Results 271 to 280 of about 1,344,802 (358)

The role of hypoxia inducible factor-1α in the increased MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles

, 2011
Rong Wan, Yiqun Mo, Sufan Chien, Yihua Li, Yixin Li, David J. Tollerud, Qunwei Zhang   +6 more
openalex   +1 more source

Isoform-Specific Expression of Hypoxia-Inducible Factor-1α During the Late Stages of Mouse Spermiogenesis [PDF]

, 2002
Hugo H. Marti, Dörthe M. Katschinski, Klaus Wagner, Leonhard Schäffer, Bettina Stier, Roland H. Wenger   +5 more
openalex   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function. [PDF]

Front Immunol, 2023
Vanderhaeghen T, Timmermans S, Eggermont M, Watts D, Vandewalle J, Wallaeys C, Nuyttens L, De Temmerman J, Hochepied T, Dewaele S, Berghe JV, Sanders N, Wielockx B, Beyaert R, Libert C.   +14 more
europepmc   +1 more source

Hypoxia Inducible Factor-2 Alpha and Prolinhydroxylase 2 Polymorphisms in Patients with Acute Respiratory Distress Syndrome (ARDS) [PDF]

, 2017
Annika Dötsch, Lewin Eisele, Miriam Rabeling, Katharina Rump, Kai Walstein, Alexandra Bick, Linda Cox, Andrea Engler, Hagen S. Bachmann, Karl‐Heinz Jöckel, Michael Adamzik, Jürgen Peters, Simon Schäfer   +12 more
openalex   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Therapeutic Targeting of Hypoxia-Inducible Factors in Cancer. [PDF]

Int J Mol Sci
Musleh Ud Din S, Streit SG, Huynh BT, Hana C, Abraham AN, Hussein A.   +5 more
europepmc   +1 more source

Hypoxia-Inducible Factors and Burn-Associated Acute Kidney Injury-A New Paradigm? [PDF]

Int J Mol Sci, 2022
Enescu DM, Parasca SV, Badoiu SC, Miricescu D, Ripszky Totan A, Stanescu-Spinu II, Greabu M, Jinga V.   +7 more
europepmc   +1 more source

Advances on hypoxia inducible factor-1

Chinese Medical Journal, 2013
Xiao-Jun, Wang, Lou-Bin, Si
openaire   +2 more sources

Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension

Advanced Science, EarlyView.
Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu, Min Chen, Chen‐Yu Jiang, Dai‐Ji Jiang, Xu Zhang, Xiao‐He Xu, Yi‐Wei Liu, Bei Feng, Lin‐Cai Ye, Yang‐Yang He, Xu Huang, Yi‐Chi Zhang, Xing‐Liang Zhou, Yi Shen, Tian‐Yu Liu, Li‐Jun Fu, Yi Yan, Hao Zhang   +17 more
wiley   +1 more source