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Mitochondria and Hypoxia‐induced Gene Expression Mediated by Hypoxia‐inducible Factors
Annals of the New York Academy of Sciences, 2008The influence of mitochondrial activity on gene expression programs, particularly those involved in neuroprotection and repair, is likely to play an important role in the pathophysiology of neurodegenerative diseases. One such gene expression program is activated by the cellular pathway that senses a decrease in optimal oxygen levels and leads to ...
Angela, Chavez +3 more
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Hypoxia-induced radioresistance is independent of hypoxia-inducible factor-1A in vitro
International Journal of Radiation Oncology*Biology*Physics, 2005We sought to determine whether hypoxia-induced radioresistance is mediated by the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha).We used 2 mouse embryonic fibroblast cell lines transformed with H-ras and TAg, 1 HIF-1alpha+/+ and the other HIF-1alpha-/-.
Nils D, Arvold +6 more
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The role of hypoxia-inducible factors in cancer
Cellular and Molecular Life Sciences, 2007Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that mediates the adaptive responses to hypoxia by effecting the transcription of numerous hypoxia-inducible genes. HIF is frequently overexpressed in solid tumors, and the transactivation of HIF targets in transformed cells provides a distinct survival advantage.
M A, Maynard, M, Ohh
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Hypoxia inducible factors in the tumor microenvironment as therapeutic targets of cancer stem cells.
Life Science, 2019Cancer stem cells (CSC) constitute a small area of the tumor mass and are characterized by self-renewal, differentiation and the ability to promote the development of secondary chemo-resistant tumors.
Farnaz Hajizadeh +8 more
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Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors.
Biochimica et biophysica acta. Reviews on cancer, 2018Cancer cells are characterized by high metabolic demand. The substrates in demand include oxygen, glucose, glutamine and lipids. Oxygen serves as a key substrate in cellular metabolism and bioenergetics.
Debangshu Samanta, G. Semenza
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Redox regulation of the hypoxia-inducible factor
Biological Chemistry, 2006Reactive oxygen species (ROS) have long been considered only as cyto- and genotoxic. However, there is now compelling evidence that ROS also act as second messengers in response to various stimuli, such as growth factors, hormones and cytokines. The hypoxia-inducible transcription factor (HIF) is a master regulator of oxygen-sensitive gene expression ...
Pouysségur, Jacques +1 more
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Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1
Biochemical and Biophysical Research Communications, 2001ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the ...
M, Oikawa +5 more
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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Nature, 1999P. Maxwell +9 more
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Hypoxia‐Inducible Factor 1 Inhibitors
2007The tremendous progress in our understanding of the molecular mechanisms underlying the presence and consequences of hypoxia in human cancers has been accompanied by renewed enthusiasm for the development of therapeutic strategies targeting hypoxic cells signaling pathways.
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