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Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Nucleotide Interconversion
1980It is well established that human Hypoxanthine-Guanine Phospho-ribosyltransferase (HGPRT, EC 2.4.2.8) catalyzes the reactions: Open image in new window Open image in new ...
GIACOMELLO, Alessandro +1 more
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Hypoxanthine‐Guanine Phosphoribosyltransferase Activity in Normal and Leukaemic Lymphocytes
British Journal of Haematology, 1981Summary. The levels of hypoxanthine‐guanine phosphoribosyltransferase (HGPRT) were determined in lymphocytes from normal people and patients with chronic lymphocytic leukaemia (CLL). The HGPRT level in the total lymphocyte population from patients with CLL was lower than that from normal subjects.
Pietro Rambotti, Stephen Davis
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Molecular Genetics of Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency in Man
Archives of Internal Medicine, 1985Hypoxanthine - guanine phosphoribosyltransferase (HPRT) is a purine salvage enzyme that plays a key role in the regulation of purine metabolism in man. Interest in this X-linked enzyme stems, in part, from the existence of two clinical syndromes associated with deficiency of HPRT enzyme activity.
James M. Wilson, William N. Kelley
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Biochemistry, 2011
Enzymatic efficiency and structural discrimination of substrates from nonsubstrate analogues are attributed to the precise assembly of binding pockets. Many enzymes have the additional remarkable ability to recognize several substrates.
S. Gogia, H. Balaram, Mrinalini Puranik
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Enzymatic efficiency and structural discrimination of substrates from nonsubstrate analogues are attributed to the precise assembly of binding pockets. Many enzymes have the additional remarkable ability to recognize several substrates.
S. Gogia, H. Balaram, Mrinalini Puranik
semanticscholar +1 more source
Hypoxanthine-guanine phosphoribosyltransferase from beef brain: A trimer
Biochemical and Biophysical Research Communications, 1980Abstract Hypoxanthine-guanine phosphoribosyl isolated from beef brain was reacted with cross-linking reagents in order to establish the number of subunits that constitute the native protein. The results obtained from experiments with dimethyl-suberimidate and gluteraldehyde in the absence and in the presence of substrates all indicate that the native
Valerie A. Paulus, Allan L. Bieber
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A micro-assay method for hypoxanthine-guanine and adenine phosphoribosyltransferases
Analytical Biochemistry, 1976Abstract An improved micro-assay method for hypoxanthine-guanine and adenine phosphoribosyltransferases is described. The assay relies on the isolation of isotopically labeled end-products by electrophoresis on cellulose acetate membrane using an electrophoretic apparatus which is used commonly in clinical laboratories.
Harutoshi Kizaki, Tomomi Sakurada
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Genetic heterogeneity at the locus for hypoxanthine-guanine phosphoribosyltransferase.
Ciba Foundation symposium, 1977The purine phosphoribosyltransferases have emerged as important enzymes in the metabolic economy of the developing human. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT, EC 2.4.2.8) catalyses the conversion of hypoxanthine and guinine into their respective nucleotides.
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Hypoxanthine, Guanine, Xanthine Phosphoribosyltransferase Activity inCryptosporidium parvum
Experimental Parasitology, 1998All parasitic protozoa examined to date are incapable of de novo synthesis of purine nucleotides and rely on salvage mechanisms for survival. We have identified hypoxanthine, guanine, xanthine phosphoribosyl-transferase activities in crude cell-free extracts of Cryptosporidium sporulated oocysts utilizing radiolabeled substrates. Guanine, hypoxanthine,
Jamil Kanaani +2 more
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Steady-state kinetics of the schistosomal hypoxanthine-guanine phosphoribosyltransferase
Biochemistry, 1992Schistosomiasis is a trematode infection of some 200 million people. The hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) of the major etiologic agent, Schistosoma mansoni, has been proposed as a potential target for antischistosomal chemotherapy [Dovey, H. F., McKerrow, J. H., & Wang, C. C. (1984) Mol. Biochem. Parasitol, 11, 157-167].
Ling Yuan +3 more
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Postnatal Expression of Hypoxanthine Guanine Phosphoribosyltransferase in the Mouse Brain
Enzyme and Protein, 1993The distributional and activity changes of hypoxanthine guanine phosphoribosyltransferase (HGPRT) were investigated in the developing mouse brain. The HGPRT activity level was low at birth, increased rapidly during the first 7 days of life, and underwent a gradual increase thereafter to the mature level.
Shigeki Nakagawa +2 more
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