Results 201 to 210 of about 44,731 (245)

Pathophysiology of perinatal hypoxia–ischaemia

Paediatrics and Child Health, 2010
Abstract Over the last 30 years there has been an increasing body of literature that has characterized the complex cascade of events that leads to neuronal and glial cell injury following perinatal hypoxia–ischaemia. Understanding the pathophysiology of hypoxic-ischaemic encephalopathy is important as this helps in delivering optimal targeted ...
Anitha James, Shobha Cherian
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Enteral hypoxia/ischaemia and necrotizing enterocolitis

Seminars in Neonatology, 1997
The intestinal circulation normally meets the bowel's metabolic needs, but adaptive responses may sacrifice flow to the intestine to preserve the oxygenation of other organs. Severe or prolonged hypoxia associated with birth asphyxia or intrauterine growth restriction may predispose to necrotizing enterocolitis (NEC) by repeated or persistent ...
H.R. Gamsu, S.T. Kempley
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Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia–ischaemia [PDF]

Journal of Neurochemistry, 2006
AbstractSex‐related brain injury was evaluated after unilateral hypoxia–ischaemia (HI) in C57/BL6 mice on postnatal day (P) 5, 9, 21 or 60, corresponding developmentally to premature, term, juvenile and adult human brains. There was no sex difference in brain injury when the insult was severe, as evaluated by pathological scoring or tissue loss, but ...
Changlian Zhu, Falin Xu, Xiaoyang Wang   +2 more
exaly   +3 more sources

Management of renal dysfunction following term perinatal hypoxia‐ischaemia

Acta Paediatrica, 2013
AbstractAcute kidney injury frequently develops following the term perinatal hypoxia‐ischaemia. Quantifying the degree of acute kidney injury is difficult, however, as the methods currently in use are suboptimal. Acute kidney injury management is largely supportive with little evidence basis for many interventions.
Sweetman, Deirdre U, Riordan, Michael, Molloy, Eleanor J   +2 more
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Hypoxia‐ischaemia model in the 7‐day‐old rat: possibilities and shortcomings

Acta Paediatrica, International Journal of Paediatrics, 1997
The Levene model in 7‐day‐old rats is the most often used model of hypoxia—ischaemia (HI) in immature animals. The rat central nervous system is immature at birth and corresponds neurodevelopmentally to the term human infant during the second postnatal week.
Henrik Hagberg, Elsa Bona, E Gilland
exaly   +3 more sources

Protecting the term newborn brain following hypoxia–ischaemia

Current Paediatrics, 2002
Abstract Following hypoxia–ischaemia, prompt resuscitation is required to re-establish oxygenation and perfusion. Thereafter, the clinical condition requires strict attention to detail. Ventilation may be required to ensure oxygenation; hyperventilation must be avoided. Myocardial dysfunction is common and inotropes may be required to support cerebral
David Evans, Bharati Sinha
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Activation of ERK1/2 after neonatal rat cerebral hypoxia–ischaemia

Journal of Neurochemistry, 2003
AbstractActivation of extracellular signal‐related kinases (ERK1/2), also known as p42/44 mitogen‐activated protein kinase (MAPK), is considered important for neuronal survival, cell proliferation and apoptosis. In the present study, activation (phosphorylation) of ERK1/2 (P‐ERK) was investigated in brains of 7‐day‐oldrats after hypoxia‐ischaemia (HI).
Xiaoyang, Wang, Changlian, Zhu, Lin, Qiu, Henrik, Hagberg, Mats, Sandberg, Klas, Blomgren   +5 more
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An improved survival model of hypoxia/ischaemia in the piglet suitable for neuroprotection studies

Brain Research, 2001
The purpose of this study was to develop a newborn piglet model of hypoxia/ischaemia which would better emulate the clinical situation in the asphyxiated human neonate and produce a consistent degree of histopathological injury following the insult. One-day-old piglets (n=18) were anaesthetised with a mixture of propofol (10 mg/kg/h) and alfentinal (55.
Foster, K. A., Colditz, P. B., Lingwood, B. E., Burke, C., Dunster, K. R., Roberts, M. S.   +5 more
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Distortion product otoacoustic emissions in term infants after hypoxia-ischaemia

European Journal of Pediatrics, 2004
Distortion product otoacoustic emissions (DPOAEs) were recorded in 46 term infants who suffered perinatal hypoxia-ischaemia to identify which frequencies in the cochlear audiogram are susceptible to perinatal hypoxia-ischaemia. On days 3-5 after birth, the pass rates across the frequencies of the f(2 )primary tone between 1 and 10 kHz, particularly 1-5
Ze Dong, Jiang, Zheng, Zhang, Andrew Robert, Wilkinson   +2 more
openaire   +2 more sources