Results 51 to 60 of about 43,432 (280)

Cardioprotective Effect of Therapeutic Hypothermia for Postresuscitation Myocardial Dysfunction

open access: yes, 2011
Mild-to-moderate therapeutic hypothermia after resuscitation from cardiac arrest is neuroprotective, but its effect on postresuscitation myocardial dysfunction is not clear.
HSU, CHIUNG-YUAN;HUANG, CHIEN-HUA;CHANG, WEI-TIEN;CHEN, HUEI-WEN;CHENG, HSIAO-JU;TSAI, MIN-SHAN;WANG, TZUNG-DAU;YEN, ZUI-SHEN;LEE, CHIEN-CHANG;CHEN, SHYR-CHYR;CHEN, WEN-JONE   +1 more
core   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto   +20 more
wiley   +1 more source

Activation of mitochondrial STAT-3 and reduced mitochondria damage during hypothermia treatment for post-cardiac arrest myocardial dysfunction

open access: yes, 2017
While therapeutic hypothermia improves the outcomes of individuals in cardiac arrest, the hemodynamic responses and mechanisms which underlie hypothermia-induced cardioprotection are not fully understood. Therefore, we investigated the mechanism by which
Huang, Chien-Hua;Tsai, Min-Shan;Chiang, Chih-Yen;Su, Yu-Jen;Wang, Tzung-Dau;Chang, Wei-Tien;Chen, Huei-Wen;Chen, Wen-Jone   +1 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

open access: yesAdvanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak   +9 more
wiley   +1 more source

Management of Induced Hypothermia in the Intensive Care Unit

open access: yes
The use of hypothermia as a therapeutic modality for preventing secondary brain damage in traumatic brain injury, global brain ischemia, and stroke remains controversial.
Bullock, Ross, Doppenberg, Egon M. R
core   +2 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

open access: yesAdvanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong   +24 more
wiley   +1 more source

PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats

open access: yesJournal of Pharmacological Sciences, 2017
Therapeutic hypothermia is a promising strategy for acute cerebral ischemia via physical or pharmacological methods. In this study, we pharmacologically induced hypothermia on Sprague Dawley rats by intraperitoneally injecting PD149163.
Teng-Fei Xue   +7 more
doaj   +1 more source

The effect of hypothermia therapy on cortical laminar disruption following ischemic injury in neonatal mice. [PDF]

open access: yesPLoS ONE, 2013
Hypothermia has been proposed as a treatment for reducing neuronal damage in the brain induced by hypoxic ischemia. In the developing brain, hypoxic ischemia-induced injury may give rise to cerebral palsy (CP).
Hiroyuki Kida   +5 more
doaj   +1 more source

The cold-inducible RNA-binding motif protein 3 (RBM3) prevents cell death through various mechanisms [PDF]

open access: yes, 2016
Moderate hypothermia promotes the survival of neural cells in a wide range of brain disorders. During hypothermia, a subgroup of proteins including two homologues, RNA-binding motif protein 3 (RBM3) and cold-inducible RNA-binding protein (CIRP), is ...
Zhu, Xinzhou
core   +1 more source

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