Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells [PDF]
, 2017 Melittin, the main peptide present in bee venom, has been proposed as having potential for anticancer therapy; the addition of melittin to cisplatin, a first line treatment for ovarian cancer, may increase the therapeutic response in cancer treatment via
Alonezi, Sanad +10 more
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Physiological Reports, Volume 13, Issue 24, December 2025.Aging contributes to impairments in pulmonary microvascular endothelial cell‐cell junctions and barrier function, leading to an increased predisposition to injury. Created in BioRender. Gill, S. (2025) https://BioRender.com/l14r5v8 Abstract Pulmonary microvascular endothelial cell (PMVEC) intercellular junctions are critical for maintaining barrier ...
Aminmohamed Manji +10 more
wiley +1 more source
Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila
eLifeAdenine phosphoribosyltransferase (APRT) and hypoxanthine-guanine phosphoribosyltransferase (HGPRT) are two structurally related enzymes involved in purine recycling in humans.
Céline Petitgas +11 more
doaj +1 more source
Signalling Mechanisms Underlying Doxorubicin and Nox2 NADPH Oxidase-Induced Cardiomyopathy: Involvement of Mitofusin-2 [PDF]
, 2017 BACKGROUND AND PURPOSE: The anthracycline doxorubicin (DOX), although successful as a first-line cancer treatment, induces cardiotoxicity linked with increased production of myocardial reactive oxygen species (ROS), with Nox2 NADPH oxidase-derived ...
Dunne, Philip D +7 more
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JIMD Reports, 2020 Background Lesch‐Nyhan disease (LND; OMIM 300322), caused by virtually absent hypoxanthine‐guanine phosphoribosyltransferase activity, in its classic form is characterised by hyperuricemia, variable cognitive impairment, severe motor disorder and a ...
Anna Bozano +6 more
doaj +1 more source
5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications [PDF]
, 2013 Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region ...
Dobolyi, Árpád +3 more
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Induction of Mineralization [PDF]
, 2014 Vascular mineralization contributes to the high cardiovascular morbidity and mortality in patients who suffer from chronic kidney disease and in individuals who have undergone solid organ transplantation. The immunosuppressive regimen used to treat these
Giet, Markus van der +6 more
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Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes [PDF]
, 2012 Peer reviewedPublisher ...
Agouni, Abdelali +3 more
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The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: MiR-21 and promoter methylation [PDF]
, 2016 Background: PTEN is a tumor suppressor gene which is involved in cellular proliferation, differentiation, and apoptosis. Loss or down-regulation of PTEN plays an important role in human cancers development.
Azadeh, H. +3 more
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