Results 71 to 80 of about 216,063 (137)

Delayed necrostatin-1s infusion attenuates cystic white matter injury in preterm fetal sheep

Neurotherapeutics
Severe, cystic white matter injury (WMI) in preterm infants is associated with neurodevelopmental impairment. Strikingly, it often develops weeks after birth. In the present study we tested the hypothesis that necrotic programmed cell death, necroptosis,
Benjamin A. Lear, Christopher A. Lear, Simerdeep K. Dhillon, Victoria J. King, Justin M. Dean, Joanne O. Davidson, Alistair J. Gunn, Laura Bennet   +7 more
doaj   +1 more source

Ca2+ ionophores are not suitable for inducing mPTP opening in murine isolated adult cardiac myocytes

Scientific Reports, 2017
Opening of the mitochondrial permeability transition pore (mPTP) plays a major role in cell death during cardiac ischaemia-reperfusion. Adult isolated rodent cardiomyocytes are valuable cells to study the effect of drugs targeting mPTP.
Mathieu Panel, Bijan Ghaleh, Didier Morin   +2 more
doaj   +1 more source

Tertiary cystic white matter injury as a potential phenomenon after hypoxia-ischaemia in preterm f sheep. [PDF]

Brain Commun, 2021
Lear BA, Lear CA, Davidson JO, Sae-Jiw J, Lloyd JM, Gunn AJ, Bennet L.   +6 more
europepmc   +1 more source

The role of PTEN in cardioprotection against ischaemia-reperfusion injury [PDF]

, 2009
Activation of the PI3K/AKT pathway protects the heart from ischaemia-reperfusion injury. Phosphatase and Tensin Homolog deleted on Chromosome10 (PTEN) is a negative regulator of this pathway.
Siddall, H.K.
core  

Renal microcirculation in acute kidney injury: bridging haemodynamics, inflammation and repair

Annals of Intensive Care
Background: The kidneys receive a disproportionately high share of cardiac output relative to their mass, reflecting their central role in solute clearance and fluid regulation.
Stanislas Abrard, John R. Prowle, Philippe Guerci, Didier Payen, Thomas Rimmelé   +4 more
doaj   +1 more source

Defining a Time Window for Neuroprotection and Glia Modulation by Caffeine After Neonatal Hypoxia-Ischaemia. [PDF]

Mol Neurobiol, 2020
Di Martino E, Bocchetta E, Tsuji S, Mukai T, Harris RA, Blomgren K, Ådén U.   +6 more
europepmc   +1 more source

The role of endotoxin, the TNF family of cytokines and intracellular pH in perinatal hypoxic-ischemic brain injury [PDF]

, 2010
To explore the effect of endotoxin as a sensitising agent prior to neonatal hypoxiaischemia differing doses of endotoxin (E. coli lipopolysaccharide, LPS) were given to neonatal mice prior to hypoxia-ischemia, with sensitising effects noted at dosages ...
Kendall, G.
core  

Alpha-adrenergic mediated changes in blood pressure variability after hypoxia-ischaemia in preterm fetal sheep. [PDF]

J Physiol
Dhillon SK, Beacom MJ, King VJ, Nakao M, Lear OJ, Lear CA, Lear BA, Davidson JO, Gunn AJ, Bennet L.   +9 more
europepmc   +1 more source

Ongoing loss of viable neurons for weeks after mild hypoxia-ischaemia. [PDF]

Brain Commun
McNally MA, Lau LA, Granak S, Hike D, Liu X, Yu X, Donahue RA, Chibnik LB, Ortiz JV, Che A, Chavez-Valdez R, Northington FJ, Staley KJ.   +12 more
europepmc   +1 more source

Impact of neonatal hypoxia-ischaemia on oligodendrocyte survival, maturation and myelinating potential. [PDF]

J Cell Mol Med, 2018
Ziemka-Nalecz M, Janowska J, Strojek L, Jaworska J, Zalewska T, Frontczak-Baniewicz M, Sypecka J.   +6 more
europepmc   +1 more source