Results 281 to 290 of about 1,301,346 (361)

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

WHOLE TRANSCRIPTION ANALYSIS IDENTIFIED THE REGULATION OF HYPOXIA-INDUCIBLE FACTORS IN MONOCYTES WITH IMMUNE SUPPRESSION: IMPLICATIONS FOR CLINICAL OUTCOMES. [PDF]

Shock
Zhao S, Li H, Luo W, Hu Z, Wang Y, Liu T, Zhang Y, Dai R.   +7 more
europepmc   +1 more source

Hypoxia‐inducible factor‐1α (HIF‐1α) escapes O₂‐driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm [PDF]

, 2001
Edurne Berra, Danièle Roux, Darren E. Richard, Jacques Pouysségur   +3 more
openalex   +1 more source

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source

The mitochondrial Na⁺/Ca²⁺ exchanger NCLX is implied in the activation of hypoxia-inducible factors. [PDF]

Redox Biol
Choya-Foces C, Navarro E, Ríos CL, López MG, Egea J, Hernansanz-Agustín P, Martínez-Ruiz A.   +6 more
europepmc   +1 more source

Cobalt Induces Heme Oxygenase-1 Expression by a Hypoxia-inducible Factor-independent Mechanism in Chinese Hamster Ovary Cells [PDF]

, 2001
Pengfei Gong, Bin Hu, Daniel P. Stewart, Michael Ellerbe, Yanira G. Figueroa, Volker Blank, Barbara S. Beckman, Jawed Alam   +7 more
openalex   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Selective Overexpression of the Hypoxia-Inducible Transcription Factor, HIF-2α, in Placentas from Women with Preeclampsia1

, 2001
Augustine Rajakumar, Kerry A. Whitelock, Lisa A. Weissfeld, Ashi Daftary, Nina Marković, Kirk P. Conrad   +5 more
openalex   +1 more source

Induction of Vascular Endothelial Growth Factor Expression and Hypoxia-inducible Factor 1α Protein by the Oxidative Stressor Arsenite [PDF]

, 2001
Monique C.A. Duyndam, T.M. Hulscher, Dennis Fontijn, Herbert M. Pinedo, Epie Boven   +4 more
openalex   +1 more source

The role of hypoxia‐inducible factors in carotid body (patho) physiology

Journal of Physiology, 2018
G. Semenza, N. Prabhakar
semanticscholar   +1 more source