Results 211 to 220 of about 44,731 (245)
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Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia–ischaemia
Neuropathology and Applied Neurobiology, 1997We have used a porcine model of global hypoxia-ischaemia to examine the mode and extent of cell damage to the newborn brain. Apoptosis and necrosis were observed in neurons and glial cells following transient cerebral hypoxic-ischaemic injury (HII) by haematoxylin and eosin staining and by in situ end labelling (ISEL).
H Mehmet +2 more
exaly +4 more sources
Neonatal hypoxia–ischaemia disrupts descending neural inputs to dorsal raphé nuclei
Neuroscience, 2013Neuronal losses have been shown to occur in the brainstem following a neonatal hypoxic-ischaemic (HI) insult. In particular serotonergic neurons, situated in the dorsal raphé nuclei, appear to be vulnerable to HI injury. Nonetheless the mechanisms contributing to losses of serotonergic neurons in the brainstem remain to be elucidated.
Reinebrant H.E., Wixey J.A., Buller K.M.
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Cerebral impedance following hypoxia/ischaemia in the human infant
2007Changes in cerebral impedance are able to discriminate, within 1-2 hours of acute hypoxia in the newborn piglet, between animals which will have a good neurological outcome, and those who have suffered a more severe insult resulting in a poor outcome. The aim of this study was to determine if cerebral impedance is useful in the human infant for early ...
Lingwood, BE +6 more
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Evaluation of inhaled NO in a model of rat neonate brain injury caused by hypoxia–ischaemia
Injury, 2010Inhaled NO (INO), at 5-40 parts per million (ppm) in the air, is indicated for treating neonatal hypoxic respiratory failure. Whether these doses of INO are protective or toxic towards brain was here evaluated in laboratory animals.In rat neonates (postnatal day 7), a brain injury based on permanent right carotid artery occlusion plus transient (90 min)
Joriot-Chekaf, Sylvie +6 more
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Depressed brainstem auditory electrophysiology in preterm infants after perinatal hypoxia–ischaemia
Journal of the Neurological Sciences, 2009Our understanding of pathophysiology of hypoxic-ischemic brain damage in preterm infants remains very limited. We studied the amplitudes of brainstem auditory evoked response, recorded with 91-910/s clicks, at term in preterm infants after perinatal HI for functional status of the auditory brainstem.
Ze D, Jiang +2 more
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Hypoxic preconditioning reduces apoptosis in a rat model of immature brain hypoxia-ischaemia
Neuroscience Letters, 2003Hypoxic events are common in newborns but their consequences on brain development have not been demonstrated. It has been reported that in newborn animal models of cerebral hypoxic-ischaemic insult, short-term hypoxia before the insult completely prevented brain damage. The mechanisms of this brain tolerance have not been fully elucidated.
Sylvain, Cantagrel +7 more
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1991
The constituents forming the purine pool play a pivotal role in virtually all cellular functions.1,2 That implicates thermodynamic, kinetic as well as regulatory aspects. ATP, for instance, is best described as a kinetically versatile agent integrated in cell functions as an energy transducer, not as a source or store of energy.3 There exists a mutual ...
G, Gerber +7 more
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The constituents forming the purine pool play a pivotal role in virtually all cellular functions.1,2 That implicates thermodynamic, kinetic as well as regulatory aspects. ATP, for instance, is best described as a kinetically versatile agent integrated in cell functions as an energy transducer, not as a source or store of energy.3 There exists a mutual ...
G, Gerber +7 more
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Endogenous neuroprotection after perinatal hypoxia‐ischaemia: the resilient developing brain
Journal of the Royal Society of New Zealand, 2018ABSTRACT The mammalian fetus and newborn can survive far more prolonged periods of hypoxia‐ischaemia without neural injury than adults. In part, this remarkable physiological resilience reflects the effectiveness of its endogenous protective processes that help to suppress injurious events that evolve over time after hypoxia‐ischaemia
Joanne O. Davidson +5 more
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Journal of Experimental Biology, 1996
ABSTRACT Marmots (Marmota flaviventris) are burrowing mammals that may be subjected to low levels of oxygen and high levels of carbon dioxide in their underground environment. Since marmots successfully deal with this physiological challenge, we hypothesized that the isolated perfused marmot heart would be damaged less and recover better
T, McKean, W, Mendenhall
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ABSTRACT Marmots (Marmota flaviventris) are burrowing mammals that may be subjected to low levels of oxygen and high levels of carbon dioxide in their underground environment. Since marmots successfully deal with this physiological challenge, we hypothesized that the isolated perfused marmot heart would be damaged less and recover better
T, McKean, W, Mendenhall
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KCC2 expression changes in Diazepam-treated neonatal rats with hypoxia-ischaemia brain damage
Brain Research, 2014Hypoxia-ischaemia brain damage (HIBD) is a major type of perinatal brain injury in newborns. In this study, we investigate the short- and long-term neuroprotective effects of Diazepam on neonatal rats with HIBD and the potential mechanisms underlying its protective effects.
Jun-Yuan, Ma +7 more
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