Results 71 to 80 of about 3,614,670 (301)

Printing‐Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling

Advanced Science, EarlyView.
Extrusion‐based 3D printing of silicones and discrete electronic components are combined to create cortical implants for rodents that integrate thermal neuromodulation and electrical recording. Linked to an autonomous auxiliary driver unit, the system enables rapid, stable and localized hypothermia alongside ECoG recording.
Spencer Ryan Moore, Naomi King, Aruã Clayton Da Silva, Clare Howarth, Jason Berwick, Thomas E. Paterson, Ivan R. Minev   +6 more
wiley   +1 more source

Cold Shock Induced Protein RBM3 but Not Mild Hypothermia Protects Human SH-SY5Y Neuroblastoma Cells From MPP+-Induced Neurotoxicity

Frontiers in Neuroscience, 2018
The cold shock protein RBM3 can mediate mild hypothermia-related protection in neurodegeneration such as Alzheimer's disease. However, it remains unclear whether RBM3 and mild hypothermia provide same protection in model of Parkinson's disease (PD), the ...
Hai-Jie Yang, Hai-Jie Yang, Xiang Shi, Fei Ju, Bei-Ning Hao, Shuang-Ping Ma, Lei Wang, Bin-Feng Cheng, Mian Wang   +8 more
doaj   +1 more source

Dexmedetomidine Use in Patients with 33℃ Targeted Temperature Management: Focus on Bradycardia as an Adverse Effect [PDF]

Korean Journal of Critical Care Medicine, 2015
Background This study aimed to investigate bradycardia as an adverse effect after administration of dexmedetomidine during 33℃ target temperature management.
Hyo-yeon Seo, Byoung-joon Oh, Eun-jung Park, Young-gi Min, Sang-cheon Choi   +4 more
doaj   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Hemoglobin concentration is associated with neurologic outcome after cardiac arrest in patients treated with targeted temperature management [PDF]

Clinical and Experimental Emergency Medicine, 2018
Objective The objective of this study was to test the hypothesis that hemoglobin concentration after return of spontaneous circulation (ROSC) is associated with neurologic outcome after cardiac arrest in patients treated with targeted temperature ...
Daesung Kim, Soo Hyun Kim, Kyu Nam Park, Sang Hoon Oh, Young Min Kim, Chun Song Youn   +5 more
doaj   +1 more source

The cold-inducible RNA-binding motif protein 3 (RBM3) prevents cell death through various mechanisms [PDF]

, 2016
Moderate hypothermia promotes the survival of neural cells in a wide range of brain disorders. During hypothermia, a subgroup of proteins including two homologues, RNA-binding motif protein 3 (RBM3) and cold-inducible RNA-binding protein (CIRP), is ...
Zhu, Xinzhou
core   +1 more source

An Environmental Stable Ionogel‐Based Smart Glove System for Integrated Underwater Communication and Safety Warning

Advanced Science, EarlyView.
This study develops a smart glove by integrating a P(BZMA‐co‐HEA)/IL ionogel with a reconfigurable FPCB for underwater communication and real‐time safety warning. The network‐constrained ionic soft‐space regulation strategy enables mechanical reliability, environmental stability, and sensing adaptability, while the modular FPCB sensor array simplifies ...
Xiaoqin Li, Jianwen Liu, Wenhao Yang, Wenjing Yue, Nam‐Young Kim, Young‐Kee Shin, Song Gao, Eun‐Seong Kim, Yang Li   +8 more
wiley   +1 more source

Pilot randomized trial of therapeutic hypothermia with serial cranial ultrasound and 18-22 month follow-up for neonatal encephalopathy in a low resource hospital setting in Uganda: study protocol [PDF]

, 2011
Background: There is now convincing evidence that in industrialized countries therapeutic hypothermia for perinatal asphyxial encephalopathy increases survival with normal neurological function. However, the greatest burden of perinatal asphyxia falls in
Allen, Elizabeth, Allen Elizabeth, Cornelia F Hagmann, Jacobs Ian, Hagmann, Cornelia F., Nakakeeto Margaret, Elbourne, Diana, Jacobs, Ian, Ian Jacobs, Costello, Anthony, Frances Cowan, Acolet Dominique, Nicola J Robertson, Acolet, Dominique, Anthony Costello, Cowan Frances, Cowan, Frances, Acolet, D, Elbourne, D, Nyombi, Natasha, Robertson, Nicola J., Hagmann Cornelia F, Dominique Acolet, Robertson Nicola J, Robertson, NJ, Diana Elbourne, Margaret Nakakeeto, Nyombi Natasha, Cowan, F, Jacobs, I, Costello, A, Nakakeeto, Margaret, Robertson, Nicola J, Elbourne Diana, Hagmann, Cornelia F, Nakakeeto, M, Elizabeth Allen, Hagmann, CF, Nyombi, N, Allen, E, Costello Anthony, Natasha Nyombi   +41 more
core   +2 more sources

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Effect of hypothermia on interleukin-1 receptor antagonist pharmacodynamics in inflammatory-sensitized hypoxic-ischemic encephalopathy of term newborns

Journal of Neuroinflammation, 2018
Background Hypothermia is increasingly tested in several neurological conditions, such as neonatal encephalopathy, stroke, traumatic brain injury, subarachnoid hemorrhage, spinal cord injury, and neurological outcomes of cardiac arrest.
Mathilde Chevin, Clémence Guiraut, Guillaume Sébire   +2 more
doaj   +1 more source