Results 261 to 270 of about 649,237 (386)

Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis. [PDF]

Nat Commun
Kavaliauskas P, Gu Y, Hasin N, Graf KT, Alqarihi A, Shetty AC, McCracken C, Walsh TJ, Ibrahim AS, Bruno VM.   +9 more
europepmc   +1 more source

Effect of umbilical cord mesenchymal stem cells on hypoxia-inducible factor-1 alpha (HIF-1α) production in arteriovenous fistula (AVF) animal model: A preliminary study. [PDF]

Narra J, 2023
Habibie YA, Emril DR, Azharuddin A, Syahrizal D.   +3 more
europepmc   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Hypoxia-Inducible Factor-1 Activation by (−)-Epicatechin Gallate: Potential Adverse Effects of Cancer Chemoprevention with High-Dose Green Tea Extracts [PDF]

, 2004
Yu‐Dong Zhou, Yong-Pil Kim, Xing-Cong Li, Scott R. Baerson, Ameeta K. Agarwal, Tyler W. Hodges, Daneel Ferreira, Dale G. Nagle   +7 more
openalex   +1 more source

Harnessing the power of pericytes and hypoxia-inducible factor-1 to modulate stroke outcome. [PDF]

Neural Regen Res
Ogunshola OO, Tsao CC.
europepmc   +1 more source

Hypoxia-Inducible Factor 1-Alpha Stabilizers in the Treatment of Inflammatory Bowel Diseases: Oxygen as a Novel IBD Therapy? [PDF]

J Crohns Colitis, 2022
Bhat S, Rieder F.
europepmc   +1 more source

Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

Advanced Science, EarlyView.
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu   +13 more
wiley   +1 more source

The gene encoding human retinoic acid-receptor-related orphan receptor α is a target for hypoxia-inducible factor 1 [PDF]

, 2004
Caroline Chauvet, Brigitte Bois-Joyeux, Edurne Berra, Jacques Pouysségur, Jean-Louis Danan   +4 more
openalex   +1 more source

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source

Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia [PDF]

, 2004
Guoxiang Yuan, Jayasri Nanduri, C. Raman Bhasker, Gregg L. Semenza, Nanduri R. Prabhakar   +4 more
openalex   +1 more source