Results 221 to 230 of about 17,899 (259)

Differential Distortion of Purine Substrates by Human and Plasmodium falciparum Hypoxanthine-Guanine Phosphoribosyltransferase to Catalyse the Formation of Mononucleotides.

ChemPhysChem, 2015
Plasmodium falciparum (Pf) hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is a potential therapeutic target. Compared to structurally homologous human enzymes, it has expanded substrate specificity.
Vishakha Karnawat, S. Gogia, H. Balaram, Mrinalini Puranik   +3 more
semanticscholar   +1 more source

Hypoxanthine: Guanine phosphoribosyltransferase mutants in Saccharomyces cerevisiae

Molecular and General Genetics MGG, 1983
Yeast mutants lacking activity of the enzyme hypoxanthine:guanine phosphoribosyltransferase (H:G-PRT) have been isolated by selecting for resistance to 8-azaguanine in a strain carrying the wild type allele, ade4%, of the gene coding for amidophosphoribosyltransferase (PRPPAT), the first enzyme of de novo purine synthesis.
Darlene G. Roberts, Robin A. Woods, Theodore Friedman, David Filpula, Douglas J. Jolly   +4 more
openaire   +2 more sources

A rapid radiochemical assay for hypoxanthine-guanine phosphoribosyltransferase

Analytical Biochemistry, 1973
Abstract A simple radiochemical method is described for assay of hypoxanthine-guanine phosphoribosyltransferase. 14C-Hypoxanthine is incubated with enzyme PRPP. The labelled product is precipitated on strips of Whatman No. 1 paper by the addition of lanthanum nitrate. Unreacted substrate is eluted with distilled water.
Vincent P. Hollander, Michael A. Schlossberg   +1 more
openaire   +3 more sources

The Spectrum of Hypoxanthine-Guanine Phosphoribosyltransferase (HPRT) Deficiency

2006
Summary The enzyme hypoxanthine-guanine phosphoribo-syltransferase (HPRT) catalyzes the reutilization ofhypoxanthine and guanine to the purine nucleotidesIMP and GMP, respectively. HPRT deficiency is an X-linked disorder characterized by uric acid over-production and variable neurologic impairment.
Rosa J. Torres, Felícitas A. Mateos, Teresa H. Ramos, Antonio Buño, Juan G. Puig, Joaquín Arcas   +5 more
openaire   +3 more sources

Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.

Journal of Medicinal Chemistry, 2017
Acyclic nucleoside bisphosphonates (ANbPs) have previously been shown to be good inhibitors of human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Plasmodium falciparum (Pf) hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT).
P. Spacek, D. Keough, M. Chavchich, M. Dračínský, Z. Janeba, L. Naesens, M. Edstein, L. Guddat, D. Hocková   +8 more
semanticscholar   +1 more source

Mode of action of recombinant hypoxanthine–guanine phosphoribosyltransferase from Mycobacterium tuberculosis

, 2015
Tuberculosis (TB) is the second most important cause of mortality worldwide due to a single infectious agent, Mycobacterium tuberculosis. A better understanding of the purine salvage pathway can unveil details of the biology of M. tuberculosis that might
Paulo C. Patta, Leonardo K. Martinelli, M. Rotta, B. L. Abbadi, D. Santos, L. A. Basso   +5 more
semanticscholar   +1 more source

Genetic Analysis of Human Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency

Enzyme, 1987
Hypoxanthine-guanine phosphoribosyltransferase (HPRT; IMP: pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) functions in the purine-metabolic salvage pathway. Two clinical syndromes are associated with a deficiency in HPRT enzyme activity. Virtually complete deficiency leads to the Lesch-Nyhan syndrome, whereas partial deficiency results in ...
Larry J. Silverman, William N. Kelley, Thomas D. Palella   +2 more
openaire   +2 more sources

Clinical correlations in partial hypoxanthine guanine phosphoribosyltransferase deficiency

Pediatric Neurology, 1986
Erythrocyte assays for hypoxanthine guanine phosphoribosyltransferase (HGPRT) activity performed on two male half-siblings with hyperuricemia, produced results consistent with classic Lesch-Nyhan syndrome. Due to the absence of neurologic abnormalities, cognitive deficits, or self-mutilation, HGPRT activity was measured by intact fibroblast assay which
Joseph H. Hersh, William L. Nyhan, Theodore Page, J. Edwin Seegmiller, Mary E. Hand, Bernard Weisskopf   +5 more
openaire   +3 more sources

Human and Mouse Hypoxanthine-Guanine Phosphoribosyltransferase: Dimers and Tetramers

Science, 1979
Human and mouse hypoxanthine-guanine phosphoribosyltransferase subunits combine to form an active heteropolymer. Dimers form the basic subunit structure of the enzymes, yet the dimers can readily associate to form tetramers. The equilibrium between dimers and tetramers is significantly influenced by the ionic strength of the enzyme solvent.
Gerald G. Johnson, Lorraine R. Eisenberg, Barbara R. Migeon   +2 more
openaire   +3 more sources

Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency [PDF]

New England Journal of Medicine, 1983
A DEFICIENCY in the enzyme hypoxanthineguanine phosphoribosyltransferase (HPRT) is associated with two clinical syndromes.
Jeffrey S. Flier, Mary Jean Moore, James M. Wilson, Anne B. Young, William N. Kelley   +4 more
openaire   +2 more sources