Results 171 to 180 of about 43,432 (280)

Pharmacokinetics and Neuroprotective Efficacy of Poly‐Arginine Peptide R18D in Sprague Dawley Rats Subjected to Transient Intraluminal Filament Middle Cerebral Artery Occlusion Stroke

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
The R18D peptide exhibits a favorable pharmacokinetic profile and significantly reduces infarct volume in a rat model of middle cerebral artery occlusion (MCAO) followed by reperfusion. These findings highlight the potential clinical utility of R18D as a neuroprotective therapy for stroke patients undergoing endovascular recanalization interventions ...
Bruno P. Meloni   +10 more
wiley   +1 more source

Host immune collapse in influenza‐associated pulmonary aspergillosis: From barrier dysfunction to metabolic paralysis

open access: yesClinical and Translational Discovery, Volume 6, Issue 3, June 2026.
From barrier dysfunction to metabolic paralysis: IAPA progression is characterized by a functional dissociation: the host experiences hyper‐inflammatory cytokine storms (IL‐1β, IFN‐λ) while simultaneously suffering from antimicrobial metabolic paralysis (loss of ROS and recognition). This creates a specific window for host‐directed therapies, including
Liangyu Li, Shuo Liang
wiley   +1 more source

External cephalic version outcomes with tocolysis and sedation: A 10‐year retrospective cohort study

open access: yesInternational Journal of Gynecology &Obstetrics, Volume 173, Issue 3, Page 1343-1351, June 2026.
Abstract Objective To evaluate the effectiveness and safety of external cephalic version (ECV) performed with tocolysis and sedation or spinal anesthesia, and to identify predictors of ECV success, complications, and delivery outcomes after successful ECV. Methods This 10‐year cohort study included 990 pregnant women with term non‐cephalic presentation
Javier Sánchez‐Romero   +7 more
wiley   +1 more source

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

open access: yesMedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang   +12 more
wiley   +1 more source

Induced hypothermia after cardiac arrest [Elektronisk resurs]

open access: yes, 2010
Popular Abstract in Swedish Bakgrund: Nio av tio patienter som läggs in på sjukhus efter hjärtstillestånd utanför sjukhus är medvetslösa och behöver intensivvård. Dödligheten och risken för varaktiga hjärnskador är stor.
Lund University., Nielsen, Niklas,
core  

Encephalopathy: Cause, Pathogenesis, and Treatment

open access: yesMedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv   +7 more
wiley   +1 more source

A Case of Respiratory Arrest After Lung Cancer Surgery due to Recurarization of Rocuronium Bromide

open access: yesRespirology Case Reports, Volume 14, Issue 6, June 2026.
An 82‐year‐old male lung cancer patient experienced respiratory arrest after surgery due to recurarization of rocuronium bromide. Considering that many lung cancer patients are elderly and have numerous comorbidities, the risk of recurarization associated with muscle relaxants should always be considered.
Hiroyuki Miura   +3 more
wiley   +1 more source

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