Results 31 to 40 of about 1,864 (192)
European Journal of Medical Research, 2022 Background Serum uric acid (SUA) acts as an antioxidant and abnormally low SUA may raise the risk of developing atherosclerotic disorders. There is a U-shaped association between SUA with cardiovascular diseases (CVDs) in general population. However, the
Yao-Wei Zou +11 more
doaj +1 more source
Modulation of Urate Transport by Drugs
Pharmaceutics, 2021 Background: Serum urate (SU) levels in primates are extraordinarily high among mammals. Urate is a Janus-faced molecule that acts physiologically as a protective antioxidant but provokes inflammation and gout when it precipitates at high concentrations ...
Péter Tátrai +3 more
doaj +1 more source
Impact of Hyper- and Hypo-Uricemia on Kidney Function
Biomedicines, 2023 Uric acid (UA) forms monosodium urate (MSU) crystals to exert proinflammatory actions, thus causing gout arthritis, urolithiasis, kidney disease, and cardiovascular disease. UA is also one of the most potent antioxidants that suppresses oxidative stress.
Junichiro Miake +7 more
doaj +1 more source
Prevalence and possible causes of hypouricemia at a tertiary care hospital [PDF]
, 2016 Background/Aims: We aimed to investigate the prevalence and possible causes of hypouricemia in the Korean population and to compare our findings with published results of other populations.
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core +1 more source
Renal Tubular Hypouricemia and Calcium Urolithiasis [PDF]
, 1992 The information concerning the relationship of hypouricemia with urinary tract stones is limited. We investigated the incidence and types of hypouricemia, and also studied its relationship to urinary tract stones.
Kotake, Tadashi +2 more
core +1 more source
IJU Case Reports, 2023 Introduction Early diagnosis of patients with urolithiasis or hypouricemia owing to inborn errors of hypoxanthine metabolism is important in preventing renal failure or drug‐induced toxicity.
Tomiko Kuhara +7 more
doaj +1 more source
Molecular Genetics & Genomic Medicine, 2019 Background To identify potential causative mutations in SLC2A9 and SLC22A12 that lead to hypouricemia or hyperuricemia (HUA). Methods Targeted resequencing of whole exon regions of SLC2A9 and SLC22A12 was performed in three cohorts of 31 hypouricemia ...
Zhaowei Zhou +14 more
doaj +1 more source
Altered Serum Uric Acid Levels in Kidney Disorders
Life, 2022 Serum uric acid levels are altered by kidney disorders because the kidneys play a dominant role in uric acid excretion. Here, major kidney disorders which accompany hyperuricemia or hypouricemia, including their pathophysiology, are discussed.
Gheun-Ho Kim, Jae-Bum Jun
doaj +1 more source
Renal Replacement Therapy, 2020 Background/aims Familial juvenile hereditary nephropathy (FJHN) is characterized by hyperuricemia due to severely impaired urinary excretion of urate. Hereditary renal hypouricemia is an inborn error of membrane transport.
Fateme Shamekhi Amiri, Zohreh Rostami
doaj +1 more source
Benzofuran‐Based Uricosuric Agents: History, Roles, and Challenges
ChemistrySelect, Volume 11, Issue 24, 25 June 2026.Benzofuran‐based uricosuric agents represent a privileged medicinal chemistry scaffold for gout therapy. Structural optimization of benzbromarone‐related derivatives has improved hURAT1 inhibitory potency, metabolic stability, and urate‐lowering efficacy, while reducing hepatotoxic liability.
Raed M. Al‐Zoubi +7 more
wiley +1 more source