Results 101 to 110 of about 927,905 (356)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

1H-NMR urine metabolomic fingerprint for severity discrimination in pulmonary sarcoidosis

ERJ Open Research
Background Sarcoidosis is a systemic inflammatory immune disease characterised by noncaseating granulomas. Its course can vary from benign to very severe, requiring appropriate treatment.
Florence Jeny, Mohamed Nawfal Triba, Simon Chauveau, Dominique Valeyre, Sabrina Mokhtari, Hilario Nunes, Jean-Francois Bernaudin, Philippe Savarin   +7 more
doaj   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory response

Immunobiology
Sepsis, with high morbidity and mortality, represents a systemic inflammatory response syndrome. A common consequence of sepsis is acute lung injury (ALI).
Minxia Zhu, Yaqi Lei, Zhaojun Zhang, Xu Guo, Jing Guo, Ruipeng Wu, Xiaofeng Li, Shibo Tian, Yuanhao Zhao   +8 more
doaj   +1 more source

HIF-1α Contributes to Hypoxia-induced Invasion and Metastasis of Esophageal Carcinoma via Inhibiting E-cadherin and Promoting MMP-2 Expression [PDF]

, 2012
Hypoxia-inducible factor-1α (HIF-1α) has been found to enhance tumor invasion and metastasis, but no study has reported its action in esophageal carcinoma.
Cheng, Yun-Jie, Jing, Shao-Wu, Kuroda, Masahiro, Liu, Qing, Su, Jing-Wei, Sun, Guo-Gui, Wang, Ya-Di, Yang, Cong-Rong   +7 more
core   +1 more source

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source

The Linkage between Breast Cancer, Hypoxia, and Adipose Tissue

Frontiers in Oncology, 2017
ObjectiveThe development of breast cancer cells is linked to hypoxia. The hypoxia-induced factor HIF-1α influences metastasis through neovascularization. Hypoxia seems to decrease the responsiveness to hormonal treatment due to loss of estrogen receptors
Linda K. Rausch, Linda K. Rausch, Nikolaus C. Netzer, Nikolaus C. Netzer, Nikolaus C. Netzer, Josef Hoegel, Stephan Pramsohler   +6 more
doaj   +1 more source

Lower Body Weight in Rats Under Hypobaric Hypoxia Exposure Would Lead to Reduced Right Ventricular Hypertrophy and Increased AMPK Activation

Frontiers in Physiology, 2020
BackgroundBoth chronic hypoxia (CH) and long-term chronic intermittent hypoxia (CIH) exposure lead to right ventricular hypertrophy (RVH). Weight loss is an effective intervention to improve cardiac function and energy metabolism in cardiac hypertrophy ...
Karen Flores, Karen Flores, Patricia Siques, Patricia Siques, Julio Brito, Julio Brito, Stefany Ordenes, Stefany Ordenes, Karem Arriaza, Karem Arriaza, E. Pena, E. Pena, Fabiola León-Velarde, Rosario López, Ángel L. López de Pablo, Silvia Arribas   +15 more
doaj   +1 more source

Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1 [PDF]

, 2018
Sphingosine kinase 1 (SphK1) upregulation is associated with pathologic pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), but the mechanisms controlling its expression are undefined.
Chen, Jiwang, Comhair, Suzy, Machado, Roberto F., Natarajan, Viswanathan, Singla, Sunit, Sysol, Justin R., Zhao, Shuangping   +6 more
core   +1 more source