Results 101 to 110 of about 318,025 (287)
Development of TRH and TRH degrading activity(TRH-DA) in the hypothalamus and plasma of rats. [PDF]
, 1979 Sonia Aratan‐Spire +2 more
openalex +1 more source
Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice
Advanced Science, EarlyView.Microglial feimin deletion exacerbates lipotoxicity‐induced neuroinflammation and cognitive decline. In both in vitro and in vivo models, loss of feimin aggravated lipid droplet accumulation, IL‐1β/IL‐6 release, and neuronal injury through the PI3K–AKT–mTOR pathway, ultimately leading to severe neuronal apoptosis and cognitive impairment under high‐fat
Ran Gao +12 more
wiley +1 more source
AnimalsBroilers grown in a high-density (HD) stocking environment may experience intense competition that may adversely affect their growth relative to animals reared at a normal density (ND).
Xiaodie Zhao +13 more
doaj +1 more source
Molecules, 2018 Obesity is associated with modern diets that are rich in saturated fatty acids. These dietary patterns are linked to low-grade proinflammatory mechanisms, such as the toll-like receptor 4/nuclear factor kappa-B (NF-κB) pathway rapidly activated ...
Aline Boveto Santamarina +6 more
doaj +1 more source
Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy
Advanced Science, EarlyView.This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li +5 more
wiley +1 more source
Effects of damage to the suprachiasmatic area of the anterior hypothalamus on the daily melatonin and cortisol rhythms in the rhesus monkey [PDF]
, 1981 SM Reppert +7 more
openalex +1 more source
Effect of Sleeve Gastrectomy on Kisspeptin Expression in the Hypothalamus of Rats with Polycystic Ovary Syndrome [PDF]
, 2020 openalex +1 more source
Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases
Advanced Science, EarlyView.Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu +9 more
wiley +1 more source
Impact of Sleeve Gastrectomy on Body Weight and Food Intake Regulation in Diet-Induced Obese Mice
Current Issues in Molecular BiologyThe epidemic of obesity has increased worldwide and is associated with comorbidities such as diabetes and cardiovascular disease. In this context, strategies that modulate body weight and improve glycemic metabolism have increased, and bariatric ...
Sandra Lucinei Balbo +9 more
doaj +1 more source
Advanced Science, EarlyView.Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun +9 more
wiley +1 more source