Results 161 to 170 of about 56,007 (232)

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Astragalus polysaccharide attenuates retinal ischemia reperfusion-induced microglial activation through sortilin-related vacuolar protein sorting 10 domain containing receptor 2/laminin subunit alpha 1 upregulation.

Cytojournal
Li J, Li H, Wei C, Chen C, Zheng Z.
europepmc   +1 more source

Ephedrine Attenuates LPS-Induced Acute Lung Injury in Mice by Inhibiting OTUB1 and Promoting K48 Ubiquitination of HIF1α. [PDF]

J Cell Mol Med
Zhou B, Zhao K, Xue J, Zhou F, Duan JA, Niu Y, Wang H.   +6 more
europepmc   +1 more source

The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks [PDF]

, 2017
Ivan, Mircea, Kaelin, William G., Jr.
core   +1 more source

Obesity‐Induced Metabolic Priming Exacerbates SARS‐CoV‐2 Inflammation

Immunology, Volume 175, Issue 3, Page 323-338, July 2025.
Monocytes primed under obesogenic conditions, such as increased FFA levels (i.e., palmitate) exhibit exacerbated gene expression of inflammatory cytokines. The increased proinflammatory response of palmitate‐primed and SARS‐CoV‐2‐infected monocytes is not dependent on glycolytic metabolism but instead on the entry of FFAs into the mitochondria ...
Gustavo Gastão Davanzo, Bianca Gazieri Castelucci, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, Larissa Menezes dos Reis, Isabella Bonilha de Oliveira, José Luís Fachi, João Victor Virgilio‐da‐Silva, Marcelo Rodrigues Berçot, Mariane Font Fernandes, Sarah de Oliveira, Nathalia Vitoria Pereira Araujo, Guilherme Ribeiro, Gisele de Castro, Webster Leonardo Guimarães Costa, Adriana Leandra Santoro, Gabriela Flavia Rodrigues‐Luiz, Helison Rafael P. do Carmo, Ikaro Breder, Marcelo A. Mori, Alessandro S. Farias, Daniel Martins‐de‐Souza, Joseph W. Guarnieri, Douglas C. Wallace, Marco Aurélio Ramirez Vinolo, José Luiz Proença‐Módena, Afshin Beheshti, Andrei C. Sposito, Pedro M. Moraes‐Vieira   +28 more
wiley   +1 more source

Remifentanil Ameliorates Lipopolysaccharide-Induced Neuroinflammation by Regulating the Phosphatidylinositol 3-Kinase/Serine-Threonine Protein Kinase/Hypoxia-Inducible Factor 1 Alpha Pathway. [PDF]

Pharmacol Res Perspect
Özcan MS, Aşcı H, Karabacak P, Özden ES, İmeci OB, Özmen Ö.   +5 more
europepmc   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, Volume 12, Issue 21, June 5, 2025.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

CD133+CD24+ Renal Tubular Progenitor Cells Drive Hypoxic Injury Recovery via Hypoxia-Inducible Factor-1A and Epidermal Growth Factor Receptor Expression. [PDF]

Int J Mol Sci
Al-Marsoummi S, Singhal S, Garrett SH, Somji S, Sens DA, Singhal SK.   +5 more
europepmc   +1 more source

Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells [PDF]

, 2017
Mercè Padró, Raymond J. Louie, Brian V. Lananna, Adam J. Krieg, Luika A. Timmerman, Denise A. Chan   +5 more
core   +1 more source

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Advanced Science, Volume 12, Issue 21, June 5, 2025.
MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pinyi Liu, Lei Ye, Siyi Xu, Junqiu Jia, Shu Shu, Huiya Li, Yanping Yin, Shengnan Xia, Yanting Chen, Yun Xu   +13 more
wiley   +1 more source