Results 81 to 90 of about 13,983 (221)

Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes [PDF]

, 2011
Context: Increased plasma levels of glucose-dependent insulinotropic polypeptide (GIP), calcitonin CT gene-related peptide (CGRP)-I, and procalcitonin (Pro-CT) are associated with obesity.
Christ-Crain, Mirjam, Dembinski, Kaethi, Frey, Daniel M., Grisouard, Jean, Häring, Andreas, Keller, Ulrich, Müller, Beat, Peterli, Ralph, Radimerski, Tanja, Timper, Katharina, Zulewski, Henryk   +10 more
core   +1 more source

Mitigating Dexamethasone‐Induced Muscle Wasting and Mitochondrial Impairment in Mice on a High‐Fat and High‐Sucrose Diet With Peanut Sprout Extract

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Peanut sprout extract (PSE) significantly attenuated skeletal muscle atrophy induced by a high‐fat, high‐sucrose diet and dexamethasone, improving muscle strength and reducing triglyceride accumulation and inflammation. It enhanced mitochondrial function by upregulating TFAM and OXPHOS proteins and partially restoring PGC1α expression.
Sang‐Mi Jo, Thi My Tien Truong, Hyun‐Jin Jang, Ji Hee Lim, Inhae Kang   +4 more
wiley   +1 more source

Data supporting the design and evaluation of a universal primer pair for pseudogene-free amplification of HPRT1 in real-time PCR

Data in Brief, 2015
Hypoxanthine-guanine phosphoribosyltransferase 1 (HPRT1) is a common housekeeping gene for sample normalization in the quantitative reverse transcriptase polymerase chain (qRT-PCR).
Reza Valadan, Akbar Hedayatizadeh-Omran, Mahdyieh Naghavi Alhosseini-Abyazani, Omolbanin Amjadi, Alireza Rafiei, Mohsen Tehrani, Reza Alizadeh-Navaei   +6 more
doaj   +1 more source

Vitamin D and calcium metabolism in horses in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Veterinary Science at Institute of Veterinary, Animal and Biomedical Sciences (IVABS), Massey University, Manawatū, New Zealand [PDF]

, 2016
The physiology of vitamin D in horses has not been studied in great depth. Few studies on vitamin D metabolites (25OHD2, 25OHD3, and 1,25(OH)2D) and their relationship to other serum analytes exist. In addition, some studies suggest that equine vitamin D
Azarpeykan, Sara
core  

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +3 more sources

Gene Expression, Docking and Machine Learning in Malaria Drug Discovery: A Systematic Review

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Background Malaria remains a significant and worldwide health threat with increasing resistance to current treatments, stimulating the demand for innovative approaches in pursuing drug discovery. This systematic review integrates the progress made from 2014 through 2024 regarding molecular methods like gene expression profiling, molecular docking and ...
Reuben Samson Dangana, Israel Ehizuelen Ebhohimen, Samson Anjikwi Malgwi, Samuel Chima Ugbaja, Moses Okpeku, Harleen Khatra   +5 more
wiley   +1 more source

Epiafzelechin, a Flavanol, Regulates Lipid Homeostasis Through Modulation of HMGCR, PCSK9, and PPAR‐α: Mechanistic Insights and Therapeutic Implications

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Hyperlipidemia remains a leading modifiable risk factor for cardiovascular morbidity and mortality. Statins are considered the cornerstone of treatment; however, their adverse effects and limited efficacy in certain patient populations necessitate exploration of novel therapeutic avenues. Epiafzelechin (EZN), a flavanol with established antioxidant and
Saud O. Alshammari, Nazifa Shahzad, Muhammad Nasir Hayat Malik, Qamar A. Alshammari, Abdulkarim Alshammari, Bassam S. M. Al Kazman, Muhammad Atif, Gideon F. B. Solre, Vivek Pandey   +8 more
wiley   +1 more source

Immunization with purine salvation pathway recombinant enzymes induces the production of anti- Schistosoma mansoni immunoglobulines [PDF]

Schistosomiasis, a disease caused by the trematodes of the Schistosoma genus, affects about 240 million people worldwide. The Praziquantel (PZQ) is the drug used to treat this disease. However, reports of resistant strains reinforce the need to develop a
Adachi, Felipe de Pontes, Anibal, Fernanda de Freitas, Correia, Ricardo de Oliveira, Dejani, Naiara Naiana, Garratt, Richard Charles, Neris, Débora Meira, Oliveira, Sandra Regina Pereira de, Pereira, Humberto D'Muniz, Rodolpho, Joice Margareth de Almeida, Rodrigues, Vanderlei, Souza, Laís Cristina de   +10 more
core  

Sh3bp2 Gain-Of-Function Mutation Ameliorates Lupus Phenotypes in B6.MRL-Faslpr Mice [PDF]

, 2019
SH3 domain-binding protein 2 (SH3BP2) is an adaptor protein that is predominantly expressed in immune cells, and it regulates intracellular signaling. We had previously reported that a gain-of-function mutation in SH3BP2 exacerbates inflammation and bone
Iseki, Masanori, Ishihara, Katsuhiko, Kashihara, Naoki, Kawahara, Kyoko, Morita, Yoshitaka, Mukai, Tomoyuki, Nagasu, Akiko, Nagasu, Hajime, Tsuji, Shoko, Ueki, Yasuyoshi   +9 more
core   +1 more source

Interference of Sulphonate Buffering Agents with E. coli Hypoxanthine-Guanine Phosphoribosyltransferase Active Site Functioning: A Crystallographic and Enzymological Study

Crystals
The investigation of the structure–function relationship in hypoxanthine-guanine phosphoribosyltransferases (HGPRT) is a direction that is relevant for the development of drugs and approaches of enzymatic synthesis of modified nucleosides and nucleotides.
Evgeniy A. Zayats, Yulia A. Abramchik, Maria A. Kostromina, Vladimir I. Timofeev, Mikhail B. Shevtsov, Alexey V. Mishin, Ilya V. Fateev, Andrey A. Karanov, Alexandra R. Sharafutdinova, Aleksandra O. Arnautova, Irina D. Konstantinova, Valentin I. Borshchevskiy, Roman S. Esipov   +12 more
doaj   +1 more source