Results 251 to 260 of about 229,207 (357)

Iron Chelators in the Management of Autoimmune-Induced Alopecia: A Focus on Hypoxia-Inducible Factor 1 Modulation and Hair Restoration. [PDF]

J Clin Med
Pagani A, Thor D, Panayi AC, Klein SM, Geis S, Knoedler L, Knoedler S, Perozzo FAG, Sofo G, Loucas R, Prantl L, Duscher D.   +11 more
europepmc   +1 more source

The gene encoding human retinoic acid-receptor-related orphan receptor α is a target for hypoxia-inducible factor 1

, 2004
Caroline Chauvet, Brigitte Bois-Joyeux, Edurne Berra, Jacques Pouysségur, Jean-Louis Danan   +4 more
openalex   +2 more sources

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Hypoxia-Inducible Factor 1-alpha (HIF1α), Nicotinamide Adenine Dinucleotide (NAD+, NADH), and Nitric Oxide (NO) interplay in critically ill patients, with implications for patient safety and targeted therapies: a review. [PDF]

Patient Saf Surg
Bar-Or D, Banton K, Acuna D, Williams J, Palacio CH, Mains CW, Garrett R.   +6 more
europepmc   +1 more source

Tale of two transcription factors: NF-кB and HIF crosstalk [PDF]

, 2013
Bandarra, D., Rocha, S.
core   +1 more source

Mammalian oxygen sensing and hypoxia inducible factor-1

The International Journal of Biochemistry & Cell Biology, 1997
Wood, S, Ratcliffe, P
openaire   +2 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia-Inducible Factor-1 Signaling Pathway. [PDF]

Adv Sci (Weinh)
Zhao LN, Wang RL, Liu RX, Zheng MR, Zhao L, Li BF, Li JL, Liu DS, He XX, Peng QB, Li K, Lin TX, Liu YY, He SP, Lu J, Zheng SY, Liu X, Huang FZ.   +17 more
europepmc   +1 more source

Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1α

, 2010
Masashi Ueda, Takashi Kudo, Yuji Kuge, Takahiro Mukai, Shotaro Tanaka, Hiroaki Konishi, Azusa Miyano, Masahiro Ono, Shinae Kizaka‐Kondoh, Masahiro Hiraoka, Hideo Saji   +10 more
openalex   +2 more sources

RENAL‐CHIP: Rejection Evaluation via Non‐Invasive Analysis of Circulating Podocytes With Herringbone‐Chip Isolation Platform

Advanced Science, EarlyView.
RENAL‐CHIP converts 1 mL of peripheral blood into a biopsy‐equivalent readout of renal‐allograft fate. By magnetic capture and release of donor‐derived circulating podocytes through a herringbone microfluidic chip, 84% capture, 96% release and single‐cell RNA evidence of rejection‐specific immunity are achieved.
Juan Song, Yilong Liu, Zeyuan Zheng, Ming Zhu, Yuning Zou, Pei Liu, Yue Zheng, Xiyuan Yu, Jianzhong Zheng, Chen Shao, Huimin Zhang, Chaoyong Yang   +11 more
wiley   +1 more source