Results 171 to 180 of about 44,731 (245)

Human Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Attenuate Renal Fibrosis by Suppressing Fibroblast Activation via the INHBA/PI3K/AKT Pathway

open access: yesPediatric Discovery, EarlyView.
MSC‐Exo derived from human umbilical cord (HucMSC‐Exo) downregulates INHBA expression, consequently modulating the PI3K/AKT signaling cascade. This regulation attenuates renal fibroblast activation and extracellular matrix deposition, thereby exerting a renoprotective effect against fibrosis.
Meiling Chen   +11 more
wiley   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

open access: yesPrecision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Nomogram integrating MRI radiomics and white matter hyperintensity grading for predicting overall survival in patients with non‐small cell lung cancer and brain metastases receiving whole‐brain radiotherapy

open access: yesPrecision Radiation Oncology, EarlyView.
A prognostic nomogram integrating radiomic features and white matter hyperintensity (WMH) grading was developed to enable individualized survival prediction in patients with brain metastases (BMs). Integration of these imaging biomarkers into the clinical model enhanced predictive performance, indicating their incremental prognostic value for BM ...
Jianan Ni   +7 more
wiley   +1 more source

Nocturnal awakening secondary to pain in sleep‐related painful erection: A case report and literature review

open access: yesSleep Research, EarlyView.
Abstract A 41‐year‐old male patient presented with a 13‐year history of recurrent nocturnal penile pain associated with erections during sleep. Over the course of his illness, the patient attended outpatient clinics on 298 occasions and was hospitalized three times. The primary symptom reported was erectile pain occurring during sleep.
Liping Zhang   +5 more
wiley   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

open access: yesVIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang   +5 more
wiley   +1 more source

Biomarkers to predict outcomes in diabetic foot ulcers

open access: yesVIEW, EarlyView.
Studies attempting to predict the healing outcome of diabetic foot ulcers (DFUs) have investigated various biological materials and recovered molecules that may aid in discriminating wounds that will heal and those that will not heal. This graphical abstract captures the commonly studied classes of biomarkers in the context of DFUs.
Julie Okiro   +6 more
wiley   +1 more source

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