Results 61 to 70 of about 216,063 (137)

Translational perspectives on neurophysiological responses and mechanisms in blood flow restriction exercise

Experimental Physiology
Maintaining corticospinal tract function is crucial for voluntary movement. Exercise using high external loads/intensities is a promising intervention to promote adaptations to the corticospinal tract and improve physical function; however, such loads ...
Kai T. Fox, Luke Hughes, Brendan R. Scott, Paul S. R. Goods, Shaun YM. Teo, Ann‐Maree Vallence   +5 more
doaj   +1 more source

Emerging therapy strategies for energy metabolism in acute myocardial infarction

Journal of Translational Medicine
Acute myocardial infarction (AMI) is a life-threatening cardiovascular event caused by the sudden blockage of a coronary artery, usually triggered by thrombotic events.
Ruixin Ma, Dazhou Lu, Zeyu Yang, Xiaohang Ji, Rui Tian, Feng Xu, Yuguo Chen, Chuanbao Li   +7 more
doaj   +1 more source

A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies.

PLoS ONE, 2017
BackgroundStromal derived factor-1α (SDF-1α/CXCL12) is a chemokine that is up-regulated in diseases characterised by tissue hypoxia, including myocardial infarction, ischaemic cardiomyopathy and remote ischaemic conditioning (RIC), a technique of ...
Daniel I Bromage, Stasa Taferner, Mahesh Pillai, Derek M Yellon, Sean M Davidson   +4 more
doaj   +1 more source

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Feelisch, Martin, Umbrello, Michele, Dyson, Alex, Singer, Mervyn   +3 more
core   +1 more source

LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes. [PDF]

J Cell Mol Med, 2022
Gu J, Shi JZ, Wang YX, Liu L, Wang SB, Sun JT, Shan TK, Wang H, Wang QM, Wang LS.   +9 more
europepmc   +1 more source

Alpha-adrenergic receptor activation after fetal hypoxia-ischaemia suppresses transient epileptiform activity and limits loss of oligodendrocytes and hippocampal neurons. [PDF]

J Cereb Blood Flow Metab, 2023
Dhillon SK, Gunn ER, Pedersen MV, Lear CA, Wassink G, Davidson JO, Gunn AJ, Bennet L.   +7 more
europepmc   +1 more source

Hypoxia regulated pathways in urological malignancies

, 2009
Introduction: Kidney Cancer accounts for approximately 2% of all new cancer diagnoses inthe UK each year. Patient survival has improved over the past few decades; however themechanisms of this are yet to be fully elucidated.
Charlesworth, Philip J.S., Charlesworth, Philip J S   +1 more
core   +1 more source

Ventilatory response and delirium risk in hospitalised patients with acute hypoxia due to COVID-19

Scientific Reports
Mountaineers with a high ventilatory response to hypoxia experience greater cognitive impairment at high altitude, possibly because hyperventilation causes hypocapnia, cerebral vasoconstriction and ultimately cerebral ischaemia.
Nikolai Ravn Aarskog, Hanna Othilie Lindvig Bjørsrud, Aleksander Rygh Holten, Leiv Otto Watne, Bjørn Erik Neerland, Morten Rostrup   +5 more
doaj   +1 more source

Effects of delayed HIF-1α expression in astrocytes on myelination following hypoxia-ischaemia white matter injury in immature rats. [PDF]

Transl Pediatr, 2022
Wang MJ, Li ZH, Gao RW, Chen QF, Lin J, Xiao ML, Zhang K, Chen C.   +7 more
europepmc   +1 more source

Down-regulation of the hypothalamo-pituitary-adrenal axis reduces brain damage and number of seizures following hypoxia/ischaemia in rats

, 1995
Several reports suggest that the activity of the hypothalamo-pituitary-adrenal axis (HPA-axis) is increased following hypoxia/ischaemia and that this might be associated with increased neuronal vulnerability.
Knollema, Siert, TERHORST, GJ, Krugers, Harm J., Kemper, Richard H. A., KRUGERS, HJ, KORF, J, KNOLLEMA, S, KEMPER, RHA, Korf, Jakob, Ter Horst, Gert J.   +9 more
core   +1 more source