Analysis of prescription pattern of antihypertensives in various stages of chronic kidney disease [PDF]
, 2019 Background: Chronic kidney disease (CKD) is an emerging health problem and is one of the major causes of mortality. Hypertension is closely linked with CKD and both these conditions cause severe cardiovascular events.
Jayakumar, K. P. +2 more
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Preparation of 9-substituted pyridine-stretched adenines and hypoxanthines [PDF]
, 2009 9-Methylsulfanyl pyridine-stretched adenine and hypoxanthine derivatives have been prepared via regioselective reaction of a 5-aminoimidazole with 2-(bis-methylsulfanylmethylene)malononitrile [(NC)C=C(SMe) ].
Crawford, Julia A. +2 more
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THE ESTIMATION OF HYPOXANTHINE [PDF]
Journal of Biological Chemistry, 1942 In a previous paper there was described a procedure for the isolation of the purines in a form suitable for the quantitative determination of the individual substances (1). A later publication reported a method for the separation of adenine and hypoxanthine and the determination of the adenine by precipitation of adenine picrate and titration of the ...
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The role of physical activity in individuals with cardiovascular risk factors: an opinion paper from Italian Society of Cardiology-Emilia Romagna-Marche and SIC-Sport [PDF]
, 2019 : Regular physical activity is a cornerstone in the prevention and treatment of atherosclerotic cardiovascular disease (CVD) due to its positive effects in reducing several cardiovascular risk factors. Current guidelines on CVD suggest for healthy adults
Berrettini, Umberto +16 more
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Nucleophile-Catalyzed Additions to Activated Triple Bonds. Protection of Lactams, Imides, and Nucleosides with MocVinyl and Related Groups [PDF]
, 2014 Additions of lactams, imides, (S)-4-benzyl-1,3-oxazolidin-2-one, 2-pyridone, pyrimidine-2,4-diones (AZT derivatives), or inosines to the electron-deficient triple bonds of methyl propynoate, tert-butyl propynoate, 3-butyn-2-one, N-propynoylmorpholine, or
Adler M. +71 more
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Metabolomes and lipidomes of the infective stages of the gastrointestinal nematodes, Nippostrongylus brasiliensis and Trichuris muris [PDF]
, 2020 Soil-transmitted helminths, including hookworms and whipworms, infect billions of people worldwide. Their capacity to penetrate and migrate through their hosts’ tissues is influenced by the suite of molecules produced by the infective developmental ...
Anderson, Dovile +6 more
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Angewandte Chemie, EarlyView.AZD0156, an ATM kinase inhibitor in clinical development, shows promising multistage antiplasmodial activity by targeting Plasmodium falciparum phosphatidylinositol 4‐kinase (PfPI4Kβ). With an improved specificity profile relative to other PfPI4Kβ inhibitors and moderate efficacy in a P.
John G. Woodland +33 more
wiley +2 more sources
Hypoxanthine as a Measurement of Hypoxia [PDF]
Pediatric Research, 1975 The hypoxanthine concentration in plasma was found to be a sensitive parameter of hypoxia of the fetus and the newborn infant. The plasma level of hypoxanthine in the umbilical cord in 29 newborn infants with normal delivery varied between 0 and 11.0 mumol/liter with a mean of 5.8 mumol/liter, SD 3.0 mumol/liter.
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Intracellular acidosis: Can it delay the inevitable? [PDF]
, 1990 The relationships between extracellular pH (pH o ), intracellular pH (pH i ), and loss of cell viability were evaluated in cultured rat hepatocytes after ATP depletion by metabolic inhibition with KCN and iodoacetate (chemical hypoxia).
Moseley, Richard H.
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Multi-Omics to Illuminate Signaling Molecules of the Gut Microbiota-Brain Axis [PDF]
, 2021 The human gastrointestinal (GI) tract harbors hundreds of trillions of microorganisms, collectively referred to as the gut microbiota. Complex, dynamic, and metabolically active by nature, these commensal microbes carry critical functional roles in ...
Lai, Yunjia
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