Results 61 to 70 of about 3,614,670 (301)

Pharmacodynamic properties for inhibition of cAMP- and cGMP elimination by pentoxifylline remain unaltered in vitro during hypothermia

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2022
Background Rewarming from hypothermia is associated with severe complications, one of which is hypothermia-induced cardiac dysfunction. This condition is characterized by decreased cardiac output accompanied by increased total peripheral resistance. This
Anders Lund Selli, Adrina Kalasho Kuzmiszyn, Natalia Smaglyukova, Timofey Kondratiev, Ole-Martin Fuskevåg, Georg Sager, Erik Sveberg Dietrichs   +6 more
doaj   +1 more source

Distinct Cleavage Trajectories Mediated by DNA and RNA Substrate in Argonaute From Methanocaldococcus Fervens

Advanced Science, EarlyView.
This study characterizes MfAgo, an enzyme exhibiting highly efficient DNA‐guided DNA and RNA cleavage capability. Precise RNA cleavage strictly requires dimerization to stabilize the PIWI‐loop region, while its robust DNA cleavage functions in a dimerization‐independent manner.
Fuyong Huang, Taiyu Chen, Meng Fang, Qinmiao Duanmu, Kangle Mu, Yuqi Bi, Siwei Xu, Xin Tao, Jiening Wang, Shan Wu   +9 more
wiley   +1 more source

Cardioprotective Effect of Therapeutic Hypothermia for Postresuscitation Myocardial Dysfunction

, 2011
Mild-to-moderate therapeutic hypothermia after resuscitation from cardiac arrest is neuroprotective, but its effect on postresuscitation myocardial dysfunction is not clear.
HSU, CHIUNG-YUAN;HUANG, CHIEN-HUA;CHANG, WEI-TIEN;CHEN, HUEI-WEN;CHENG, HSIAO-JU;TSAI, MIN-SHAN;WANG, TZUNG-DAU;YEN, ZUI-SHEN;LEE, CHIEN-CHANG;CHEN, SHYR-CHYR;CHEN, WEN-JONE, 許瓊元;黃建華;張維典;陳惠文;鄭曉如;蔡旼珊;王宗道;顏瑞昇;李建璋;陳石池;陳文鍾   +1 more
core   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Mild hypothermia protects against radiation-induced intestinal injury in mice via upregulation of heme oxygenase-1

Journal of Radiation Research and Applied Sciences
Radiation can cause life-threatening intestinal damage, whether intentional or unintentional. The present study investigated the effects of mild hypothermia on radiation-induced intestinal injury and survival.
Bokyung Jung, Sohi Kang, Sohee Jeong, Mi-sook Kim, Won Il Jang, Min Ji Bae, Wol Soon Jo, Chang Geun Lee, Joong Sun Kim, Kwangmo Yang   +9 more
doaj   +1 more source

A case of successful pediatric heat stroke treatment using normothermic targeted temperature management [PDF]

Pediatric Emergency Medicine Journal
This case report describes a successful use of normothermic targeted temperature management (TTM) for the treatment of a 14-year-old girl with exertional heat stroke.
Seungjin Lee, Geun Seop Shin, Sang-I Kong, Yoseop Won, Young Dai Kwon, Jung Min Yoon, Kyoung Ok Ko, In Goo Lee, Jun Suk Oh   +8 more
doaj   +1 more source

Use of an external-cooling device for the treatment of heat stroke [PDF]

Clinical and Experimental Emergency Medicine, 2014
Heat stroke is caused by losing control of one’s body temperature. It can be life threatening without proper treatment. In this case report, we describe a heat stroke patient treated with an external-cooling device, which is commonly used for therapeutic
Byung-Chan Lee, Jung Youn Kim, Sung Hyuk Choi, Young Hoon Yoon   +3 more
doaj   +1 more source

α-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice [PDF]

, 2014
Hypothermia is a key symptom of sepsis, but the mechanism(s) leading to hypothermia during sepsis is largely unknown and thus no effective therapy is available for hypothermia.
Winnik, Witold, Alzate, Oscar, Xu, Longquan, Simington, Stephen, Yi, Xianwen, Hiller, Sylvia, Robinette, Jennifer, Maeda, Nobuyo, DeKroon, Robert   +8 more
core   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Nutritional management in newborn babies receiving therapeutic hypothermia: two retrospective observational studies using propensity score matching

Health Technology Assessment, 2021
Background: Therapeutic hypothermia is standard of care for babies with moderate to severe hypoxic–ischaemic encephalopathy. There is limited evidence to inform provision of nutrition during hypothermia.
Chris Gale, Dusha Jeyakumaran, Cheryl Battersby, Kayleigh Ougham, Shalini Ojha, Lucy Culshaw, Ella Selby, Jon Dorling, Nicholas Longford   +8 more
doaj   +1 more source