Results 51 to 60 of about 17,899 (259)

Targeting purine metabolism in ovarian cancer

Journal of Ovarian Research, 2022
Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jingchun Liu, Shasha Hong, Jiang Yang, Xiaoyi Zhang, Ying Wang, Haoyu Wang, Jiaxin Peng, Li Hong   +7 more
doaj   +1 more source

Purification and Characterization of Human Hypoxanthine/Guanine Phosphoribosyltransferase [PDF]

European Journal of Biochemistry, 1977
Human hypoxanthine/guanine phosphoribosyltransferase (EC 2.4.2.8) was purified from red blood cells by the following two methods. Method A includes (a) elimination of hemoglobin by DEAE‐cellulose, (b) DEAE‐Sephadex chromatography, (c) specific elution of the enzyme from CM‐Sephadex by pyrophosphate and (d) Sephadex G‐100 gel filtration.
Helmut Muensch, Akira Yoshida
openaire   +3 more sources

Mitochondrial metabolism of guanine nucleotides possible role of guanosine [PDF]

, 1989
The catabolism of intramitochondrial guanine nucleotides was examined. During 30 min incubation of rat liver mitochondria at 37°C in the presence of oligomycin and carboxyatractyloside, guanine and xanthine were formed and appeared in the medium.
Alexander M. Pimenov, Aprille, Bergmeyer, Bestwick, Dubiel, Gerhard Gerber, Mathias Ziegler, McKee, Park, Pimenov, Rusian T. Toguzov, Söling, Watkins, Wolfgang Dubiel, Wolfgang Henke, Yuri V. Tikhonov, Ziegler, Ziegler   +17 more
core   +1 more source

Proteomes of Lactobacillus delbrueckii subsp. bulgaricus LBB.B5 Incubated in Milk at Optimal and Low Temperatures. [PDF]

, 2017
We identified the proteins synthesized by Lactobacillus delbrueckii subsp. bulgaricus strain LBB.B5 in laboratory culture medium (MRS) at 37°C and milk at 37 and 4°C.
Angel Angelov, Brett S. Phinney, Korneel Rabaey, Maria L. Marco, Michelle R. Salemi, Velitchka Gotcheva, Xiaochen Yin   +6 more
core   +2 more sources

dGTP starvation in Escherichia coli provides new insights into the thymineless-death phenomenon.

PLoS Genetics, 2014
Starvation of cells for the DNA building block dTTP is strikingly lethal (thymineless death, TLD), and this effect is observed in all organisms. The phenomenon, discovered some 60 years ago, is widely used to kill cells in anticancer therapies, but many ...
Mark Itsko, Roel M Schaaper
doaj   +1 more source

Induced pluripotent stem cells from subjects with Lesch-Nyhan disease

Scientific Reports, 2021
Lesch-Nyhan disease (LND) is an inherited disorder caused by pathogenic variants in the HPRT1 gene, which encodes the purine recycling enzyme hypoxanthine–guanine phosphoribosyltransferase (HGprt).
Diane J. Sutcliffe, Ashok R. Dinasarapu, Jasper E. Visser, Joery den Hoed, Fatemeh Seifar, Piyush Joshi, Irene Ceballos-Picot, Tejas Sardar, Ellen J. Hess, Yan V. Sun, Zhexing Wen, Michael E. Zwick, H. A. Jinnah   +12 more
doaj   +1 more source

Reduced levels of dopamine and altered metabolism in brains of HPRT knock-out rats: a new rodent model of Lesch-Nyhan Disease [PDF]

, 2016
Lesch-Nyhan disease (LND) is a severe neurological disorder caused by loss-of-function mutations in the gene encoding hypoxanthine phosphoribosyltransferase (HPRT), an enzyme required for efficient recycling of purine nucleotides.
AM Geurts, C Tong, CL Wu, D Pelled, DJ Creek, DJ Williamson, E Zoref-Shani, GD Zheng, GH Guibinga, GH Guibinga, GR Breese, HA Jinnah, HA Jinnah, HA Jinnah, HA Simmonds, K Blair, KG Lloyd, M Buehr, M Hooper, M Lesch, M Mazzali, MA Cenci, MG Garcia, MK Dienhart, MR Kuehn, P Li, QL Ying, RJ Torres, S Brosh, S Finger, S Meek, S Meek, S Wolf, SB Dunnett, SL Meddle, SM Downs, SM Downs, TJ Aitman, TP Yang, TP Zwaka, WJ Tax, WL Nyhan, WL Nyhan, X Zheng, Y Chen, Y Yu   +45 more
core   +3 more sources

Encephalomalacia/gliosis, deep venous thrombosis, and cancer in Arg393His antithrombin Hanoi and the potential impact of the β-amyloid precursor protein (APP) on thrombosis and cancer

AIMS Neuroscience, 2022
A heterozygous Arg393His point mutation at the reactive site of antithrombin (AT) gene causing thrombosis in a Vietnamese patient is reported and named as Arg393His in AT-Hanoi.
Khue Vu Nguyen
doaj   +1 more source

Data in support of the mutagenic potential of the isoflavone irilone in cultured V79 cells

Data in Brief, 2015
The isoflavone irilone is found in human plasma after ingestion of red clover-based dietary supplements, but information allowing safety assessment is rare.
Anne Scheffler, Annette E. Albrecht, Harald L. Esch, Leane Lehmann   +3 more
doaj   +1 more source

Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome [PDF]

, 2007
Deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity is an inborn error of purine metabolism associated with uric acid overproduction and a continuum spectrum of neurological manifestations depending on the degree of the enzymatic
A Edwards, B Aral, B Aral, B Bakay, BL Davidson, C Prior, C Rinat, C Rinat, CS Bavaresco, CS Pinto, CS Pinto, D Hoefnagel, D Pelled, DF Wong, DJ Jolly, DJ Schretlen, DW Smith, E Dabrowski, E Pralong, E Zoref-Shani, FM Rosenbloom, FS Silverstein, GR Breese, GW Graham, H Criswell, HA Jinnah, HA Jinnah, HA Jinnah, HA Jinnah, HA Jinnah, HJ Rylance, J García Puig, J Jankovic, J McManaman, JC Crawhall, JC Harris, JE Seegmiller, JE Visser, JG Puig, JG Puig, JM Kaufman, JM Wilson, JP O'Neill, Juan G Puig, K Hara, KG LLoyd, L De Gregorio, L De Gregorio, L De Gregorio, L De Gregorio, L Olson, L Olson, LT Anderson, LT Anderson, M Bertelli, M Ernst, M Hakoda, M Lesch, MA Becker, N Ogasawara, P van Bogaert, R Christie, RA Gibbs, RJ Torres, RJ Torres, RJ Torres, RJ Torres, RO McKeran, RO McKeran, Rosa J Torres, RW Rundles, RW Watts, SJ Engle, SP van der Zee, SR Schroeder, T Page, T Taira, T Yukawa, TL Shirley, VK Neychev, W Catel, WA Brock, WL Nyhan, WL Nyhan, WN Kelley, WN Kelley, WN Kelley, WS Matthews   +87 more
core   +2 more sources