Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat [PDF]
, 2004 Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and ...
Candelario-Jalil, Eduardo +4 more
core +1 more source
Hypothermia protects the brain from transient global ischemia/reperfusion by attenuating endoplasmic reticulum response-induced apoptosis through CHOP. [PDF]
PLoS ONE, 2013 Endoplasmic reticulum (ER) stress has been implicated in the pathology of cerebral ischemia. Apoptotic cell death occurs during prolonged period of stress or when the adaptive response fails.
Xiaojie Liu +7 more
doaj +1 more source
Abdominal trauma in dogs 2. management [PDF]
, 2018 Trauma represents a big challenge for emergency doctors both in human and veterinary medicine. There have been great advancements in trauma medicine in people and these often provide an inspiration for veterinary surgeons.
Cortellini, S, Humm, K R
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Journal of Neuroinflammation, 2018 Background Hypothermia is increasingly tested in several neurological conditions, such as neonatal encephalopathy, stroke, traumatic brain injury, subarachnoid hemorrhage, spinal cord injury, and neurological outcomes of cardiac arrest.
Mathilde Chevin +2 more
doaj +1 more source
The human burst suppression electroencephalogram of deep hypothermia [PDF]
, 2017 Objective: Deep hypothermia induces 'burst suppression' (BS), an electroencephalogram pattern with low-voltage 'suppressions' alternating with high-voltage 'bursts'.
Akeju, Oluwaseun +8 more
core +1 more source
Challenges of measuring body temperatures of free-ranging birds and mammals [PDF]
, 2015 The thermal physiology of most birds and mammals is characterised by considerable spatial and temporal variation in body temperature. Body temperature is, therefore, a key parameter in physiological, behavioural and ecological research.
Gallon, S., McCafferty, D.J., Nord, A.
core +2 more sources
Brain Sciences, 2015 Hypoxia induced endoplasmic reticulum stress causes accumulation of unfolded proteins in the endoplasmic reticulum and activates the unfolded protein response, resulting in apoptosis through CCAAT-enhancer-binding protein homologous protein (CHOP ...
Gagandip K. Poone +5 more
doaj +1 more source
Investigation of Perognathus as an Experimental Organism for Research in Space Biology Summary Progress Report, 3 Jan. - 30 Sep. 1967 [PDF]
Hypoxia induced hypothermia and hemoglobin oxygen affinity in ...
Lindberg, R. G.
core +1 more source
Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System. [PDF]
, 2016 The reduction of oxidative stress is suggested to be one of the main mechanisms to explain the benefits of subnormothermic perfusion against ischemic liver damage. In this study we investigated the early cellular mechanisms induced in isolated rat livers
Alva, Norma +4 more
core +4 more sources
Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors
Scientific Reports, 2012 Tau hyperphosphorylation is one hallmark of Alzheimer's disease (AD) pathology. Pharmaceutical companies have thus developed kinase inhibitors aiming to reduce tau hyperphosphorylation.
Alexis Bretteville +9 more
semanticscholar +1 more source