Results 111 to 120 of about 503 (139)
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Pediatrics, 1991
The study by Rognum and Saugstad concerning elevated hypoxanthine levels in the vitreous humor of victims of Sudden Infant Death Syndrome (SIDS) made a laudable attempt to correct for postmortem increases in this marker of hypoxia, but I am concerned that the authors have not sufficiently recognized some characteristics of SIDS that could have ...
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The study by Rognum and Saugstad concerning elevated hypoxanthine levels in the vitreous humor of victims of Sudden Infant Death Syndrome (SIDS) made a laudable attempt to correct for postmortem increases in this marker of hypoxia, but I am concerned that the authors have not sufficiently recognized some characteristics of SIDS that could have ...
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Experimental Cell Research, 1977
Summary Transport of purine bases and nucleosides by a variety of mammalian cell lines is generally accomplished by facilitated diffusion, a non-concentrative, saturable process. However, previous investigators have been unable to detect a saturable component for the transport of hypoxanthine by human fibroblasts deficient in hypoxanthine-guanine ...
E, Murphy, M J, Holland, R P, Cox
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Summary Transport of purine bases and nucleosides by a variety of mammalian cell lines is generally accomplished by facilitated diffusion, a non-concentrative, saturable process. However, previous investigators have been unable to detect a saturable component for the transport of hypoxanthine by human fibroblasts deficient in hypoxanthine-guanine ...
E, Murphy, M J, Holland, R P, Cox
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Experimental Cell Research, 1977
Abstract We have examined the possible relation between hypoxanthine guanine phosphoribosyltransferase (EC 2.4.2.7., HGPRT) activity and hypoxanthine transport in the normal human lymphoblast line MGL8 and two HGPRT- mutant lines derived from it. The mutant line MGL8A29 (L8A29) had considerable amounts of material cross-reacting immunologically to ...
J, Epstein, J W, Littlefield
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Abstract We have examined the possible relation between hypoxanthine guanine phosphoribosyltransferase (EC 2.4.2.7., HGPRT) activity and hypoxanthine transport in the normal human lymphoblast line MGL8 and two HGPRT- mutant lines derived from it. The mutant line MGL8A29 (L8A29) had considerable amounts of material cross-reacting immunologically to ...
J, Epstein, J W, Littlefield
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Hypoxanthine-guanine phosphoribosyl transferase deficiency
Human Genetics, 1976In man congential lack of enzyme of the purine salvage system, hypoxanthineguanine phosphoribosyl transferase (HG-PRT E.C. 2.4.2.8), is mostly accompanied by a picture known as the Lesch-Nyhan snydrome. The degree of deficiency may vary from zero to a few percent of normal activity but a correlation between the severity of HG-PRT deficiency and the ...
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Electrochemical oxidation of hypoxanthine
Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1981Abstract The electrochemical oxidation of hypoxanthine (6-oxypurine) in aqueous solution has been studied. The evidence strongly supports the view that hypoxanthine is initially electrooxidized in a 2 e −2H + reaction to give 6,8-dioxypurine. The latter compound is more easily oxidized than hypoxanthine and is immediately further electrooxidized to ...
Arnold C. Conway +2 more
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Hypoxanthine Transport Through Human Erythrocyte Membranes
1986It is well known that purine bases can be taken up and utilized by the cells in nucleotide synthesis (1). In bacterial cells, purine bases from external medium are phosphoribosylated and transported through the plasma membrane in one step catalyzed by phosphoribosyltransferases which are located in the pericytoplasmic compartment (2).
CAPUOZZO, Elisabetta +3 more
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Hypoxanthine transport in human erythrocytes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1967Abstract Using rapid sampling by filtration, it has been possible to follow and describe the transport of hypoxanthine across the human red blood cell membrane. The dependence of the transport rate upon the concentration of hypoxanthine is complex, and suggests a two-component mechanism. The first is a “saturable carrier system” with a K m of 0.
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Ribosyl derivatives of hypoxanthine
The Journal of Organic Chemistry, 1969J A, Montgomery, H J, Thomas
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