamus Development in Zebrafish [PDF]

, 2012
The hypothalamus is a key integrative center in the brain consisting of diverse cell types that differ in morphology and the neuropeptides they produce. These neuropeptides are required for the pivotal functions of the hypothalamus including homeostasis,
Wolf, Andrea, Wolf, A.
core   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Seven-tesla magnetic resonance imaging of the nervus terminalis, olfactory tracts, and olfactory bulbs in COVID-19 patients with anosmia and hypogeusia

Frontiers in Radiology
IntroductionLinking olfactory epithelium to the central nervous system are cranial nerve 1, the olfactory nerve, and cranial nerve “0,” and the nervus terminalis (NT).
Claudia F. E. Kirsch, Claudia F. E. Kirsch, Claudia F. E. Kirsch, Syed Ali Khurram, Daniel Lambert, Puneet Belani, Puneet S. Pawha, Akbar Alipour, Shams Rashid, Mackenzie T. Herb, Sera Saju, Yijuan Zhu, Bradley N. Delman, Hung-Mo Lin, Priti Balchandani   +14 more
doaj   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Recent Research on Mechanisms of Feeding Regulation in Chicks

The Journal of Poultry Science
Food intake affects poultry productivity. A complete understanding of these regulatory mechanisms provides new strategies to improve productivity. Food intake is regulated by complex mechanisms involving many factors, including the central nervous system,
Takaoki Saneyasu
doaj   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Hypothalamus

, 2017
The hypothalamus preserves body homeostasis by coordinating somatic, autonomic, and endocrine activity associated with ingestive, reproductive, and defensive ...
Alessandro Silvani, Giovanna Zoccoli
core   +1 more source