Results 221 to 230 of about 14,819 (239)

Human Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT): Purification and Properties

1974
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (E.C. 2.4.2.8.) catalyzes the formation of guanosine-5’-monophosphate and inosine-5’-monophosphate from 5’-phosphoribosyl-l-pyrophosphate (PPribose-P) and the purine bases guanine and hypoxanthine, respectively.
W J, Arnold, R V, Lamb, W N, Kelley
openaire   +2 more sources

Human and Mouse Hypoxanthine-Guanine Phosphoribosyltransferase: Dimers and Tetramers

Science, 1979
Human and mouse hypoxanthine-guanine phosphoribosyltransferase subunits combine to form an active heteropolymer. Dimers form the basic subunit structure of the enzymes, yet the dimers can readily associate to form tetramers. The equilibrium between dimers and tetramers is significantly influenced by the ionic strength of the enzyme solvent.
G G, Johnson, L R, Eisenberg, B R, Migeon   +2 more
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The Spectrum of Hypoxanthine-Guanine Phosphoribosyltransferase (HPRT) Deficiency

2006
Summary The enzyme hypoxanthine-guanine phosphoribo-syltransferase (HPRT) catalyzes the reutilization ofhypoxanthine and guanine to the purine nucleotidesIMP and GMP, respectively. HPRT deficiency is an X-linked disorder characterized by uric acid over-production and variable neurologic impairment.
J G, Puig, R J, Torres, F A, Mateos, T, Ramos, A S, Buno, J, Arcas   +5 more
openaire   +2 more sources

Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) Mutations in the Asian Population

Nucleosides, Nucleotides and Nucleic Acids, 2011
Mutation of hypoxanthine guanine phosphoribosyltransferase (HPRT) gives rise to Lesch-Nyhan syndrome, which is characterized by hyperuricemia, severe motor disability, and self-injurious behavior, or HPRT-related gout (Kelley-Seegmiller syndrome). The marked heterogeneity of HPRT deficiency is well known, with more than 300 mutations at the HPRT gene ...
Y, Yamada, N, Wakamatsu, A, Taniguchi, K, Kaneko, S, Fujimori   +4 more
openaire   +2 more sources

Hypoxanthine‐Guanine Phosphoribosyltransferase Activity in Normal and Leukaemic Lymphocytes

British Journal of Haematology, 1981
Summary. The levels of hypoxanthine‐guanine phosphoribosyltransferase (HGPRT) were determined in lymphocytes from normal people and patients with chronic lymphocytic leukaemia (CLL). The HGPRT level in the total lymphocyte population from patients with CLL was lower than that from normal subjects.
P, Rambotti, S, Davis
openaire   +2 more sources

Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Nucleotide Interconversion

1980
It is well established that human Hypoxanthine-Guanine Phospho-ribosyltransferase (HGPRT, EC 2.4.2.8) catalyzes the reactions: Open image in new window Open image in new ...
GIACOMELLO, Alessandro, SALERNO, Costantino   +1 more
openaire   +3 more sources

Properties of Erythrocyte Purine Phosphoribosyltransferases in Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency

1974
Partial deficiency of HGPRT, a salvage enzyme of purine metabolism, has been demonstrated to be the primary abnormality causing purine overproduction in a small proportion of patients with gout (1–4). The quantitative deviation in the activity of this enzyme has been shown by Kelley et al.
O, Sperling, P, Boer, A, De Vries
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Xanthine phosphoribosyltransferase in man: Relationship to hypoxanthine-guanine phosphoribosyltransferase

Biochemical and Biophysical Research Communications, 1967
W N, Kelley, F M, Rosenbloom, J F, Henderson, J E, Seegmiller   +3 more
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Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)

RCSB Protein Data Bank, 2012
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[Hypoxanthine-guanine phosphoribosyltransferase deficiency].

Ryoikibetsu shokogun shirizu, 1998
Y, Arai, N, Sakuragawa
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