Results 41 to 50 of about 1,877,793 (121)

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

When Machine Perfusion Falls Short: Identifying Risks of Liver Graft Failure After Normothermic Machine Perfusion

Artificial Organs, Volume 50, Issue 10, Page 1407-1417, October 2026.
Analysis of 4928 normothermic machine perfusion liver transplants reveals that recipient factors, particularly MELD ≥ 35, surgical complexity, ICU status, and functional impairment are stronger predictors of graft failure than donor characteristics, emphasizing the continued importance of clinical judgment in patient selection.
Lauren E. Matevish, Abdullah K. Malik, Milana Harris, Ahmad Anouti, Taylor M. Coe, Simon Moosburner, Nathanael Raschzok, Arjmand Mufti, Parsia A. Vagefi, Madhukar S. Patel   +9 more
wiley   +1 more source

Real-Time Biomarkers of Liver Graft Quality in Hypothermic Oxygenated Machine Perfusion

Background: Hypothermic oxygenated machine perfusion has emerged as a strategy to alleviate ischemic-reperfusion injury in liver grafts. Nevertheless, there is limited data on the effectiveness of hypothermic liver perfusion in evaluating organ quality ...
Jan Borkowski, Marcin Morawski, Konrad Kobryń, Jan Stypułkowski, Benedykt Szczepankiewicz, Andriy Zhylko, Rafał Stankiewicz, Michał Grąt, Barbara Górnicka, Paweł Rykowski, Tadeusz Wróblewski, Marta Struga, Marek Krawczyk, Anya Wyporski, Maciej Krasnodębski, Wacław Hołówko, Waldemar Patkowski, Magdalena Mielczarek-Puta, Dmytro Zhylko   +18 more
core   +1 more source

Hypothermic oxygenated machine perfusion in porcine donation after circulatory determination of death liver transplant.

, 2012
BACKGROUND: Livers from donation after circulatory determination-of-death (DCD) donors suffer ischemic injury during a preextraction period of cardiac arrest and are infrequently used for transplantation; they have the potential, however, to considerably
Hessheimer, AJ, Garcia-Valdecasas, Juan C., Calatayud, David, Muñoz, J, Calatayud, D, Leuvenink, Henri, Fondevila, C, Rimola, A, Rimola, Antoni, Taura, Pilar, Leuvenink, Henri; id_orcid, García-Valdecasas, JC, Leuvenink, H, Ploeg, Rutger, Taurá, P, Hessheimer, Amelia J., Maathuis, MH, Fondevila, Constantino, Maathuis, Mark-Hugo J., Munoz, Javier, Ploeg, Rutger J.   +20 more
core   +1 more source

An Innovative Hyperbaric Hypothermic Machine Perfusion Protects the Liver from Experimental Preservation Injury [PDF]

, 2012
Purpose. Hypothermic machine perfusion systems seem more effective than the current static storage to prevent cold ischemic liver injury. Thus, we test an innovative hyperbaric hypothermic machine perfusion (HHMP), which combines hyperbaric oxygenation ...
BERNARDI, MAURO, Grattagliano I, DERENZINI, MASSIMO, Ferdinando A. Giannone, Caterina Maggioli, SGARBI, GIANLUCA, Pasquale Longobardi, Mauro Bernardi, Massimo Derenzini, TRERE', DAVIDE, MAGGIOLI, CATERINA, Longobardi P, Ignazio Grattagliano, GIANNONE, FERDINANDO, DOMENICALI, MARCO, Davide Treré, Marco Domenicali, Gianluca Sgarbi, Giancarlo Solaini, SOLAINI, GIANCARLO, CARACENI, PAOLO, Paolo Caraceni, BARACCA, ALESSANDRA, Alessandra Baracca   +23 more
core   +1 more source

Normothermic and hypothermic machine perfusion preservation versus static cold storage for deceased donor kidney transplantation

, 2015
\ua9 2015 The Cochrane Collaboration. This is the protocol for a review and there is no abstract. The objectives are as follows: This review aims to look at the benefits and harms of hypothermic or normothermic machine perfusion for the preservation of ...
Wilson CH, Figueiredo RS, Moir JAG, Talbot D   +3 more
core   +4 more sources

Hypothermic Machine Perfusion of Kidney Grafts: Which Pressure is Preferred?

, 2011
To assess the effect of the perfusion pressure (PP) during machine perfusion (MP) on the preservation quality of kidney grafts, we compared mean PPs of 25 and 30 mmHg using a porcine autotransplantation model.
Weis, J., Doorschodt, Benedict Marie, Schreinemachers, Marie-Claire Josette Michelle, Behbahani, Mehdi Johannes, Florquin, S., Doorschodt, B. M., Schreinemachers, M. C. J. M., Weis, Joachim, Behbahani, M., Tolba, René H., Florquin, Sandrine, Staat, M., Tolba, R. H.   +12 more
core   +1 more source

Limited Risk of Microbial Contamination During Hypothermic and Normothermic Machine Perfusion of Donor Kidneys [PDF]

Background: Both hypothermic machine perfusion (HMP) and normothermic machine perfusion (NMP) are increasingly used for preservation of deceased donor kidneys.
Minnee, Robert C., Reinders, Marlies E.J., Chong, Ga Lai M., Schurink, Carolina A.M., Slagter, Julia S., Porte, Robert J.   +5 more
core   +1 more source

Pancreas Preservation: Hypothermic Oxygenated Perfusion to Improve Graft Reperfusion

International audienceThe clinical standard for pancreas preservation for transplantation is static cold storage (SCS). Oxygenation during preservation has been shown to be advantageous in clinical studies.
Mesnard, Benoit, Branchereau, Julien, Cantarovich, Diego, Le Bas-Bernardet, Stéphanie, Ogbemudia, Etohan, Hervouet, Jeremy, Friend, Peter, Rigaud, Jérôme, Minault, David, Masset, Christophe, Ploeg, Rutger, Kervella, Delphine, Blancho, Gilles, Hunter, James, Badet, Lionel, Bruneau, Sarah, Prudhomme, Thomas   +16 more
core   +1 more source

Hypothermic Machine Perfusion of Composite Tissues

, 2017
Organ perfusion systems have successfully been applied to solid organ preservation and subsequent transplantation. However, their use in limb preservation for Vascularized Composite Tissue Allotransplantation (VCA) has yet to be thoroughly investigated ...
Troutman Mr., Eric Christopher
core