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Plasma Hypoxanthine and Exercise
American Review of Respiratory Disease, 1987Abstract During exercise, ATP is converted to ADP and AMP to supply energy for muscular contraction. It is then regenerated via various pathways of intermediary metabolism. However, with high levels of exercise, net ATP degradation in muscle occurs.
L H, Ketai +3 more
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On the interaction of hypoxanthine with adenine
Experientia, 1967Une conversion non-enzymatique d'hypoxanthine en adenine fut proposee sur la base d'observations spectrophotometriques obtenues de solutions contenant adenine et hypoxanthine dans 1–5M de phosphate d'ammonium. Les resultats fournis par les experiences sur la radioactivite ne confirme pas la conclusion emise parBowne2 que hypoxanthine et adenine ...
J, Ludowieg, J D, Benmaman
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Hypoxanthine Phosphoribosyltransferase and Hypoxanthine Uptake in Human Erythrocytes
Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1975A system of hypoxanthine uptake and IMP retention was studied and characterized in human erythrocytes. It follows closely the system already described for rabbit erythrocytes[7]. IMP formation and retention are dependent on the activity of hypoxanthine phosphoribosyl-transferase and on intracellular availability of phosphoribosyl pyrophosphate (P-Rib ...
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Biochemical Medicine, 1973
Abstract Hypoxanthine transport has been studied in cultured human fibroblasts with normal and mutant H-G PRT. Transport is dependent on cell density, the activity of H-G PRT, and de novo purine synthesis. Transport is decreased in control cultures at high density and in cell strains with a mutant H-G PRT.
P J, Benke, N, Herrick, A, Herbert
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Abstract Hypoxanthine transport has been studied in cultured human fibroblasts with normal and mutant H-G PRT. Transport is dependent on cell density, the activity of H-G PRT, and de novo purine synthesis. Transport is decreased in control cultures at high density and in cell strains with a mutant H-G PRT.
P J, Benke, N, Herrick, A, Herbert
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Facilitated Purification of Hypoxanthine Phosphoribosyltransferase
Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1976Three major approaches to the complete purification of hypoxanthine phosphoribosyltransferase from human erythrocytes and rat brain are described. Preparative isoelectric focusing which has been used for the isolation of the human enzyme was not fully successful in the case of rat brain.
W, Gutensohn, M, Huber, H, Jahn
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New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity.
American Journal of Physiology. Endocrinology and Metabolism, 2020Xanthine oxidoreductase (XOR) consists of two different forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), and is a rate-limiting enzyme of uric acid production from hypoxanthine and xanthine. Uric acid is the end-product of purine metabolism
M. Furuhashi
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Hypoxanthine in cerebrospinal fluid in children
Scandinavian Journal of Clinical and Laboratory Investigation, 1978In forty-five children the hypoxanthine concentration in cerebrospinal fluid (CSF) was measured (fifty-two samples). In newborn infants (nineteen patients) the hypoxanthine levels were higher in patients with clinical conditions associated with hypoxia (idiopathic respiratory distress syndrome, asphyxia, apneic attacks) than in patients without ...
A, Meberg, O D, Saugstad
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Hypoxanthine Transport in Human Erythrocytes
1980De novo synthesis of purines does not appear to take place in mature human erythrocytes because the enzymes for the pathway are absent1. Therefore purine bases should be normally have to be supplied exogenously to erythrocytes.
GIACOMELLO, Alessandro +1 more
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Pediatrics, 1991
The study by Rognum and Saugstad concerning elevated hypoxanthine levels in the vitreous humor of victims of Sudden Infant Death Syndrome (SIDS) made a laudable attempt to correct for postmortem increases in this marker of hypoxia, but I am concerned that the authors have not sufficiently recognized some characteristics of SIDS that could have ...
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The study by Rognum and Saugstad concerning elevated hypoxanthine levels in the vitreous humor of victims of Sudden Infant Death Syndrome (SIDS) made a laudable attempt to correct for postmortem increases in this marker of hypoxia, but I am concerned that the authors have not sufficiently recognized some characteristics of SIDS that could have ...
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