The R18D peptide exhibits a favorable pharmacokinetic profile and significantly reduces infarct volume in a rat model of middle cerebral artery occlusion (MCAO) followed by reperfusion. These findings highlight the potential clinical utility of R18D as a neuroprotective therapy for stroke patients undergoing endovascular recanalization interventions ...
Bruno P. Meloni +10 more
wiley +1 more source
Clinical outcomes of totally thoracoscopic mitral valve reoperation with moderate hypothermia-induced ventricular fibrillation arrest. [PDF]
He X +8 more
europepmc +1 more source
From barrier dysfunction to metabolic paralysis: IAPA progression is characterized by a functional dissociation: the host experiences hyper‐inflammatory cytokine storms (IL‐1β, IFN‐λ) while simultaneously suffering from antimicrobial metabolic paralysis (loss of ROS and recognition). This creates a specific window for host‐directed therapies, including
Liangyu Li, Shuo Liang
wiley +1 more source
Atypical Clinical Presentation of Hypothermia Induced by Intrathecal Morphine in a Patient Who Underwent Total Knee Arthroplasty Under Spinal Anesthesia: A Case Report. [PDF]
Correa D +5 more
europepmc +1 more source
External cephalic version outcomes with tocolysis and sedation: A 10‐year retrospective cohort study
Abstract Objective To evaluate the effectiveness and safety of external cephalic version (ECV) performed with tocolysis and sedation or spinal anesthesia, and to identify predictors of ECV success, complications, and delivery outcomes after successful ECV. Methods This 10‐year cohort study included 990 pregnant women with term non‐cephalic presentation
Javier Sánchez‐Romero +7 more
wiley +1 more source
Accidental Hypothermia-Induced J Wave Coupled With Giant R Wave Augmented by Premature Atrial Contraction: A Case Report. [PDF]
Takahashi K +4 more
europepmc +1 more source
Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang +12 more
wiley +1 more source
Induced hypothermia after cardiac arrest [Elektronisk resurs]
Popular Abstract in Swedish Bakgrund: Nio av tio patienter som läggs in på sjukhus efter hjärtstillestånd utanför sjukhus är medvetslösa och behöver intensivvård. Dödligheten och risken för varaktiga hjärnskador är stor.
Lund University., Nielsen, Niklas,
core
Encephalopathy: Cause, Pathogenesis, and Treatment
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv +7 more
wiley +1 more source
A Case of Respiratory Arrest After Lung Cancer Surgery due to Recurarization of Rocuronium Bromide
An 82‐year‐old male lung cancer patient experienced respiratory arrest after surgery due to recurarization of rocuronium bromide. Considering that many lung cancer patients are elderly and have numerous comorbidities, the risk of recurarization associated with muscle relaxants should always be considered.
Hiroyuki Miura +3 more
wiley +1 more source

