Results 101 to 110 of about 939,686 (311)

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

IL-4 polymorphisms (rs2227284, rs2243267, and rs2243270) are associated with reduced risk of rheumatoid arthritis

Autoimmunity
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease, and understanding its genetic and molecular basis is crucial for early diagnosis, treatment, and prevention.Objective This study aims to explore the association between IL-4 ...
Xiaoli Liu, Huqiang Mai, Liang Wang, Hengxun Zhang, Xuemei Li, Xuguang Li, Li Wang   +6 more
doaj   +1 more source

HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer.
Blokland, NJG, Broos, AWT, Eccles, SA, Hammond, EM, Harvey, AJ, Pires, IM, Poujade, F-A, Senra, JM, Span, PN   +8 more
core   +3 more sources

Oligohistidine‐Functionalized Single‐Walled Carbon Nanotube‐Guided RNA Delivery to Improve Shoot Regeneration Efficiency in Plant Calli

Advanced Functional Materials, EarlyView.
The pH‐sensitive His6‐SWNTs, which is functionalized with oligohistidine, can deliver STTM396 molecules into callus cells. The STTM396–SWNT complex treatments enhance shoot regeneration efficiency by regulating the miR396‐GRF module in Arabidopsis and tomato calli.
Yeong Yeop Jeong, Hyuna Kwak, Woojin Jeong, Hongwoo Lee, Su‐Ji Jeon, Hyo‐Jun Lee, Pil Joon Seo, Seon‐Yeong Kwak   +7 more
wiley   +1 more source

Highly Customizable Scaffold‐Type 3D Microelectrode Array Platform for Design and Analysis of the 3D Neuronal Network In Vitro

Advanced Functional Materials, EarlyView.
An innovative fabrication platform for 3D microelectrode arrays (MEAs) is presented, utilizing a 3D printer and the capillary action of electrically conductive inks. This approach enables the simple and versatile fabrication of 3D MEAs with complex structures.
Dongjo Yoon, Yoonkey Nam
wiley   +1 more source

Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke

Chinese Medicine
Background Prognosis is critically important in stroke cases, with angiogenesis playing a key role in determining outcomes. This study aimed to investigate the potential protective effects of Atractylenolide I (Atr I), Atractylenolide III (Atr III), and ...
Haiyan Li, Wantong Yu, Yong Yang, Sijie Li, Jun Xu, Chen Gao, Wei Zhang, Wenjie Shi, Kunlin Jin, Xunming Ji, Changhong Ren   +10 more
doaj   +1 more source

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia [PDF]

, 2019
Paul C. McDonald, Shawn C. Chafe, Wells S. Brown, Saeed Saberi, Mridula Swayampakula, Geetha Venkateswaran, Oksana Nemirovsky, Jordan Gillespie, Joanna M. Karasinska, Steve E. Kalloger, Claudiu T. Supuran, David F. Schaeffer, Ali Bashashati, Sohrab P. Shah, James T. Topham, Donald T. Yapp, Jinyang Li, Daniel J. Renouf, Ben Z. Stanger, Shoukat Dedhar   +19 more
openalex   +1 more source

Biosupercapacitors for Human‐Powered Electronics

Advanced Functional Materials, EarlyView.
Biosupercapacitors are emerging as biocompatible and integrative energy systems for next‐generation bioelectronics, offering rapid charge–discharge performance and mechanical adaptability. This review systematically categorizes their applications from external to organ‐level systems and highlights their multifunctional roles in sensing, actuation, and ...
Suhyeon Kim, Seungho Baek, Woojung Jung, Hayeon Bae, Junyoung Mun, Yong Ho Kim, Sunkook Kim, Jung Ho Kim   +7 more
wiley   +1 more source

Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF‐β Pathway Inhibition

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in the Fibrillin‐1 gene, which encodes the extracellular matrix protein fibrillin‐1.
Yuhao Chen, Yuankang Zhu, Xiaoli Ren, Lu Ding, Yubin Xu, Miqi Zhou, Runze Dong, Peifeng Jin, Xiufang Chen, Xiaofang Fan, Ming Li, Yongsheng Gong, Yongyu Wang   +12 more
doaj   +1 more source

Asymmetric Dimethylarginine at Sea Level Is a Predictive Marker of Hypoxic Pulmonary Arterial Hypertension at High Altitude

Frontiers in Physiology, 2019
Background: Prolonged exposure to altitude-associated chronic hypoxia (CH) may cause high-altitude pulmonary hypertension (HAPH). Chronic intermittent hypobaric hypoxia (CIH) occurs in individuals who commute between sea level and high altitude.
Patricia Siques, Patricia Siques, Julio Brito, Julio Brito, Edzard Schwedhelm, Eduardo Pena, Eduardo Pena, Fabiola León-Velarde, Fabiola León-Velarde, Juan José De La Cruz, Rainer H. Böger, Rainer H. Böger, Juliane Hannemann, Juliane Hannemann   +13 more
doaj   +1 more source