Results 261 to 270 of about 678,452 (368)

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Evaluation of dry eye syndrome in patients with obstructive sleep apnea syndrome based on serum hypoxia-inducible factor 1 alpha (HIF-1α), matrix metalloproteinase 2 (MMP-2), and desmosine levels. [PDF]

BMC Ophthalmol
Okutucu M, Sağır B, Şahin Ü, Arpa M, Yılmaz E, Uzun F, Fındık H, Kaim M, Halili E.   +8 more
europepmc   +1 more source

1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia

, 2012
Petr Váchal, Shouwu Miao, Joan M. Pierce, Deodial Guiadeen, Vincent J. Colandrea, Matthew J. Wyvratt, Scott P. Salowe, Lisa M. Sonatore, James A. Milligan, Richard Hajdu, Anantha Gollapudi, Carol Keohane, Russell B. Lingham, Suzanne Mandala, Julie A. DeMartino, Xinchun Tong, Michael W. Wolff, Dietrich Steinhuebel, G. R. KIECZYKOWSKI, Fred J. Fleitz, Kevin T. Chapman, John Athanasopoulos, Gregory C. Adam, Can D. Akyuz, Dhirendra K. Jena, Jeffrey W. Lusen, Juncai Meng, Benjamin D. Stein, Lei Xia, Edward C. Sherer, Jeffrey J. Hale   +30 more
openalex   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Hypoxia-Inducible Factor 1-Alpha Gene Polymorphisms Impact Risk of Severespectrum Hypertensive Disorders of Pregnancy: A Case-Control Study. [PDF]

Reprod Sci
Baldauf C, Wei C, Pickering TA, Grubbs B, Gjessing H, Wilson ML.   +5 more
europepmc   +1 more source

Hypoxia‐inducible factor 1–mediated human GATA1 induction promotes erythroid differentiation under hypoxic conditions

, 2011
Fenglin Zhang, Guomin Shen, Xiaoling Liu, Fang Wang, Yingze Zhao, Jun‐Wu Zhang   +5 more
openalex   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Nanoscale Systems for Local Activation of Hypoxia-Inducible Factor-1 Alpha: A New Approach in Diabetic Wound Management. [PDF]

Int J Nanomedicine
Saber S, Abdelhady R, Elhemely MA, Elmorsy EA, Hamad RS, Abdel-Reheim MA, El-Kott AF, AlShehri MA, Morsy K, Negm S, Kira AY.   +10 more
europepmc   +1 more source

ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression [PDF]

, 2012
Frédérique Fallone, Sébastien Britton, Laurence Nieto, Bernard Salles, Catherine Müller   +4 more
openalex   +1 more source