Results 31 to 40 of about 1,877,793 (121)

Hypothermic machine perfusion in kidney transplantation

, 2016
Purpose of reviewThis article summarizes novel developments in hypothermic machine perfusion (HMP) as an organ preservation modality for kidneys recovered from deceased donors.Recent findingsHMP has undergone a renaissance in recent years.
Moers, Cyril; id_orcid, Kocabayoglu, Peri, De Deken, Julie, Moers, Cyril   +3 more
core   +1 more source

The Anti‐Inflammatory Effect of Normothermic Machine Perfused Human Kidneys on Monocyte‐Derived Dendritic Cells

Artificial Organs, EarlyView.
The immunogenicity of donor kidneys on NMP can be studied using monocyte‐derived dendritic cells. Incubation with perfusate showed an anti‐inflammatory dendritic cell phenotype and function that suggests the release of an anti‐inflammatory factor or factors during NMP. ABSTRACT Background The immunomodulatory activity of normothermic machine perfusion (
Laura W. D. Knijff, Asel S. Arykbaeva, Sandra W. van der Kooij, Dorottya K. de Vries, Mieke F. van Essen, Ian P. J. Alwayn, Henri G. D. Leuvenink, Rutger J. Ploeg, Cees van Kooten   +8 more
wiley   +1 more source

Combined Hypothermic and Normothermic Machine Perfusion Improves Functional Recovery of Extended Criteria Donor Livers [PDF]

, 2018
Hypothermic oxygenated perfusion (HOPE) and normothermic perfusion are seen as distinct techniques of ex situ machine perfusion of the liver. We aimed to demonstrate the feasibility of combining both techniques and whether it would improve functional ...
Darius F. Mirza, Afford, Simon C, Wallace, Lorraine, Hynek Mergental, Mirza, Darius F, Andrea Schlegel, Attard, Joseph, Laing, Richard W, Joseph Attard, Richard W. Laing, M. Thamara P. R. Perera, Simon C. Afford, Bhogal, Ricky H, Desley A. H. Neil, Smith, Amanda, Yuri L. Boteon, Stefan Hübscher, Neil, Desley A H, Hübscher, Stefan, Ricky H. Bhogal, Boteon, Yuri L, Perera, M Thamara P R, Mergental, Hynek, Amanda Smith, Schlegel, Andrea, Lorraine Wallace   +25 more
core   +1 more source

Donor heart ischemic time can be extended beyond 9 hours using hypothermic machine perfusion in sheep

, 2023
Background: The global shortage of donor hearts available for transplantation is a major problem for the treatment of end-stage heart failure. The ischemic time for donor hearts using traditional preservation by standard static cold storage (SCS) is ...
Passmore, Margaret R, Ainola, Carmen, Sato, Kei, Bartnikowski, Nicole, Heinsar, Silver, Chan, Jonathan, Bouquet, Mahe, See Hoe, Louise E, Wilson, Emily S, Li Bassi, Gianluigi, Wildi, Karin, Skeggs, Kris, Hyslop, Kieran, Obonyo, Nchafatso G, Fraser, John F, et al.   +15 more
core   +1 more source

Heart Donation After Controlled Circulatory Death in Noncardiac Surgery Hospitals With a Mobile Heart Team: A Case Series From an Italian Regional Program and Integrated Review of the Literature

Artificial Organs, EarlyView.
In this series of 19 DCD donors using TA‐NRP, 89.5% of hearts were successfully transplanted with no PGD, no postoperative ECMO, and no 30‐day mortality, demonstrating the feasibility and safety of this approach. ABSTRACT Controlled donation after circulatory death (cDCD) with thoracoabdominal normothermic regional perfusion (TA‐NRP) has emerged ...
Maria Benedetto, Valentina Roncarati, Arianna Campana, Erika Cordella, Domenico Nocera, Sofia Martin‐Suarez, Luca Botta, Davide Pacini, Letizia Perinati, Massimo Baiocchi, Tommaso Tonetti, Fabrizio Monaco   +11 more
wiley   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

From the lethal triad to the lethal diamond and beyond: An AI‐augmented perspective on modern hemostatic resuscitation

Hong Kong Journal of Emergency Medicine, Volume 33, Issue 5, October 2026.
Abstract Background Uncontrolled hemorrhage remains the leading cause of preventable mortality in both civilian and military trauma sectors. The paradigm of resuscitation has decisively shifted from aggressive crystalloid administration to Damage Control Resuscitation, centering on early hemostatic control and the mitigation of the “Lethal Diamond ...
Jonghee Han, Junepill Seok, Su Young Yoon, Jin‐Uk Choi, Jin Suk Lee, Younghoon Sul   +5 more
wiley   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

A Multidisciplinary Approach to the Anesthetic Management of Patients With Duchenne Muscular Dystrophy

Pediatric Pulmonology, Volume 61, Issue 10, October 2026.
ABSTRACT Duchenne muscular dystrophy (DMD) is an inherited neuromuscular disorder with multisystem involvement that causes progressive muscular weakness and cardiorespiratory dysfunction. The first comprehensive recommendations regarding anesthetic management are now almost 20 years old and, in the interval, DMD care has evolved.
Fabrizio Racca, Elena Conti, Giulia Racca, Luigi Barberis, David J. Birnkrant   +4 more
wiley   +1 more source

Hypothermic Machine Perfusion Preservation of the DCD Kidney: Machine Effects

, 2020
properly cited. Purpose. Kidneys from DCD donors represent a significant pool, but preservation problems exist. The study objective was to test the importance of machine type for hypothermic preservation of DCD kidneys. Methods.
Martin J Mangino, John Brassil, Heather Muir, Susanne L Lindell   +3 more
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