Results 11 to 20 of about 160,472 (245)

Metabolically Stable Neurotensin Analogs Exert Potent and Long-Acting Analgesia Without Hypothermia [PDF]

Behavioural Brain Research, 405:113189 (2021), 2021
The endogenous tridecapeptide neurotensin (NT) has emerged as an important inhibitory modulator of pain transmission, exerting its analgesic action through the activation of the G protein-coupled receptors, NTS1 and NTS2. Whereas both NT receptors mediate the analgesic effects of NT, NTS1 activation also produces hypotension and hypothermia, which may ...
arxiv   +1 more source

Difference between 5A score and the HOPE score

Journal of Intensive Care, 2022
Recently, a letter to the editor was published to comment on the 5A score which is the prediction model for accidental hypothermia patients comparing the HOPE score.
Yohei Okada, Tasuku Matsuyama, Kei Hayashida, Shuhei Takauji, Jun Kanda, Shoji Yokobori   +5 more
doaj   +1 more source

Accidental hypothermia: characteristics, outcomes, and prognostic factors—A nationwide observational study in Japan (Hypothermia study 2018 and 2019)

Acute Medicine & Surgery, 2021
Aim This study describes the clinical characteristics and outcomes as well as the prognostic factors of patients with accidental hypothermia (AH) using Japan’s nationwide registry data. Methods The Hypothermia study 2018 and 2019, which included patients
Shuhei Takauji, Toru Hifumi, Yasuaki Saijo, Shoji Yokobori, Jun Kanda, Yutaka Kondo, Kei Hayashida, Junya Shimazaki, Takashi Moriya, Masaharu Yagi, Junko Yamaguchi, Yohei Okada, Yuichi Okano, Hitoshi Kaneko, Tatsuho Kobayashi, Motoki Fujita, Keiki Shimizu, Hiroyuki Yokota   +17 more
doaj   +1 more source

External validation of 5A score model for predicting in-hospital mortality among the accidental hypothermia patients: JAAM-Hypothermia study 2018–2019 secondary analysis

Journal of Intensive Care, 2022
Background The 5A score including five components “Age, Activities of daily living, Arrest, Acidemia and Albumin” was developed as an easy-to-use screening tool for predicting in-hospital mortality among patients with accidental hypothermia. However, the
Yohei Okada, Tasuku Matsuyama, Kei Hayashida, Shuhei Takauji, Jun Kanda, Shoji Yokobori   +5 more
doaj   +1 more source

HSP70-mediated neuroprotection by combined treatment of valproic acid with hypothermia in a rat asphyxial cardiac arrest model.

PLoS ONE, 2021
It has been reported that valproic acid (VPA) combined with therapeutic hypothermia can improve survival and neurologic outcomes in a rat asphyxial cardiac arrest model. However, neuroprotective mechanisms of such combined treatment of valproic acid with
Joo Suk Oh, Jungtaek Park, Kiwook Kim, Hyun Ho Jeong, Young Min Oh, Semin Choi, Kyoung Ho Choi   +6 more
doaj   +1 more source

Incidence and associated factors of perioperative hypothermia in adult patients at a university-based, tertiary care hospital in Thailand

BMC Anesthesiology, 2023
Background Inadvertent perioperative hypothermia is an unintentional drop in core body temperature to less than 36 °C perioperatively and is associated with many negative outcomes such as infection, a prolonged stay in a recovery room, and decreased ...
Mingkwan Wongyingsinn, Varut Pookprayoon
doaj   +1 more source

Effects of local hypothermia-rewarming on physiology, metabolism and inflammation of acutely injured human spinal cord. [PDF]

, 2020
In five patients with acute, severe thoracic traumatic spinal cord injuries (TSCIs), American spinal injuries association Impairment Scale (AIS) grades A-C, we induced cord hypothermia (33 °C) then rewarming (37 °C).
A Bricolo, A Mizuma, A Schubert, C Hochstim, DW Marion, GL Clifton, GV Varsos, HA Choi, I Phang, I Phang, JR Bethea, K Chatzipanteli, K Chatzipanteli, KL Carpenter, L Zhu, M Dididze, M Erecinska, MC Werndle, MC Werndle, MJ Gallagher, PE Batchelor, PJ Andrews, PJ Hutchinson, RR Hansebout, S Chen, S Saadoun, S Shibuya, SR Lewis, TP Lo Jr.   +28 more
core   +1 more source

Short- and Long-Term Outcomes in Very Low Birth Weight Infants with Admission Hypothermia. [PDF]

PLoS ONE, 2015
Neonatal hypothermia remains a common problem and is related to elevated morbidities and mortality. However, the long-term neurodevelopmental effects of admission hypothermia are still unknown.
Hung-Yang Chang, Yi-Hsiang Sung, Shwu-Meei Wang, Hou-Ling Lung, Jui-Hsing Chang, Chyong-Hsin Hsu, Wai-Tim Jim, Ching-Hsiao Lee, Hsiao-Fang Hung   +8 more
doaj   +1 more source

Hypothermia-Mediated Apoptosis and Inflammation Contribute to Antioxidant and Immune Adaption in Freshwater Drum, Aplodinotus grunniens

Antioxidants, 2022
Hypothermia-exposure-induced oxidative stress dysregulates cell fate and perturbs cellular homeostasis and function, thereby disturbing fish health. To evaluate the impact of hypothermia on the freshwater drum (Aplodinotus grunniens), an 8-day experiment
Jianxiang Chen, Hongxia Li, Pao Xu, Yongkai Tang, Shenyan Su, Guangxiang Liu, Ningyuan Wu, Miaomiao Xue, Fan Yu, Wenrong Feng, Changyou Song, Haibo Wen   +11 more
doaj   +1 more source

Hypothermia and heart rate variability in a healthy newborn piglet model

Scientific Reports, 2022
Decreased heart rate variability (HRV) may be a biomarker of brain injury severity in neonatal hypoxic-ischemic encephalopathy for which therapeutic hypothermia is standard treatment. While therapeutic hypothermia may influence the degree of brain injury;
Mette Vestergård Pedersen, Ted Carl Kejlberg Andelius, Hannah Brogård Andersen, Kasper Jacobsen Kyng, Tine Brink Henriksen   +4 more
doaj   +1 more source