Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]
, 2019 Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix +5 more
core +1 more source
Intensive Care Medicine Experimental, 2022 Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation.
Denise Battaglini +12 more
doaj +1 more source
Acta Biomedica Scientifica, 2021 Background. Newborn infants who have undergone severe birth asphyxia have a high risk of neurological disorders and death. The most effective method for the treatment of hypoxic ischemic encephalopathy caused by intrapartum asphyxia is therapeutic ...
A. A. Zarubin +4 more
doaj +1 more source
Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial [PDF]
, 2015 Background Moderate cooling after birth asphyxia is associated with substantial reductions in death and disability, but additional therapies might provide further benefit.
Azzopardi, D +17 more
core +2 more sources
New architectural design of delivery room reduces morbidity in preterm neonates: a prospective cohort study [PDF]
, 2016 Background: A multidisciplinary committee composed of a panel of experts, including a member of the American Academy of Pediatrics and American Institute of Architects, has suggested that the delivery room (DR) and the neonatal intensive care units (NICU)
Aleandri, Vincenzo +7 more
core +1 more source
Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest : The PRINCESS Randomized Clinical Trial [PDF]
, 2019 © 2019 American Medical Association. All rights reserved.Importance: Therapeutic hypothermia may increase survival with good neurologic outcome after cardiac arrest.
Abella +43 more
core +3 more sources
Neuroprotection by Therapeutic Hypothermia
Frontiers in Neuroscience, 2019 Hypothermia therapy is an old and important method of neuroprotection. Until now, many neurological diseases such as stroke, traumatic brain injury, intracranial pressure elevation, subarachnoid hemorrhage, spinal cord injury, hepatic encephalopathy, and
Ying-Jian Sun +3 more
doaj +1 more source
Blood loss in primary total knee arthroplasty-body temperature is not a significant risk factor-a prospective, consecutive, observational cohort study [PDF]
, 2015 BACKGROUND: Hypothermia related to anaesthesia and operating theatre environment is associated with increased blood loss in a number of surgical disciplines, including total hip arthroplasty.
Beller, Elaine +5 more
core +2 more sources
Neuroprotective Role of Hypothermia in Acute Spinal Cord Injury
Biomedicines, 2022 Even nowadays, the question of whether hypothermia can genuinely be considered therapeutic care for patients with traumatic spinal cord injury (SCI) remains unanswered.
Hasan Al-Nashash, Angelo H. ALL
doaj +1 more source
Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling [PDF]
, 2009 Background: Mild therapeutic hypothermia following cardiac arrest is neuroprotective, but its effect on myocardial dysfunction that is a critical issue following resuscitation is not clear.
Albrecht, Martin +9 more
core +3 more sources